Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

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Wang, Z.Icahn School of Medicine at Mount Sinai (author)

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Article/chapterEnglish2022

Publisher, publication year, extent ...

2022-09-07
Springer Science and Business Media LLC,2022

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LIBRIS-ID:oai:gup.ub.gu.se/319001
https://gup.ub.gu.se/publication/319001URI
https://doi.org/10.1038/s41588-022-01165-1DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489990URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150677600URI
https://lup.lub.lu.se/record/3ed8047d-6831-4b5c-acd0-5ca8bf379b56URI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

Subject headings and genre

NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Idrottsvetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Sport and Fitness Sciences hsv//eng
apolipoprotein-e genotype
ld score regression
gene-expression
exercise
complex
performance
gwas
heritability
mortality
fitness
Genetics & Heredity

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Emmerich, AndrewUppsala universitet,Molekylärbiologi(Swepub:uu)andem552 (author)
Pillon, N. J.Karolinska Institutet (author)
Moore, T. (author)
Hemerich, D. (author)
Metzendorf, ChristophUppsala universitet,Molekylära verktyg och funktionsgenomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)chmet515 (author)
Mazzaferro, EugeniaUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylära verktyg och funktionsgenomik(Swepub:uu)eugma242 (author)
Broos, S. (author)
Ahluwalia, T. S. (author)
Bartz, T. M. (author)
Ameur, AdamLund University,Lunds universitet,Karolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-csc (author)
Bielak, L. F. (author)
Chong, M. (author)
Chu, A. Y. (author)
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Dorajoo, R. (author)
Dueker, N. D. (author)
Kasbohm, E.Karolinska Institutet (author)
Feenstra, B. (author)
Feitosa, M. F. (author)
Gieger, C. (author)
Graff, M. (author)
Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlomat (author)
Haller, T. (author)
Hartwig, F. P. (author)
Hillis, D. A. (author)
Huikari, V. (author)
Heard-Costa, N. (author)
Holzapfel, C. (author)
Jackson, A. U. (author)
Johansson, ÅsaUppsala universitet,Genomik och neurobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)asjoh108 (author)
Jorgensen, A. M. (author)
Kaakinen, M. A. (author)
Karlsson, R.Karolinska Institutet (author)
Kerr, K. F. (author)
Kim, B. (author)
Koolhaas, C. M. (author)
Kutalik, Z. (author)
Lagou, V. (author)
Lind, P. A. (author)
Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlomat (author)
Lyytikainen, L. P.Karolinska Institutet (author)
Orho-Melander, M.Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
Metzendorf, C. (author)
Monroe, K. R. (author)
Pacolet, A. (author)
Perusse, L. (author)
Pool, R. (author)
Richmond, R. C. (author)
Rivera, N. V.Karolinska Institutet (author)
Robiou-Du-Pont, S. (author)
Schraut, K. E. (author)
Schulz, C. A. (author)
Stringham, H. M.Uppsala University,Science for Life Laboratory (SciLifeLab) (author)
Tanaka, T. (author)
Teumer, A. (author)
Turman, C. (author)
Van der Most, P. J. (author)
Vanmunster, M. (author)
Van Rooij, F. J. A. (author)
Van Vliet-Ostaptchouk, J. V. (author)
Zhang, X. S. (author)
Zhao, J. H. (author)
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Balkhiyarova, Z. (author)
Balslev-Harder, M. N. (author)
Enroth, Stefan,1976-Uppsala universitet,Genomik och neurobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stenr451 (author)
Beilby, J. (author)
Blangero, J. (author)
Boomsma, D. I. (author)
Brage, S. (author)
Braund, P. S. (author)
Brody, J. A. (author)
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Ekelund, U. (author)
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Cole, J. W. (author)
Collins, F. S. (author)
Cupples, L. A. (author)
Esko, T. (author)
Sonestedt, E.Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-eso (author)
Faul, J. D. (author)
Fernandez-Rhodes, L. (author)
Fohner, A. E. (author)
Franco, O. H. (author)
Galesloot, T. E. (author)
Gordon, S. D. (author)
Grarup, N. (author)
Hartman, C. A. (author)
Heiss, G. (author)
Hui, J. (author)
Illig, T. (author)
Jago, R.Karolinska Institutet (author)
James, A. (author)
Joshi, P. K. (author)
Jung, T. (author)
Kahonen, M. (author)
Kilpelainen, T. O. (author)
Koh, W. P. (author)
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Kraft, P. P. (author)
Kuusisto, J. (author)
Launer, L. J. (author)
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Nolte, I. M. (author)
Pedersen, N. L. (author)
Peters, A. (author)
Peyser, P. A. (author)
Power, C. (author)
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Siggeirsdottir, K. (author)
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Sonestedt, E. (author)
Strom, M. (author)
Tai, E. S. (author)
Teo, K. K. (author)
Thorand, B. (author)
Tonjes, A. (author)
Tremblay, A. (author)
Uitterlinden, A. G. (author)
Vangipurapu, J. (author)
Van Schoor, N. (author)
Volker, U. (author)
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Xu, H. C. (author)
Young, K. L. (author)
Yuan, J. M. (author)
Zillikens, M. C. (author)
Zonderman, A. B. (author)
Ameur, A. (author)
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Chasman, D. I. (author)
Smith, G. D. (author)
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Fox, C. (author)
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Gudnason, V. (author)
Gyllensten, UlfUppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi(Swepub:uu)ulfgyll (author)
Hansen, T. (author)
Hayward, C. (author)
Horta, B. L. (author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
Oldehinkel, A. J. (author)
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Penninx, Bwjh (author)
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Wichmann, H. E. (author)
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den Hoed, Marcel,1980-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylära verktyg och funktionsgenomik(Swepub:uu)marde358 (author)
Icahn School of Medicine at Mount SinaiMolekylärbiologi (creator_code:org_t)
Lifelines Cohort Study

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By the author/editor: Wang, Z.; Emmerich, Andrew; Pillon, N. J.; Moore, T.; Hemerich, D.; Metzendorf, Chri ...; show more...; Mazzaferro, Euge ...; Broos, S.; Ahluwalia, T. S.; Bartz, T. M.; Ameur, Adam; Bielak, L. F.; Chong, M.; Chu, A. Y.; Berry, D.; Dorajoo, R.; Dueker, N. D.; Kasbohm, E.; Feenstra, B.; Feitosa, M. F.; Gieger, C.; Graff, M.; Lorentzon, Matti ...; Haller, T.; Hartwig, F. P.; Hillis, D. A.; Huikari, V.; Heard-Costa, N.; Holzapfel, C.; Jackson, A. U.; Johansson, Åsa; Jorgensen, A. M.; Kaakinen, M. A.; Karlsson, R.; Kerr, K. F.; Kim, B.; Koolhaas, C. M.; Kutalik, Z.; Lagou, V.; Lind, P. A.; Lyytikainen, L. ...; Orho-Melander, M ...; Metzendorf, C.; Monroe, K. R.; Pacolet, A.; Perusse, L.; Pool, R.; Richmond, R. C.; Rivera, N. V.; Robiou-Du-Pont, ...; Schraut, K. E.; Schulz, C. A.; Stringham, H. M.; Tanaka, T.; Teumer, A.; Turman, C.; Van der Most, P. ...; Vanmunster, M.; Van Rooij, F. J. ...; Van Vliet-Ostapt ...; Zhang, X. S.; Zhao, J. H.; Zhao, W.; Balkhiyarova, Z.; Balslev-Harder, ...; Enroth, Stefan, ...; Beilby, J.; Blangero, J.; Boomsma, D. I.; Brage, S.; Braund, P. S.; Brody, J. A.; Bruinenberg, M.; Ekelund, U.; Liu, C. T.; Cole, J. W.; Collins, F. S.; Cupples, L. A.; Esko, T.; Sonestedt, E.; Faul, J. D.; Fernandez-Rhodes ...; Fohner, A. E.; Franco, O. H.; Galesloot, T. E.; Gordon, S. D.; Grarup, N.; Hartman, C. A.; Heiss, G.; Hui, J.; Illig, T.; Jago, R.; James, A.; Joshi, P. K.; Jung, T.; Kahonen, M.; Kilpelainen, T. ...; Koh, W. P.; Kolcic, I.; Kraft, P. P.; Kuusisto, J.; Launer, L. J.; Li, A. H.; Linneberg, A.; Luan, J. A.; Vidal, P. M.; Medland, S. E.; Milaneschi, Y.; Moscati, A.; Musk, B.; Nelson, C. P.; Nolte, I. M.; Pedersen, N. L.; Peters, A.; Peyser, P. A.; Power, C.; Raitakari, O. T.; Reedik, M.; Reiner, A. P.; Ridker, P. M.; Rudan, I.; Ryan, K.; Sarzynski, M. A.; Scott, L. J.; Scott, R. A.; Sidney, S.; Siggeirsdottir, ...; Smith, A. V.; Smith, J. A.; Strom, M.; Tai, E. S.; Teo, K. K.; Thorand, B.; Tonjes, A.; Tremblay, A.; Uitterlinden, A. ...; Vangipurapu, J.; Van Schoor, N.; Volker, U.; Willemsen, G.; Williams, K.; Wong, Q.; Xu, H. C.; Young, K. L.; Yuan, J. M.; Zillikens, M. C.; Zonderman, A. B.; Ameur, A.; Bandinelli, S.; Bis, J. C.; Boehnke, M.; Bouchard, C.; Chasman, D. I.; Smith, G. D.; De Geus, E. J. C ...; Deldicque, L.; Dorr, M.; Evans, M. K.; Ferrucci, L.; Fornage, M.; Fox, C.; Garland, T.; Gudnason, V.; Gyllensten, Ulf; Hansen, T.; Hayward, C.; Horta, B. L.; Hypponen, E.; Jarvelin, M. R.; Johnson, W. C.; Kardia, S. L. R.; Kiemeney, L. A.; Laakso, M.; Langenberg, C.; Lehtimaki, T.; Le Marchand, L.; Magnusson, P. K. ...; Martin, N. G.; Melbye, M.; Metspalu, A.; Meyre, D.; North, K. E.; Ohlsson, Claes, ...; Oldehinkel, A. J ...; Pare, G.; Park, T.; Pedersen, O.; Penninx, Bwjh; Pers, T. H.; Polasek, O.; Prokopenko, I.; Rotimi, C. N.; Samani, N. J.; Sim, X.; Snieder, H.; Sorensen, T. I. ...; Spector, T. D.; Timpson, N. J.; Van Dam, R. M.; Van der Velde, N ...; Van Duijn, C. M.; Vollenweider, P.; Volzke, H.; Voortman, T.; Waeber, G.; Wareham, N. J.; Weir, D. R.; Wichmann, H. E.; Wilson, J. F.; Hevener, A. L.; Krook, A.; Zierath, J. R.; Thomis, M. A. I.; Loos, R. J. F.; den Hoed, Marcel ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Sport and Fitnes ...

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