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Patient-reported he...
Patient-reported health-related quality of life from a randomized phase II trial comparing standard-dose with high-dose twice daily thoracic radiotherapy in limited stage small-cell lung cancer
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Killingberg, K. T. (author)
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Halvorsen, T. O. (author)
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Flotten, O. (author)
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Brustugun, O. T. (author)
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Langer, S. W. (author)
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- Nyman, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Hornslien, K. (author)
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Madebo, T. (author)
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Schytte, T. (author)
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Risum, S. (author)
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- Tsakonas, G. (author)
- Karolinska Institutet
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Engleson, J. (author)
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Gronberg, B. H. (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Lung Cancer. - : Elsevier BV. - 0169-5002 .- 1872-8332. ; 166, s. 49-57
- Related links:
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http://www.lungcance...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives: In a randomized phase II trial, twice daily (BID) thoracic radiotherapy (TRT) of 60 Gy/40 frac-tions improved survival compared with 45 Gy/30 fractions in limited stage small-cell lung cancer (LS SCLC). Notably, the higher dose did not cause more toxicity. Here we present health related quality of life (HRQoL) reported by the trial participants during the first 2 years.& nbsp;Materials and methods: 170 patients were randomized 1:1 to TRT of 45 Gy or 60 Gy concurrently with cisplatin/etoposide chemotherapy. The 150 patients who commenced TRT and completed a minimum of one HRQoL-questionnaire were included in the present study. Patients reported HRQoL on the European Organization for Research and Treatment of Cancer Core 30 and Lung Cancer 13 Quality of Life Questionnaires. Questionnaires were completed weeks 0, 4 (before TRT), 8 (end of TRT), 12 (response evaluation after chemoradiotherapy) and 16 (end of prophylactic cranial irradiation), then every 10 weeks year one, and every 3 months year two. Primary HRQoL endpoints were dysphagia and dyspnea. A difference in mean score of >= 10 was defined as clinically significant.& nbsp;Results: Maximum dysphagia was reported on week 8, with no significant difference between treatment arms (mean scores 45 Gy: 44.2, 60 Gy: 51.1). The 60 Gy arm had more dysphagia in the convalescence period, but dysphagia scores returned to baseline levels at week 16 in both arms. For dyspnea there were no significant changes, or differences between treatment arms, at any timepoint. There were no significant differences between treatment arms for any other HRQoL-scales.& nbsp;Conclusion: TRT of 60 Gy did not cause significantly higher maximum dysphagia, though patients on the 60 Gy arm reported more dysphagia the first 8 weeks of convalescence. The higher dose was well tolerated and is an attractive alternative to current TRT schedules in LS SCLC.& nbsp;
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- LS SCLC
- Patient reported outcomes
- Health related quality of life
- Hyper fractionated
- Chemoradiotherapy
- Twice daily thoracic radiotherapy
- prophylactic cranial irradiation
- radiation
- chemotherapy
- chemoradiotherapy
- cisplatin
- outcomes
- qlq-c30
- patient
- burden
- scores
- Oncology
- Respiratory System
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Killingberg, K. ...
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Halvorsen, T. O.
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Flotten, O.
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Brustugun, O. T.
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Langer, S. W.
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Nyman, Jan, 1956
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show more...
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Hornslien, K.
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Madebo, T.
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Schytte, T.
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Risum, S.
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Tsakonas, G.
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Engleson, J.
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Gronberg, B. H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Lung Cancer
- By the university
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University of Gothenburg
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Karolinska Institutet