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  • Ferrari-Souza, J. P. (author)

Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's disease

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08-10
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/318261
  • https://gup.ub.gu.se/publication/318261URI
  • https://doi.org/10.1038/s41380-022-01716-2DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer's disease (AD) patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like protein 1 (YKL-40) levels with brain amyloid-beta (A beta) and tau pathologies. We assessed 121 individuals across the aging and AD clinical spectrum with positron emission tomography (PET) brain imaging for A beta ([F-18]AZD4694) and tau ([F-18]MK-6240), as well as CSF GFAP and YKL-40 measures. We observed that higher CSF GFAP levels were associated with elevated A beta-PET but not tau-PET load. By contrast, higher CSF YKL-40 levels were associated with elevated tau-PET but not A beta-PET burden. Structural equation modeling revealed that CSF GFAP and YKL-40 mediate the effects of A beta and tau, respectively, on hippocampal atrophy, which was further associated with cognitive impairment. Our results suggest the existence of distinct astrocyte biomarker signatures in response to brain A beta and tau accumulation, which may contribute to our understanding of the complex link between reactive astrogliosis heterogeneity and AD progression.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ferreira, P. C. L. (author)
  • Bellaver, B. (author)
  • Tissot, C. (author)
  • Wang, Y. T. (author)
  • Leffa, D. T. (author)
  • Brum, Wagner S.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)
  • Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan (author)
  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (author)
  • De Bastiani, M. A. (author)
  • Rocha, A. (author)
  • Therriault, J. (author)
  • Lussier, F. Z. (author)
  • Chamoun, M. (author)
  • Servaes, S. (author)
  • Bezgin, G. (author)
  • Kang, M. S. (author)
  • Stevenson, J. (author)
  • Rahmouni, N. (author)
  • Pallen, V. (author)
  • Poltronetti, N. M. (author)
  • Klunk, W. E. (author)
  • Tudorascu, D. L. (author)
  • Cohen, A. D. (author)
  • Villemagne, V. L. (author)
  • Gauthier, S. (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Souza, D. O. (author)
  • Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit (author)
  • Zimmer, E. R. (author)
  • Rosa-Neto, P. (author)
  • Pascoal, T. A. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Molecular Psychiatry: Springer Science and Business Media LLC27:11, s. 4781-47891359-41841476-5578

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