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Outcomes of relapse...
Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
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- Harrysson, S. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Eloranta, S. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Ekberg, Sara (författare)
- Karolinska Institutet,Karolinska Institute
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- Enblad, Gunilla (författare)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- El-Galaly, T. C. (författare)
- Karolinska Institutet,Karolinska Institute,Aalborg University Hospital
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- Sander, B. (författare)
- Karolinska Institutet
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- Sonnevi, K. (författare)
- Karolinska Institutet
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- Andersson, Per-Ola, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Hematol, Borås, Sweden.;Gothenburg Univ, Sahlgrenska Acad, Gothenburg, Sweden.,Sahlgrenska Academy
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- Jerkeman, Mats (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund
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Smedby, K. E. (författare)
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(creator_code:org_t)
- 2022-04-25
- 2022
- Engelska.
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 198:2, s. 267-277
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Several recently published trials investigate novel therapies for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). To estimate the benefit of these therapies in the real-world setting, comprehensive data on patients treated in clinical routine are needed. We report outcomes for 736 R/R DLBCL patients identified among all curatively treated DLBCL patients in Sweden in the period 2007-2014. Survival and associations with disease characteristics, second-line treatment and fulfilment of chimaeric antigen receptor (CAR) T-cell trial criteria were assessed. Median overall survival (OS) was 6.6 months (<= 70 years 9.6 months, >70 years 4.9 months). Early relapse (<= 12 months) was strongly associated with selection of less intensive treatment and poor survival. Among patients of at most 70 years of age, 63% started intensive second-line treatment and 34% received autologous stem cell transplantation (ASCT). Two-year OS among transplanted patients was 56% (early relapse <= 12 months 40%, late relapse >12 months 66%). A minority of patients 76 years (n = 178/506, 35%) fitted CAR T trial criteria. Median progression-free survival (PFS) for patients with early relapse fitting trial criteria was 4.8 months. In conclusion, most R/R DLBCL manifest early and are often ineligible for or cannot complete intensive regimens resulting in dismal survival. Real-world patients eligible for CAR T trials also did poorly, providing a benchmark for efficacy of novel therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- clinical research
- epidemiology
- non-Hodgkin lymphoma
- stem cell
- transplantation
- tumour immunotherapy
- chemotherapy plus rituximab
- predict survival
- chop
- transplantation
- failure
- classification
- multicenter
- therapy
- impact
- Hematology
- clinical research
- stem cell transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Harrysson, S.
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Eloranta, S.
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Ekberg, Sara
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Enblad, Gunilla
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El-Galaly, T. C.
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Sander, B.
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visa fler...
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Sonnevi, K.
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Andersson, Per-O ...
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Jerkeman, Mats
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Smedby, K. E.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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British Journal ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet