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Clinical outcomes a...
Clinical outcomes and sick leave in relation to UDCA treatment in Swedish patients with primary biliary cholangitis
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- Henriksson, Ida, 1980- (author)
- Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Udumyan, Ruzan, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- Nilsson, E. (author)
- Department of Clinical Sciences, Gastroenterology Division, Skåne University Hospital, Lund, Sweden
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- Onnerhag, K. (author)
- Department of Gastroenterology and Hepatology, Skåne University Hospital, Malmö, Sweden
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- Rorsman, F. (author)
- Department of Gastroenterology and Hepatology, Uppsala University Hospital, Uppsala, Sweden
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- Werner, M. (author)
- Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden
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- Marschall, Hanns-Ulrich, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
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- Wahlin, S. (author)
- Karolinska Institutet
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- Nyhlin, Nils, 1971- (author)
- Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2022-08-21
- 2023
- English.
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 58:1, s. 70-75
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Abstract
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- Objectives Primary biliary cholangitis (PBC) is an autoimmune liver disease that may progress into liver cirrhosis. Ursodeoxycholic acid (UDCA) is known to prevent or delay the disease progression, but little is known about work incapacity in PBC patients. We aimed to compare clinical outcomes (transplantation-free survival; cirrhosis development) and sick leave in patients with PBC with and without UDCA therapy. Methods The medical records of 526 patients with PBC diagnosed from 2004 to 2016 were reviewed retrospectively. Sick leave data retrieved from the Swedish Social Insurance Agency were analysed for a sub-cohort of patients and matched controls. Cox regression was used for analysis of clinical outcomes. Logistic and conditional logistic regressions were used for sick leave analysis. Results A total of 10.6% of patients died and 3.4% received liver transplantation over a median follow-up time of 5.7 years. UDCA-untreated patients (HR 3.62 (95%CI 2.02-6.49)) and UDCA non-responders (HR 3.78 (95% CI 1.87-7.66)) had higher mortality or transplantation rates than UDCA responders. Patients with PBC had higher odds of sick leave (OR 2.50; 95% CI 1.69-3.70) than matched controls. Untreated patients were more likely to be on sick leave (OR 3.22; 95% CI 1.12-9.25) two years after diagnosis than UDCA responders. Conclusion Both untreated patients and UDCA non-responders had lower liver transplantation-free survival rates than UDCA responders. Patients with PBC were more likely to be on sick leave compared to matched controls from the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Cholestatic liver disease
- transplantation-free survival
- work ability
- cirrhosis
- ursodeoxycholic acid
- quality-of-life
- ursodeoxycholic acid
- biochemical response
- cirrhosis
- prognosis
- mortality
- age
- Gastroenterology & Hepatology
- Cholestatic liver disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Henriksson, Ida, ...
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Udumyan, Ruzan, ...
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Nilsson, E.
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Onnerhag, K.
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Rorsman, F.
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Werner, M.
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Marschall, Hanns ...
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Wahlin, S.
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Nyhlin, Nils, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet