Sökning: onr:"swepub:oai:gup.ub.gu.se/318613" > Islet Gene View-a t...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 08674naa a2200733 4500 | |
001 | oai:gup.ub.gu.se/318613 | |
003 | SwePub | |
008 | 240910s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-483882 | |
009 | oai:lup.lub.lu.se:6578fb3c-e71f-4d4b-ae6e-4d28314eebe8 | |
024 | 7 | a https://gup.ub.gu.se/publication/3186132 URI |
024 | 7 | a https://doi.org/10.26508/lsa.2022013762 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4838822 URI |
024 | 7 | a https://lup.lub.lu.se/record/6578fb3c-e71f-4d4b-ae6e-4d28314eebe82 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Asplund, Olofu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-oap |
245 | 1 0 | a Islet Gene View-a tool to facilitate islet research |
264 | c 2022-08-10 | |
264 | 1 | b Life Science Alliance, LLC,c 2022 |
520 | a Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to create the Islet Gene View (IGW) platform to make this information easily accessible to the scientific community. Expression data were related to islet phenotypes, diabetes status, other islet-expressed genes, islet hormone-encoding genes and for expression in insulin target tissues. The IGW web application produces output graphs for a particular gene of interest. In IGW, 284 differentially expressed genes (DEGs) were identified in T2D donor islets compared with controls. Forty percent of DEGs showed cell-type enrichment and a large proportion significantly co-expressed with islet hormone-encoding genes; glucagon (GCG, 56%), amylin (IAPP, 52%), insulin (INS, 44%), and somatostatin (SST, 24%). Inhibition of two DEGs, UNC5D and SERPINE2, impaired glucose-stimulated insulin secretion and impacted cell survival in a human beta-cell model. The exploratory use of IGW could help designing more comprehensive functional follow-up studies and serve to identify therapeutic targets in T2D. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a genome-wide association | |
653 | a human pancreatic-islets | |
653 | a insulin-secretion | |
653 | a expression | |
653 | a transcription | |
653 | a variants | |
653 | a Life Sciences & Biomedicine - Other Topics | |
700 | 1 | a Storm, Petteru Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-psm |
700 | 1 | a Chandra, V.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Hatem, Gadu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)ga5503ha |
700 | 1 | a Ottosson-Laakso, Emiliau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-eo_ |
700 | 1 | a Mansour-Aly, Dinau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)di3053ma |
700 | 1 | a Krus, Ulrikau Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,CRC, Clinical Research Centre,Medicinska fakulteten,Lund University Bioimaging Center,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,CRC, Clinical Research Centre,Faculty of Medicine4 aut0 (Swepub:lu)medk-ufr |
700 | 1 | a Ibrahim, H.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki4 aut0 (Swepub:lu)ti8736tu |
700 | 1 | a Renström, Eriku Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ere |
700 | 1 | a Korsgren, Olleu Uppsala University,Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Institutionen för immunologi, genetik och patologi,, Sweden.;Univ Gothenburg, Inst Biomed, Dept Clin Chem & Transfus Med, Gothenburg, Sweden.4 aut0 (Swepub:uu)ollekors |
700 | 1 | a Wierup, Nilsu Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-nwi |
700 | 1 | a Ibberson, M.u SIB Swiss Inst Bioinformat, Vital IT Grp, Lausanne, Switzerland.,Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Solimena, M.u Tech Univ Dresden, Paul Langerhans Inst Dresden, Munich Univ Hosp Carl Gustav Carus, Helmholtz Ctr, Dresden, Germany.;Tech Univ Dresden, Fac Med, Dresden, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;Max Planck Inst Mol Cell Biol & Genet, MPI CBG, Dresden, Germany.,German Center for Diabetes Research4 aut |
700 | 1 | a Marchetti, P.u Univ Pisa, Cisanello Univ Hosp, Dept Clin & Expt Med, Pisa, Italy.,University Hospital of Pisa4 aut |
700 | 1 | a Wollheim, Claesu Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Geneva4 aut0 (Swepub:lu)med-cwe |
700 | 1 | a Artner, Isabellau Lund University,Lunds universitet,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Endocrine Cell Differentiation and Function,Lund University Research Groups4 aut0 (Swepub:lu)med-iba |
700 | 1 | a Mulder, Hindriku Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)medk-hmu |
700 | 1 | a Hansson, Olau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)medk-oha |
700 | 1 | a Otonkoski, T.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.;Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland.,University of Helsinki4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Prasad, Rashmi Bu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)med-rpa |
710 | 2 | a Translationell muskelforskningb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Life Science Allianced : Life Science Alliance, LLCg 5:12q 5:12x 2575-1077 |
856 | 4 | u https://doi.org/10.26508/lsa.202201376y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1693072/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.26508/lsa.202201376x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/318613 |
856 | 4 8 | u https://doi.org/10.26508/lsa.202201376 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483882 |
856 | 4 8 | u https://lup.lub.lu.se/record/6578fb3c-e71f-4d4b-ae6e-4d28314eebe8 |
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