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Reactive astroglios...
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
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Salvado, G. (författare)
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Mila-Aloma, M. (författare)
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Shekari, M. (författare)
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visa fler...
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- Ashton, Nicholas J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Operto, G. (författare)
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Falcon, C. (författare)
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Cacciaglia, R. (författare)
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Minguillon, C. (författare)
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Fauria, K. (författare)
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Ninerola-Baizan, A. (författare)
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Perissinotti, A. (författare)
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- Lessa Benedet, Andréa (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Kollmorgen, G. (författare)
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Suridjan, I. (författare)
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Wild, N. (författare)
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Molinuevo, J. L. (författare)
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Zetterberg, Henrik, 1973 (författare)
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Blennow, Kaj, 1958 (författare)
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Suarez-Calvet, M. (författare)
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Gispert, J. D. (författare)
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visa färre...
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(creator_code:org_t)
- 2022-07-18
- 2022
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 49, s. 4567-4579
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose Glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid (CSF) and blood. Plasma GFAP has been suggested to become altered earlier in AD than its CSF counterpart. Although astrocytes consume approximately half of the glucose-derived energy in the brain, the relationship between reactive astrogliosis and cerebral glucose metabolism is poorly understood. Here, we aimed to investigate the association between fluorodeoxyglucose ([F-18]FDG) uptake and reactive astrogliosis, by means of GFAP quantified in both plasma and CSF for the same participants. Methods We included 314 cognitively unimpaired participants from the ALFA + cohort, 112 of whom were amyloid-beta (A beta) positive. Associations between GFAP markers and [F-18]FDG uptake were studied. We also investigated whether these associations were modified by A beta and tau status (AT stages). Results Plasma GFAP was positively associated with glucose consumption in the whole brain, while CSF GFAP associations with [F-18]FDG uptake were only observed in specific smaller areas like temporal pole and superior temporal lobe. These associations persisted when accounting for biomarkers of A beta pathology but became negative in A beta-positive and tau-positive participants (A + T +) in similar areas of AD-related hypometabolism. Conclusions Higher astrocytic reactivity, probably in response to early AD pathological changes, is related to higher glucose consumption. With the onset of tau pathology, the observed uncoupling between astrocytic biomarkers and glucose consumption might be indicative of a failure to sustain the higher energetic demands required by reactive astrocytes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Glia
- Gliosis
- Astroglia
- Reactive astrocyte
- Glucose metabolism
- Glucose consumption
- energy-metabolism
- amyloid-pet
- brain
- astrocytes
- disease
- plasma
- neuroinflammation
- neurons
- protein
- signal
- Radiology
- Nuclear Medicine & Medical Imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Salvado, G.
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Mila-Aloma, M.
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Shekari, M.
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Ashton, Nicholas ...
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Operto, G.
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Falcon, C.
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visa fler...
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Cacciaglia, R.
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Minguillon, C.
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Fauria, K.
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Ninerola-Baizan, ...
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Perissinotti, A.
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Lessa Benedet, A ...
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Kollmorgen, G.
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Suridjan, I.
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Wild, N.
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Molinuevo, J. L.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Suarez-Calvet, M ...
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Gispert, J. D.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Göteborgs universitet