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Real World Evaluati...
Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study
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- Kjallquist, U. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Acs, B. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Margolin, S. (författare)
- Karolinska Institutet,Stockholm South General Hospital
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- Karlsson, E. (författare)
- Karolinska Institute
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- Kessler, L. E. (författare)
- Karolinska Institute,Capio St. Görans Sjukhus
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- Hernandez, S. G. (författare)
- Capio St Gorans Hosp, Breast Ctr, S-11235 Stockholm, Sweden.,Capio St. Görans Sjukhus
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- Ekholm, Maria (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för laboratoriemedicin,Sahlgrenska Center for Cancer Research (SCCR),Department of Laboratory Medicine,Dept Oncol, S-55185 Jönköping, Jönköping Count, Sweden.;Univ Gothenburg, Sahlgrenska Ctr Canc Res, Inst Biomed, Dept Lab Med,Sahlgrenska Acad, S-41345 Gothenburg, Sweden.,Region Jönköping County,Sahlgrenska Academy
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- Lundgren, Christine (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Department of Clinical Sciences, Lund,Region Jönköping County
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- Olsson, E. (författare)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Lindman, Henrik (författare)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi
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- Foukakis, T. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Matikas, A. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Hartman, J. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- 2022-05-25
- 2022
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:11
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Gene expression signatures can provide important information on the risk of recurrence in patients with hormone receptor positive early breast cancer, and they can guide post-operative treatment. We have investigated how the implementation of gene-expression-based risk signatures with the Prosigna((R)) test impacted patient management in Sweden. The two major conclusions of this study are that prognostic factors derived from routine pathology were poor predictors of the intrinsic subtype and the risk of recurrence score, and that gene-expression-based risk combined with clinicopathological biomarkers (tumor size, Ki67, tumor grade) spared patients from adjuvant chemotherapy, but also identified patients who would potentially benefit from this treatment. Molecular signatures to guide decisions for adjuvant chemotherapy are recommended in early ER-positive, HER2-negative breast cancer. The objective of this study was to assess what impact gene-expression-based risk testing has had following its recommendation by Swedish national guidelines. Postmenopausal women with ER-positive, HER2-negative and node negative breast cancer at intermediate clinical risk and eligible for chemotherapy were identified retrospectively from five Swedish hospitals. Tumor characteristics, results from Prosigna((R)) test and final treatment decision were available for all patients. Treatment recommendations were compared with the last version of regional guidelines before the introduction of routine risk signature testing. Among the 360 included patients, 41% (n = 148) had a change in decision for adjuvant treatment based on Prosigna((R)) test result. Out of the patients with clinical indication for adjuvant chemotherapy, 52% (n = 118) could avoid treatment based on results from Prosigna((R)) test. On the contrary, 23% (n = 30) of the patients with no indication were escalated to receive adjuvant chemotherapy after testing. Ki67 could not distinguish between the Prosigna((R)) risk groups or intrinsic subtypes and did not significantly differ between patients in which decision for adjuvant therapy was changed based on the test results. In conclusion, we report the first real-world data from implementation of gene-expression-based risk assessment in a Swedish context, which may facilitate the optimization of future versions of the national guidelines.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- adjuvant chemotherapy
- breast cancer
- gene expression signature
- gene
- expression profiling
- impact
- Prosigna
- PAM50
- cancer american society
- positive breast-cancer
- distant recurrence
- pam50 risk
- molecular portraits
- oncotype dx
- women
- trial
- score
- decisions
- Oncology
- adjuvant chemotherapy
- gene expression profiling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancers
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Till lärosätets databas
- Av författaren/redakt...
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Kjallquist, U.
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Acs, B.
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Margolin, S.
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Karlsson, E.
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Kessler, L. E.
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Hernandez, S. G.
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Ekholm, Maria
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Lundgren, Christ ...
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Olsson, E.
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Lindman, Henrik
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Foukakis, T.
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Matikas, A.
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Hartman, J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet