Sökning: (WFRF:(Kaaks R)) mspu:(article) pers:(Tjonneland A)
> (2020-2024) >
Metabolic perturbat...
Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study
-
- Stepien, M. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Keski-Rahkonen, P. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Kiss, A. (författare)
- International Agency for Research on Cancer, World Health Organization
-
visa fler...
-
- Robinot, N. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Duarte-Salles, T. (författare)
- International Agency for Research on Cancer, World Health Organization,Institut Universitari d’Investigació en Atenció Primària Jordi Gol
-
- Murphy, N. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Perlemuter, G. (författare)
- Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay,Antoine-Béclère Hospital
-
- Viallon, V. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Tjonneland, A. (författare)
- Danish Cancer Society
-
- Rostgaard-Hansen, A. L. (författare)
- Danish Cancer Society
-
- Dahm, C. C. (författare)
- Aarhus University
-
- Overvad, K. (författare)
- Aalborg University Hospital,Aarhus University
-
- Boutron-Ruault, M. C. (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy
-
- Mancini, F. R. (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy
-
- Mahannat-Saleh, Y. (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
-
- Aleksandrova, K. (författare)
- German Institute of Human Nutrition
-
- Kaaks, R. (författare)
- German Cancer Research Centre
-
- Kühn, Tilman (författare)
- German Cancer Research Centre
-
- Trichopoulou, A. (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
-
- Karakatsani, A. (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
-
- Panico, S. (författare)
- University of Naples Federico II
-
- Tumino, R. (författare)
- Provincial Health Authority (ASP) Ragusa
-
- Palli, D. (författare)
- Cancer Research and Prevention Institute (ISPO)
-
- Tagliabue, G. (författare)
- Istituto Nazionale dei Tumori
-
- Naccarati, A. (författare)
- Italian Institute for Genomic Medicine (IIGM)
-
- Vermeulen, R. C. H. (författare)
- Utrecht University
-
- Bueno-de-Mesquita, H. B. (författare)
- University Medical Center Utrecht,Imperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM)
-
- Weiderpass, E. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Skeie, G. (författare)
- UiT The Arctic University of Norway, Tromsø
-
- Quiros, J. R. (författare)
- Public Health Directorate
-
- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
-
- Mokoroa, O. (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute
-
- Sala, N. (författare)
- Catalan Institute of Oncology
-
- Sanchez, M. J. (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP),International Agency for Research on Cancer, World Health Organization
-
- Huerta, J. M. (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
-
- Winkvist, Anna, 1962 (författare)
- Umeå University,Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Avdelningen för hållbar hälsa,The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
-
- Harlid, Sophia, 1978- (författare)
- Umeå University,Umeå universitet,Onkologi
-
- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
-
- Sjöberg, Klas (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
-
- Schmidt, J. A. (författare)
- University of Oxford
-
- Wareham, N. (författare)
- University of Cambridge
-
- Khaw, K. T. (författare)
- University of Cambridge
-
- Ferrari, P. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Rothwell, J. A. (författare)
- Institut Gustave Roussy,International Agency for Research on Cancer, World Health Organization
-
- Gunter, M. (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Riboli, E. (författare)
- Imperial College London
-
- Scalbert, A. (författare)
- International Agency for Research on Cancer, World Health Organization
-
Jenab, M. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-08-28
- 2021
- Engelska.
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 148:3, s. 609-625
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed forN1-acetylspermidine, isatin,p-hydroxyphenyllactic acid, tyrosine, sphingosine,l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, gamma-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways associated with steroid metabolism and immunity and specific dietary and environmental exposures in HCC development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- hepatocellular carcinoma
- prospective observational cohort
- untargeted
- metabolomics
- body-mass index
- cancer prevention
- androgen receptor
- alpha-tocopherol
- beta-carotene
- breast-cancer
- liver-disease
- bile-acids
- vitamin-e
- serum
- Oncology
- hepatocellular carcinoma
- untargeted metabolomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Stepien, M.
-
Keski-Rahkonen, ...
-
Kiss, A.
-
Robinot, N.
-
Duarte-Salles, T ...
-
Murphy, N.
-
visa fler...
-
Perlemuter, G.
-
Viallon, V.
-
Tjonneland, A.
-
Rostgaard-Hansen ...
-
Dahm, C. C.
-
Overvad, K.
-
Boutron-Ruault, ...
-
Mancini, F. R.
-
Mahannat-Saleh, ...
-
Aleksandrova, K.
-
Kaaks, R.
-
Kühn, Tilman
-
Trichopoulou, A.
-
Karakatsani, A.
-
Panico, S.
-
Tumino, R.
-
Palli, D.
-
Tagliabue, G.
-
Naccarati, A.
-
Vermeulen, R. C. ...
-
Bueno-de-Mesquit ...
-
Weiderpass, E.
-
Skeie, G.
-
Quiros, J. R.
-
Ardanaz, Eva
-
Mokoroa, O.
-
Sala, N.
-
Sanchez, M. J.
-
Huerta, J. M.
-
Winkvist, Anna, ...
-
Harlid, Sophia, ...
-
Ohlsson, Bodil
-
Sjöberg, Klas
-
Schmidt, J. A.
-
Wareham, N.
-
Khaw, K. T.
-
Ferrari, P.
-
Rothwell, J. A.
-
Gunter, M.
-
Riboli, E.
-
Scalbert, A.
-
Jenab, M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Göteborgs universitet
-
Umeå universitet
-
Lunds universitet