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Longitudinal Serum ...
Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
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- Nilsson, Anders K., 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sect Ophthalmol, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.,Sahlgrenska Academy
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- Abdellah, Tebani (författare)
- KTH Royal Institute of Technology,KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Normandie Univ, Dept Metab Biochem, UNIROUEN, INSERM U1245,Rouen Univ Hosp, Rouen, France.,Rouen University Hospital
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- Malmodin, Daniel, 1974 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Svenskt NMR-centrum vid Göteborgs universitet,Swedish NMR Centre at Göteborg University,Univ Gothenburg, Swedish NMR Ctr, Gothenburg, Sweden.
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- Pedersen, Anders, 1976 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Svenskt NMR-centrum vid Göteborgs universitet,Swedish NMR Centre at Göteborg University,Univ Gothenburg, Swedish NMR Ctr, Gothenburg, Sweden.
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- Hellgren, Gunnel, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Svenskt NMR-centrum vid Göteborgs universitet,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Swedish NMR Centre at Göteborg University,Univ Gothenburg, Sect Ophthalmol, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Gothenburg, Sweden.,Sahlgrenska Academy
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- Löfqvist, Chatarina, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institutionen för biomedicin,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Institute of Biomedicine,Univ Gothenburg, Sect Ophthalmol, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Gothenburg, Inst Hlth & Care Sci, Sahlgrenska Acad, Gothenburg, Sweden.,Sahlgrenska Academy
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- Hansen-Pupp, Ingrid (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Skåne University Hospital
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- Uhlén, Mathias (författare)
- KTH Royal Institute of Technology,KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Hellström, Ann, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Sect Ophthalmol, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.,Sahlgrenska Academy
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(creator_code:org_t)
- 2022-02-17
- 2022
- Engelska.
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Ingår i: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-453X .- 1662-4548. ; 16
- Relaterad länk:
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https://www.frontier...
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https://doi.org/10.3...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- An increasing number of extremely premature infants survive the neonatal period and beyond. Little is known about the maturation of the preterm infant's metabolome and its relation to the development of morbidities. Using 1H-NMR, we investigated the serum metabolic profile of 87 infants born at a gestational age (GA) <28 weeks [mean GA (SD) 25.4 (1.4) weeks] in samples longitudinally collected from birth to term equivalent age. The infant metabolome was analyzed in relation to GA, postnatal age, nutrition, and preterm morbidities. At postnatal day 1, low GA correlated with high levels of 3-hydroxyisobutyrate, acetate, acetoacetate, acetone, formate, glucose, and valine. Nearly all quantified metabolites displayed postnatal concentration changes. For example, the two phospholipid-related metabolites myo-inositol and ethanolamine displayed a similar decline from birth over the first weeks of life, irrespectively of GA. The proportion of enteral/parenteral energy intake in the first 28 days significantly correlated with mean levels of 52% of the analyzed metabolites. Low enteral energy intake was associated with high serum levels of 3-hydroxyisobutyrate, creatinine, glucose, glycerol, histidine, lactate, leucine, lysine, methionine, ornithine, phenylalanine, proline, threonine, and uridine. There were also significant correlations between high enteral intake and high serum levels of isoleucine and tyrosine. Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) outcomes were not significantly associated with metabolite levels in the neonatal period after correcting for multiple testing. In conclusion, the serum metabolome of extremely premature infants changes substantially in the neonatal period, largely driven by the gradual transfer from total parenteral nutrition to full enteral feeding. Further studies are needed to disentangle the intricate relationships between the metabolome, nutritional management, GA, and the development of preterm morbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- bronchopulmonary dysplasia
- enteral nutrition
- parenteral nutrition
- retinopathy of prematurity
- ketone bodies
- ethanolamine
- one-carbon
- metabolism
- human milk
- extremely preterm infants
- hepatocyte proliferation
- retinopathy
- plasma
- supplementation
- ethanolamine
- association
- metabolites
- profiles
- outcomes
- Neurosciences & Neurology
- bronchopulmonary dysplasia
- one-carbon metabolism
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Nilsson, Anders ...
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Abdellah, Tebani
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Malmodin, Daniel ...
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Pedersen, Anders ...
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Hellgren, Gunnel ...
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Löfqvist, Chatar ...
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Hansen-Pupp, Ing ...
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Uhlén, Mathias
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Hellström, Ann, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Frontiers in Neu ...
- Av lärosätet
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Göteborgs universitet
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Kungliga Tekniska Högskolan
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Lunds universitet