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Postoperative morbi...
Postoperative morbidity and health-related quality of life in children with delayed reconstruction of esophageal atresia: a nationwide Swedish study
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- Dellenmark-Blom, Michaela, 1983 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Univ, Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, S-41685 Gothenburg, Sweden.,Queen Silvia Children’s Hospital
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- Örnö Ax, Sofie (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Univ, Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, S-41685 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Pediat Surg, Gothenburg, Sweden.,Queen Silvia Children’s Hospital
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- Ost, E. (författare)
- Karolinska Institute,Karolinska University Hospital
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- Svensson, J. F. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Univ Hosp, Dept Pediat Surg, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.,Karolinska University Hospital
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- Kassa, Ann-Marie, 1955- (författare)
- Uppsala University,Uppsala universitet,Barnkirurgisk forskning
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- Jönsson, Linus, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Univ, Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, S-41685 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Pediat Surg, Gothenburg, Sweden.,Queen Silvia Children’s Hospital
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- Abrahamsson, Kate, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Univ, Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, S-41685 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Pediat Surg, Gothenburg, Sweden.,Queen Silvia Children’s Hospital
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- Gatzinsky, Vladimir, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Gothenburg Univ, Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, S-41685 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Pediat Surg, Gothenburg, Sweden.,Queen Silvia Children’s Hospital
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- Stenström, Pernilla (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkirurgi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric surgery,Lund University Research Groups,Skåne University Hospital
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- Tollne, A. (författare)
- Karolinska Univ Hosp, Dept Pediat Surg, Stockholm, Sweden.,Karolinska University Hospital
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- Omling, Erik (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,Barnkirurgi,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Surgery and public health,Lund University Research Groups,Pediatric surgery,Skåne University Hospital
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- Engstrand Lilja, Helene, 1963- (författare)
- Uppsala University,Uppsala universitet,Karolinska Institutet,Barnkirurgisk forskning
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(creator_code:org_t)
- 2022-06-20
- 2022
- Engelska.
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Ingår i: Orphanet Journal of Rare Diseases. - : Springer Science and Business Media LLC. - 1750-1172. ; 17:1
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background In 10-15% of children with esophageal atresia (EA) delayed reconstruction of esophageal atresia (DREA) is necessary due to long-gap EA and/or prematurity/low birth weight. They represent a patient subgroup with high risk of complications. We aimed to evaluate postoperative morbidity and health-related quality of life (HRQOL) in a Swedish national cohort of children with DREA. Methods Postoperative morbidity, age-specific generic HRQOL (PedsQL((TM)) 4.0) and condition-specific HRQOL (The EA-QOL questionnaires) in children with DREA were compared with children with EA who had primary anastomosis (PA). Factors associated with the DREA group's HRQOL scores were analyzed using Mann-Whitney U-test and Spearman's rho. Clinical data was extracted from the medical records. Significance level was p < 0.05. Results Thirty-four out of 45 families of children with DREA were included and 30 returned the questionnaires(n = 8 children aged 2-7 years; n = 22 children aged 8-18 years). Compared to children with PA(42 children aged 2-7 years; 64 children aged 8-18 years), there were no significant differences in most early postoperative complications. At follow-up, symptom prevalence in children aged 2-7 with DREA ranged from 37.5% (heartburn) to 75% (cough). Further digestive and respiratory symptoms were present in >= 50%. In children aged 8-18, it ranged from 14.3% (vomiting) to 40.9% (cough), with other digestive and airway symptoms present in 19.0-27.3%. Except for chest tightness (2-7 years), there were no significant differences in symptom prevalence between children with DREA and PA, nor between their generic or condition-specific HRQOL scores (p > 0.05). More children with DREA underwent esophageal dilatations (both age groups), gastrostomy feeding (2-7 years), and antireflux treatment (8-18 years), p < 0.05. Days to hospital discharge after EA repair and a number of associated anomalies showed a strong negative correlation with HRQOL scores (2-7 years). Presence of cough, airway infection, swallowing difficulties and heartburn were associated with lower HRQOL scores (8-18 years), p < 0.05. Conclusions Although children with DREA need more treatments, they are not a risk group for postoperative morbidity and impaired HRQOL compared with children with PA. However, those with a long initial hospital stay, several associated anomalies and digestive or respiratory symptoms risk worse HRQOL. This is important information for clinical practice, families and patient stakeholders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Esophageal atresia
- Long-gap esophageal atresia
- Health-related quality
- of life
- Delayed reconstruction
- Long-term morbidity
- Postoperative
- outcomes
- birth-weight infants
- primary repair
- atresia/tracheoesophageal fistula
- adolescents born
- risk-factors
- gap
- replacement
- elongation
- experience
- anomalies
- Genetics & Heredity
- Research & Experimental Medicine
- Esophageal atresia
- Health-related quality of life
- Postoperative outcomes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Dellenmark-Blom, ...
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Örnö Ax, Sofie
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Ost, E.
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Svensson, J. F.
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Kassa, Ann-Marie ...
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Jönsson, Linus, ...
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visa fler...
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Abrahamsson, Kat ...
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Gatzinsky, Vladi ...
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Stenström, Perni ...
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Tollne, A.
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Omling, Erik
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Engstrand Lilja, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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Orphanet Journal ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Uppsala universitet
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Lunds universitet