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Combining biomarker...
Combining biomarkers for prognostic modelling of Parkinson's disease
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Vijiaratnam, N. (author)
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Lawton, M. (author)
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Heslegrave, A. J. (author)
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Guo, T. (author)
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Tan, M. (author)
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Jabbari, E. (author)
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Real, R. (author)
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Woodside, J. (author)
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Grosset, K. (author)
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Chelban, V. (author)
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Athauda, D. (author)
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Girges, C. (author)
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Barker, R. A. (author)
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Hardy, J. (author)
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Wood, N. (author)
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Houlden, H. (author)
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Williams, N. (author)
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Ben-Shlomo, Y. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Grosset, D. G. (author)
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Foltynie, T. (author)
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Morris, H. R. (author)
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P. RoBaND Clinical Consortium, P. RoBaND Clinical Consortium (author)
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(creator_code:org_t)
- 2022-05-16
- 2022
- English.
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In: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 93:7, s. 707-715
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background Patients with Parkinson's disease (PD) have variable rates of progression. More accurate prediction of progression could improve selection for clinical trials. Although some variance in clinical progression can be predicted by age at onset and phenotype, we hypothesise that this can be further improved by blood biomarkers. Objective To determine if blood biomarkers (serum neurofilament light (NfL) and genetic status (glucocerebrosidase, GBA and apolipoprotein E (APOE))) are useful in addition to clinical measures for prognostic modelling in PD. Methods We evaluated the relationship between serum NfL and baseline and longitudinal clinical measures as well as patients' genetic (GBA and APOE) status. We classified patients as having a favourable or an unfavourable outcome based on a previously validated model, and explored how blood biomarkers compared with clinical variables in distinguishing prognostic phenotypes . Results 291 patients were assessed in this study. Baseline serum NfL was associated with baseline cognitive status. Nfl predicted a shorter time to dementia, postural instability and death (dementia-HR 2.64; postural instability-HR 1.32; mortality-HR 1.89) whereas APOEe4 status was associated with progression to dementia (dementia-HR 3.12, 95% CI 1.63 to 6.00). NfL levels and genetic variables predicted unfavourable progression to a similar extent as clinical predictors. The combination of clinical, NfL and genetic data produced a stronger prediction of unfavourable outcomes compared with age and gender (area under the curve: 0.74-age/gender vs 0.84-ALL p=0.0103). Conclusions Clinical trials of disease-modifying therapies might usefully stratify patients using clinical, genetic and NfL status at the time of recruitment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- parkinson's disease
- neurofilament light
- progression
- association
- diagnosis
- survival
- decline
- cohort
- blood
- motor
- nfl
- Neurosciences & Neurology
- Psychiatry
- Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vijiaratnam, N.
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Lawton, M.
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Heslegrave, A. J ...
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Guo, T.
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Tan, M.
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Jabbari, E.
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show more...
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Real, R.
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Woodside, J.
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Grosset, K.
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Chelban, V.
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Athauda, D.
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Girges, C.
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Barker, R. A.
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Hardy, J.
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Wood, N.
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Houlden, H.
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Williams, N.
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Ben-Shlomo, Y.
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Zetterberg, Henr ...
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Grosset, D. G.
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Foltynie, T.
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Morris, H. R.
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P. RoBaND Clinic ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg