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Astrocyte biomarker...
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Ferrari-Souza, J. P.
(author)
Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's disease
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-08-10
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/318261
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https://gup.ub.gu.se/publication/318261URI
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https://doi.org/10.1038/s41380-022-01716-2DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer's disease (AD) patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like protein 1 (YKL-40) levels with brain amyloid-beta (A beta) and tau pathologies. We assessed 121 individuals across the aging and AD clinical spectrum with positron emission tomography (PET) brain imaging for A beta ([F-18]AZD4694) and tau ([F-18]MK-6240), as well as CSF GFAP and YKL-40 measures. We observed that higher CSF GFAP levels were associated with elevated A beta-PET but not tau-PET load. By contrast, higher CSF YKL-40 levels were associated with elevated tau-PET but not A beta-PET burden. Structural equation modeling revealed that CSF GFAP and YKL-40 mediate the effects of A beta and tau, respectively, on hippocampal atrophy, which was further associated with cognitive impairment. Our results suggest the existence of distinct astrocyte biomarker signatures in response to brain A beta and tau accumulation, which may contribute to our understanding of the complex link between reactive astrogliosis heterogeneity and AD progression.
Subject headings and genre
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Ferreira, P. C. L.
(author)
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Bellaver, B.
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Tissot, C.
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Wang, Y. T.
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Leffa, D. T.
(author)
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Brum, Wagner S.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
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Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan
(author)
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
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De Bastiani, M. A.
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Rocha, A.
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Therriault, J.
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Lussier, F. Z.
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Chamoun, M.
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Servaes, S.
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Bezgin, G.
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Kang, M. S.
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Stevenson, J.
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Rahmouni, N.
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Pallen, V.
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Poltronetti, N. M.
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Klunk, W. E.
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Tudorascu, D. L.
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Cohen, A. D.
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Villemagne, V. L.
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Gauthier, S.
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Souza, D. O.
(author)
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Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
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Zimmer, E. R.
(author)
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Rosa-Neto, P.
(author)
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Pascoal, T. A.
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Molecular Psychiatry: Springer Science and Business Media LLC27:11, s. 4781-47891359-41841476-5578
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Ferrari-Souza, J ...
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Ferreira, P. C. ...
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Bellaver, B.
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Tissot, C.
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Wang, Y. T.
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Leffa, D. T.
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Brum, Wagner S.
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Lessa Benedet, A ...
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Ashton, Nicholas ...
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De Bastiani, M. ...
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Rocha, A.
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Therriault, J.
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Lussier, F. Z.
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Chamoun, M.
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Servaes, S.
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Bezgin, G.
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Kang, M. S.
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Stevenson, J.
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Rahmouni, N.
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Pallen, V.
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Poltronetti, N. ...
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Klunk, W. E.
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Tudorascu, D. L.
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Cohen, A. D.
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Villemagne, V. L ...
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Gauthier, S.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Souza, D. O.
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Karikari, Thomas
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Zimmer, E. R.
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Rosa-Neto, P.
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Pascoal, T. A.
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- MEDICAL AND HEALTH SCIENCES
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and Neurology
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Molecular Psychi ...
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University of Gothenburg