Sökning: WFRF:(Apple F. S.)
> (2020-2023) >
Analytical Consider...
Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers
-
Aakre, K. M. (författare)
-
Saenger, A. K. (författare)
-
Body, R. (författare)
-
visa fler...
-
Collinson, P. (författare)
-
- Hammarsten, Ola (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
-
Jaffe, A. S. (författare)
-
Kavsak, P. (författare)
-
Omland, T. (författare)
-
Ordonez-Lianos, J. (författare)
-
Apple, F. S. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2022-06-18
- 2022
- Engelska.
-
Ingår i: Clinical chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 68:8, s. 1022-1030
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac biomarkers in clinical laboratories and practice. The committee's goals are to improve the understanding of certain key analytical and clinical aspects of cardiac biomarkers and how these may interplay in clinical practice. Measurement of high-sensitivity cardiac troponin (hs-cTn) assays is a cornerstone in the clinical evaluation of patients with symptoms and/or signs of acute cardiac ischemia. To define myocardial infarction, the Universal Definition of Myocardial Infarction requires patients who manifest with features suggestive of acute myocardial ischemia to have at least one cTn concentration above the sex-specific 99th percentile upper reference limit (URL) for hs-cTn assays and a dynamic pattern of cTn concentrations to fulfill the diagnostic criteria for MI. This special report provides an overview of how hs-cTn 99th percentile URLs should be established, including recommendations about prescreening and the number of individuals required in the reference cohort, how statistical analysis should be conducted, optimal preanalytical and analytical protocols, and analytical/biological interferences or confounds that can affect accurate determination of the 99th percentile URLs. This document also provides guidance and solutions to many of the issues posed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- cardiac troponin
- high-sensitivity cardiac troponin
- 99th percentile
- chest pain
- diagnosis
- myocardial infarction
- myocardial injury
- prognosis
- nonischemic cardiovascular disease
- normality
- reference
- interval
- population selection
- thresholds
- diagnosis
- algorithm
- Medical Laboratory Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Aakre, K. M.
-
Saenger, A. K.
-
Body, R.
-
Collinson, P.
-
Hammarsten, Ola
-
Jaffe, A. S.
-
visa fler...
-
Kavsak, P.
-
Omland, T.
-
Ordonez-Lianos, ...
-
Apple, F. S.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Biomedicinsk lab ...
- Artiklar i publikationen
-
Clinical chemist ...
- Av lärosätet
-
Göteborgs universitet