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An accurate fully a...
An accurate fully automated panel of plasma biomarkers for Alzheimer's disease
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- Palmqvist, Sebastian (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Stomrud, Erik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Cullen, Nicholas (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Janelidze, Shorena (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Manuilova, E. (author)
- Roche Diagnostics, Germany
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- Jethwa, A. (author)
- Roche Diagnostics, Germany
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- Bittner, T. (author)
- F. Hoffmann-La Roche AG
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- Eichenlaub, U. (author)
- Roche Diagnostics, Germany
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Suridjan, I. (author)
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- Kollmorgen, G. (author)
- Roche Diagnostics, Germany
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- Riepe, M. (author)
- University of Ulm
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- von Arnim, C. A. F. (author)
- University Medical Center Göttingen
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- Tumani, H. (author)
- University Hospital of Ulm
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- Hager, K. (author)
- Hannover Medical School
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Heidenreich, F. (author)
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- Mattsson-Carlgren, Niklas (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,Sahlgrenska University Hospital,Hong Kong Center for Neurodegenerative Diseases,University College London
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2022-08-11
- 2023
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:4, s. 1204-1215
- Related links:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Introduction There is a great need for fully automated plasma assays that can measure amyloid beta (A beta) pathology and predict future Alzheimer's disease (AD) dementia. Methods Two cohorts (n = 920) were examined: Panel A+ (n = 32 cognitively unimpaired [CU], n = 106 mild cognitive impairment [MCI], and n = 89 AD) and BioFINDER-1 (n = 461 CU, n = 232 MCI). Plasma A beta 42/A beta 40, phosphorylated tau (p-tau)181, two p-tau217 variants, ApoE4 protein, neurofilament light, and GFAP were measured using Elecsys prototype immunoassays. Results The best biomarker for discriminating A beta-positive versus A beta-negative participants was A beta 42/A beta 40 (are under the curve [AUC] 0.83-0.87). Combining A beta 42/A beta 40, p-tau181, and ApoE4 improved the AUCs significantly (0.90 to 0.93; P< 0.01). Adding additional biomarkers had marginal effects (Delta AUC <= 0.01). In BioFINDER, p-tau181, p-tau217, and ApoE4 predicted AD dementia within 6 years in CU (AUC 0.88) and p-tau181, p-tau217, and A beta 42/A beta 40 in MCI (AUC 0.87). Discussion The high accuracies for A beta pathology and future AD dementia using fully automated instruments are promising for implementing plasma biomarkers in clinical trials and clinical routine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid beta
- apolipoprotein E
- area under the
- curve
- blood
- cerebrospinal fluid
- clinical practice
- cognitively
- unimpaired
- diagnostics
- Elecsys
- fully automated instruments
- glial
- fibrillary acidic protein
- immunoassays
- implementation
- mild cognitive
- impairment
- neurofilament light
- phosphorylated tau
- plasma
- prediction
- prognostics
- mild cognitive impairment
- phosphorylated tau 181
- clinical-diagnosis
- amyloid-beta
- cross-validation
- recommendations
- performance
- pathology
- Neurosciences & Neurology
- area under the curve
- cognitively unimpaired
- glial fibrillary acidic protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Palmqvist, Sebas ...
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Stomrud, Erik
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Cullen, Nicholas
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Janelidze, Shore ...
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Manuilova, E.
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Jethwa, A.
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show more...
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Bittner, T.
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Eichenlaub, U.
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Suridjan, I.
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Kollmorgen, G.
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Riepe, M.
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von Arnim, C. A. ...
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Tumani, H.
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Hager, K.
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Heidenreich, F.
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Mattsson-Carlgre ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Hansson, Oskar
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg
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Lund University