A Computational Framework to Predict Calvarial Growth: Optimising Management of Sagittal Craniosynostosis

• The neonate skull consists of several bony plates, connected by fibrous soft tissue called sutures. Premature fusion of sutures is a medical condition known as craniosynostosis. Sagittal synostosis, caused by premature fusion of the sagittal suture, is the most common form of this condition. The optimum management of this condition is an ongoing debate in the craniofacial community while aspects of the biomechanics and mechanobiology are not well understood. Here, we describe a computational framework that enables us to predict and compare the calvarial growth following different reconstruction techniques for the management of sagittal synostosis. Our results demonstrate how different reconstruction techniques interact with the increasing intracranial volume. The framework proposed here can be used to inform optimum management of different forms of craniosynostosis, minimising the risk of functional consequences and secondary surgery.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)

Nyckelord

calvarial bones

sutures

skull growth

sagittal synostosis

finite

element method

biomechanics

intracranial volume

strip craniectomy

infant skull

suture

cranioplasty

synostosis

brain

Biotechnology & Applied Microbiology

Science & Technology - Other

Topics

Publikations- och innehållstyp

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