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Standardisation of ...
Standardisation of ACPA tests: evaluation of a new candidate reference preparation
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- Van Hoovels, L. (author)
- Katholieke Univ Leuven, Belgium; Onze Lieve Vrouwziekenhuis Aalst, Belgium
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- Studholme, L. (author)
- Natl Inst Biol Stand & Controls, England
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- Vander Cruyssen, B. (author)
- Onze Lieve Vrouwziekenhuis Aalst, Belgium
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- Sieghart, D. (author)
- Med Univ Vienna, Austria
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- Bonroy, C. (author)
- Univ Ghent, Belgium; Univ Ghent, Belgium
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- Nagy, E. (author)
- Natl Inst Locomotor Dis & Disabil, Hungary
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- Pullerits, Rille, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Cucnik, S. (author)
- Univ Med Ctr Ljubljana, Slovenia
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- Dahle, Charlotte (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Heijnen, I. (author)
- Univ Hosp Basel, Switzerland
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- Bernasconi, L. (author)
- Kantonsspital Aarau, Switzerland
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- Benkhadra, F. (author)
- Ctr Hosp Luxembourg, Luxembourg
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- Bogaert, L. (author)
- Onze Lieve Vrouwziekenhuis Aalst, Belgium
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- Van den Bremt, S. (author)
- Onze Lieve Vrouwziekenhuis Aalst, Belgium
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- Van Liedekerke, A. (author)
- AZ Sint Elisabeth Ziekenhuis Zottegem Vzw, Belgium
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- Vanheule, G. (author)
- AZ Rivierenland, Belgium
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- Robbrecht, J. (author)
- AZ Sint Lucas Bruges, Belgium
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- Wirth, C. (author)
- Ctr Hosp Luxembourg, Luxembourg
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- Muller, R. (author)
- Rheumazentrum Ostschweiz, Switzerland
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- Kyburz, D. (author)
- Univ Hosp Basel, Switzerland
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- Sjöwall, Christopher (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Jese, R. (author)
- Univ Med Ctr Ljubljana, Slovenia
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- Jovancevic, Boja (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sweden
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- Kiss, E. (author)
- Natl Inst Locomotor Dis & Disabil, Hungary
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- Jacques, P. (author)
- Univ Hosp Ghent, Belgium; Univ Hosp Ghent, Belgium
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- Aletaha, D. (author)
- Med Univ Vienna, Austria
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- Steiner, G. (author)
- Med Univ Vienna, Austria; Ludwig Boltzmann Inst Arthrit & Rehabil, Austria
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- Verschueren, P. (author)
- Univ Hosp Leuven, Belgium; Univ Hosp Leuven, Belgium
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- Bossuyt, X. (author)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium
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(creator_code:org_t)
- 2022-06-13
- 2022
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 81:10, s. 1379-1384
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction Commercial assays measuring antibodies to citrullinated protein/peptide (ACPA) show poor quantitative agreement. The diagnostic industry has never adopted the International Union of Immunological Societies-Centers for Disease Control and Prevention (IUIS-CDC) ACPA reference standard. Recently, the National Institute for Biological Standards and Control (NIBSC) prepared a new candidate ACPA standard (18/204). We evaluated both reference materials using different commercially available ACPA assays. Materials and methods This is an international study in which the NIBSC candidate ACPA standard and the IUIS-CDC ACPA reference material were analysed together with 398 diagnostic samples from individuals with rheumatoid arthritis (RA) and in 1073 individuals who did not have RA using nine commercial ACPA assays. Results For both reference materials and samples from individuals with RA and individuals who did not have RA, there were large differences in quantitative ACPA results between assays. For most assays, values for the IUIS-CDC standard were lower than values for NIBSC 18/204 and the IUIS-CDC/NIBSC ratio was comparable for several, but not all assays. When NIBSC 18/204 was used as a calibrator, an improvement in alignment of ACPA results across several of the evaluated assays was obtained. Moreover, NIBSC 18/204 could align clinical interpretation for some but not all assays. Conclusion Adoption of an international standard for ACPA determination is highly desirable. The candidate NIBSC 18/204 standard improved the standardisation and alignment of most ACPA assays and might therefore be recommended to be used as reference in commercial assays.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- anti-citrullinated protein antibody
- reference material
- NIBSC
- standardization
- classification
- performance
- antibodies
- assays
- Rheumatology
- anti-citrullinated protein antibody; reference material; NIBSC; standardization
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Van Hoovels, L.
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Studholme, L.
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Vander Cruyssen, ...
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Sieghart, D.
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Bonroy, C.
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Nagy, E.
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show more...
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Pullerits, Rille ...
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Cucnik, S.
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Dahle, Charlotte
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Heijnen, I.
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Bernasconi, L.
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Benkhadra, F.
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Bogaert, L.
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Van den Bremt, S ...
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Van Liedekerke, ...
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Vanheule, G.
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Robbrecht, J.
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Wirth, C.
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Muller, R.
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Kyburz, D.
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Sjöwall, Christo ...
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Kastbom, Alf
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Jese, R.
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Jovancevic, Boja
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Kiss, E.
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Jacques, P.
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Aletaha, D.
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Steiner, G.
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Verschueren, P.
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Bossuyt, X.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Annals of the Rh ...
- By the university
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University of Gothenburg
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Linköping University