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The risk of COVID-1...
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
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Manry, Jérémy (author)
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Bastard, Paul (author)
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Gervais, Adrian (author)
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show more...
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Le Voyer, Tom (author)
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Rosain, Jérémie (author)
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Philippot, Quentin (author)
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Michailidis, Eleftherios (author)
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Hoffmann, Hans-Heinrich (author)
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Eto, Shohei (author)
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Garcia-Prat, Marina (author)
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Bizien, Lucy (author)
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Parra-Martínez, Alba (author)
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Yang, Rui (author)
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Haljasmägi, Liis (author)
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Migaud, Mélanie (author)
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Särekannu, Karita (author)
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Maslovskaja, Julia (author)
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de Prost, Nicolas (author)
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Tandjaoui-Lambiotte, Yacine (author)
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Luyt, Charles-Edouard (author)
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Amador-Borrero, Blanca (author)
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Gaudet, Alexandre (author)
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Poissy, Julien (author)
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Morel, Pascal (author)
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Richard, Pascale (author)
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Cognasse, Fabrice (author)
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Troya, Jesús (author)
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Trouillet-Assant, Sophie (author)
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Belot, Alexandre (author)
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Saker, Kahina (author)
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Garçon, Pierre (author)
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Rivière, Jacques G (author)
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Lagier, Jean-Christophe (author)
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Gentile, Stéphanie (author)
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Rosen, Lindsey B (author)
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Shaw, Elana (author)
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Morio, Tomohiro (author)
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Tanaka, Junko (author)
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Dalmau, David (author)
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Tharaux, Pierre-Louis (author)
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Sene, Damien (author)
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Stepanian, Alain (author)
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Mégarbane, Bruno (author)
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Triantafyllia, Vasiliki (author)
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Fekkar, Arnaud (author)
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Heath, James R (author)
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Franco, José Luis (author)
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Anaya, Juan-Manuel (author)
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Solé-Violán, Jordi (author)
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Imberti, Luisa (author)
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Biondi, Andrea (author)
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Bonfanti, Paolo (author)
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Castagnoli, Riccardo (author)
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Delmonte, Ottavia M (author)
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Zhang, Yu (author)
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Snow, Andrew L (author)
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Holland, Steven M (author)
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Biggs, Catherine M (author)
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Moncada-Vélez, Marcela (author)
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Arias, Andrés Augusto (author)
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- Lorenzo, Lazaro (author)
- Karolinska Institutet
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Boucherit, Soraya (author)
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Anglicheau, Dany (author)
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Planas, Anna M (author)
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Haerynck, Filomeen (author)
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Duvlis, Sotirija (author)
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Ozcelik, Tayfun (author)
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Keles, Sevgi (author)
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Bousfiha, Ahmed A (author)
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El Bakkouri, Jalila (author)
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Ramirez-Santana, Carolina (author)
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Paul, Stéphane (author)
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- Pan-Hammarström, Qiang (author)
- Karolinska Institutet
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Hammarström, Lennart (author)
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Dupont, Annabelle (author)
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Kurolap, Alina (author)
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Metz, Christine N (author)
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Aiuti, Alessandro (author)
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Casari, Giorgio (author)
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Lampasona, Vito (author)
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Ciceri, Fabio (author)
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Barreiros, Lucila A (author)
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Dominguez-Garrido, Elena (author)
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Vidigal, Mateus (author)
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Zatz, Mayana (author)
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van de Beek, Diederik (author)
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Sahanic, Sabina (author)
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Tancevski, Ivan (author)
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Stepanovskyy, Yurii (author)
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Boyarchuk, Oksana (author)
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Nukui, Yoko (author)
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Tsumura, Miyuki (author)
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Vidaur, Loreto (author)
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Tangye, Stuart G (author)
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Burrel, Sonia (author)
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Duffy, Darragh (author)
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Quintana-Murci, Lluis (author)
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Klocperk, Adam (author)
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Kann, Nelli Y (author)
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Shcherbina, Anna (author)
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Lau, Yu-Lung (author)
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Leung, Daniel (author)
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Coulongeat, Matthieu (author)
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Marlet, Julien (author)
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Koning, Rutger (author)
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Reyes, Luis Felipe (author)
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Chauvineau-Grenier, Angélique (author)
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Venet, Fabienne (author)
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Monneret, Guillaume (author)
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Nussenzweig, Michel C (author)
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Arrestier, Romain (author)
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Boudhabhay, Idris (author)
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Baris-Feldman, Hagit (author)
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Hagin, David (author)
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Wauters, Joost (author)
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Meyts, Isabelle (author)
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Dyer, Adam H (author)
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Kennelly, Sean P (author)
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Bourke, Nollaig M (author)
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Halwani, Rabih (author)
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Sharif-Askari, Fatemeh Saheb (author)
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Dorgham, Karim (author)
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Sallette, Jérôme (author)
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Sedkaoui, Souad Mehlal (author)
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AlKhater, Suzan (author)
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Rigo-Bonnin, Raúl (author)
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Morandeira, Francisco (author)
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Roussel, Lucie (author)
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Vinh, Donald C (author)
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Erikstrup, Christian (author)
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Condino-Neto, Antonio (author)
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Prando, Carolina (author)
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Bondarenko, Anastasiia (author)
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Spaan, András N (author)
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Gilardin, Laurent (author)
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Fellay, Jacques (author)
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Lyonnet, Stanislas (author)
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Bilguvar, Kaya (author)
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Lifton, Richard P (author)
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Mane, Shrikant (author)
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Clinical Sciences, Department of Pediatrics
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Anderson, Mark S (author)
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Boisson, Bertrand (author)
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Béziat, Vivien (author)
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Zhang, Shen-Ying (author)
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Andreakos, Evangelos (author)
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Hermine, Olivier (author)
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Pujol, Aurora (author)
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Peterson, Pärt (author)
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Mogensen, Trine H (author)
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Rowen, Lee (author)
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Mond, James (author)
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Debette, Stéphanie (author)
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de Lamballerie, Xavier (author)
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Burdet, Charles (author)
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Bouadma, Lila (author)
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Zins, Marie (author)
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Soler-Palacin, Pere (author)
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Colobran, Roger (author)
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Gorochov, Guy (author)
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Solanich, Xavier (author)
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Susen, Sophie (author)
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Martinez-Picado, Javier (author)
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Raoult, Didier (author)
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Vasse, Marc (author)
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Gregersen, Peter K (author)
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Piemonti, Lorenzo (author)
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Rodríguez-Gallego, Carlos (author)
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Notarangelo, Luigi D (author)
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Su, Helen C (author)
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Kisand, Kai (author)
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Okada, Satoshi (author)
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Puel, Anne (author)
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Jouanguy, Emmanuelle (author)
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Rice, Charles M (author)
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Tiberghien, Pierre (author)
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Zhang, Qian (author)
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Casanova, Jean-Laurent (author)
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Abel, Laurent (author)
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Cobat, Aurélie (author)
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(creator_code:org_t)
- 2022-05-16
- 2022
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:21
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Adult
- Age Factors
- Aged
- Aged
- 80 and over
- Antibodies
- Neutralizing
- blood
- Autoantibodies
- blood
- Autoimmunity
- COVID-19
- immunology
- mortality
- Female
- Humans
- Interferon Type I
- immunology
- Male
- Middle Aged
- Risk
- SARS-CoV-2
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Manry, Jérémy
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Bastard, Paul
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Gervais, Adrian
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Le Voyer, Tom
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Rosain, Jérémie
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Philippot, Quent ...
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show more...
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Michailidis, Ele ...
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Hoffmann, Hans-H ...
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Eto, Shohei
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Garcia-Prat, Mar ...
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Bizien, Lucy
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Parra-Martínez, ...
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Yang, Rui
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Haljasmägi, Liis
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Migaud, Mélanie
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Särekannu, Karit ...
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Maslovskaja, Jul ...
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de Prost, Nicola ...
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Tandjaoui-Lambio ...
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Luyt, Charles-Ed ...
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Amador-Borrero, ...
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Gaudet, Alexandr ...
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Poissy, Julien
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Morel, Pascal
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Richard, Pascale
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Cognasse, Fabric ...
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Troya, Jesús
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Trouillet-Assant ...
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Belot, Alexandre
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Saker, Kahina
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Garçon, Pierre
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Rivière, Jacques ...
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Lagier, Jean-Chr ...
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Gentile, Stéphan ...
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Rosen, Lindsey B
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Shaw, Elana
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Morio, Tomohiro
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Tanaka, Junko
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Dalmau, David
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Tharaux, Pierre- ...
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Sene, Damien
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Stepanian, Alain
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Mégarbane, Bruno
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Triantafyllia, V ...
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Fekkar, Arnaud
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Heath, James R
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Franco, José Lui ...
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Anaya, Juan-Manu ...
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Solé-Violán, Jor ...
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Imberti, Luisa
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Biondi, Andrea
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Bonfanti, Paolo
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Castagnoli, Ricc ...
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Delmonte, Ottavi ...
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Zhang, Yu
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Snow, Andrew L
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Holland, Steven ...
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Biggs, Catherine ...
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Moncada-Vélez, M ...
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Arias, Andrés Au ...
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Lorenzo, Lazaro
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Boucherit, Soray ...
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Anglicheau, Dany
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Planas, Anna M
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Haerynck, Filome ...
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Duvlis, Sotirija
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Ozcelik, Tayfun
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Keles, Sevgi
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Bousfiha, Ahmed ...
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El Bakkouri, Jal ...
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Ramirez-Santana, ...
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Paul, Stéphane
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Pan-Hammarström, ...
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Hammarström, Len ...
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Dupont, Annabell ...
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Kurolap, Alina
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Metz, Christine ...
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Aiuti, Alessandr ...
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Casari, Giorgio
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Lampasona, Vito
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Ciceri, Fabio
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Barreiros, Lucil ...
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Dominguez-Garrid ...
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Vidigal, Mateus
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Zatz, Mayana
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van de Beek, Die ...
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Sahanic, Sabina
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Tancevski, Ivan
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Stepanovskyy, Yu ...
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Boyarchuk, Oksan ...
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Nukui, Yoko
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Tsumura, Miyuki
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Vidaur, Loreto
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Tangye, Stuart G
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Burrel, Sonia
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Duffy, Darragh
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Quintana-Murci, ...
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Klocperk, Adam
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Kann, Nelli Y
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Shcherbina, Anna
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Lau, Yu-Lung
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Leung, Daniel
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Coulongeat, Matt ...
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Marlet, Julien
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Koning, Rutger
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Reyes, Luis Feli ...
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Chauvineau-Greni ...
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Venet, Fabienne
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Monneret, Guilla ...
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Nussenzweig, Mic ...
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Arrestier, Romai ...
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Boudhabhay, Idri ...
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Baris-Feldman, H ...
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Hagin, David
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Wauters, Joost
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Meyts, Isabelle
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Dyer, Adam H
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Kennelly, Sean P
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Bourke, Nollaig ...
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Halwani, Rabih
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Sharif-Askari, F ...
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Dorgham, Karim
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Sallette, Jérôme
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Sedkaoui, Souad ...
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AlKhater, Suzan
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Rigo-Bonnin, Raú ...
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Morandeira, Fran ...
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Roussel, Lucie
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Vinh, Donald C
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Erikstrup, Chris ...
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Condino-Neto, An ...
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Prando, Carolina
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Bondarenko, Anas ...
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Spaan, András N
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Gilardin, Lauren ...
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Fellay, Jacques
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Lyonnet, Stanisl ...
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Bilguvar, Kaya
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Lifton, Richard ...
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Mane, Shrikant
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Ekwall, Olov, 19 ...
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Anderson, Mark S
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Boisson, Bertran ...
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Béziat, Vivien
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Zhang, Shen-Ying
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Andreakos, Evang ...
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Hermine, Olivier
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Pujol, Aurora
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Peterson, Pärt
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Mogensen, Trine ...
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Rowen, Lee
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Mond, James
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Debette, Stéphan ...
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de Lamballerie, ...
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Burdet, Charles
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Bouadma, Lila
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Zins, Marie
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Soler-Palacin, P ...
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Colobran, Roger
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Gorochov, Guy
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Solanich, Xavier
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Susen, Sophie
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Martinez-Picado, ...
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Raoult, Didier
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Vasse, Marc
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Gregersen, Peter ...
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Piemonti, Lorenz ...
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Rodríguez-Galleg ...
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Notarangelo, Lui ...
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Su, Helen C
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Kisand, Kai
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Okada, Satoshi
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Puel, Anne
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Jouanguy, Emmanu ...
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Rice, Charles M
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Tiberghien, Pier ...
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Zhang, Qian
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Casanova, Jean-L ...
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Abel, Laurent
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Cobat, Aurélie
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Karolinska Institutet