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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14021naa a2203217 4500 | |
| 001 | oai:gup.ub.gu.se/319001 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-489990 | |
| 009 | oai:prod.swepub.kib.ki.se:150677600 | |
| 009 | oai:lup.lub.lu.se:3ed8047d-6831-4b5c-acd0-5ca8bf379b56 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3190012 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-022-01165-12 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4899902 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1506776002 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/3ed8047d-6831-4b5c-acd0-5ca8bf379b562 URI |
| 040 | a (SwePub)gud (SwePub)uud (SwePub)kid (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Z.u Icahn School of Medicine at Mount Sinai4 aut |
| 245 | 1 0 | a Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention |
| 264 | c 2022-09-07 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Idrottsvetenskap0 (SwePub)303082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Sport and Fitness Sciences0 (SwePub)303082 hsv//eng |
| 653 | a apolipoprotein-e genotype | |
| 653 | a ld score regression | |
| 653 | a gene-expression | |
| 653 | a exercise | |
| 653 | a complex | |
| 653 | a performance | |
| 653 | a gwas | |
| 653 | a heritability | |
| 653 | a mortality | |
| 653 | a fitness | |
| 653 | a Genetics & Heredity | |
| 700 | 1 | a Emmerich, Andrewu Uppsala universitet,Molekylärbiologi4 aut0 (Swepub:uu)andem552 |
| 700 | 1 | a Pillon, N. J.u Karolinska Institutet4 aut |
| 700 | 1 | a Moore, T.4 aut |
| 700 | 1 | a Hemerich, D.4 aut |
| 700 | 1 | a Metzendorf, Christophu Uppsala universitet,Molekylära verktyg och funktionsgenomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)chmet515 |
| 700 | 1 | a Mazzaferro, Eugeniau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylära verktyg och funktionsgenomik4 aut0 (Swepub:uu)eugma242 |
| 700 | 1 | a Broos, S.4 aut |
| 700 | 1 | a Ahluwalia, T. S.4 aut |
| 700 | 1 | a Bartz, T. M.4 aut |
| 700 | 1 | a Ameur, Adamu Lund University,Lunds universitet,Karolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-csc |
| 700 | 1 | a Bielak, L. F.4 aut |
| 700 | 1 | a Chong, M.4 aut |
| 700 | 1 | a Chu, A. Y.4 aut |
| 700 | 1 | a Berry, D.4 aut |
| 700 | 1 | a Dorajoo, R.4 aut |
| 700 | 1 | a Dueker, N. D.4 aut |
| 700 | 1 | a Kasbohm, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Feenstra, B.4 aut |
| 700 | 1 | a Feitosa, M. F.4 aut |
| 700 | 1 | a Gieger, C.4 aut |
| 700 | 1 | a Graff, M.4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Haller, T.4 aut |
| 700 | 1 | a Hartwig, F. P.4 aut |
| 700 | 1 | a Hillis, D. A.4 aut |
| 700 | 1 | a Huikari, V.4 aut |
| 700 | 1 | a Heard-Costa, N.4 aut |
| 700 | 1 | a Holzapfel, C.4 aut |
| 700 | 1 | a Jackson, A. U.4 aut |
| 700 | 1 | a Johansson, Åsau Uppsala universitet,Genomik och neurobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)asjoh108 |
| 700 | 1 | a Jorgensen, A. M.4 aut |
| 700 | 1 | a Kaakinen, M. A.4 aut |
| 700 | 1 | a Karlsson, R.u Karolinska Institutet4 aut |
| 700 | 1 | a Kerr, K. F.4 aut |
| 700 | 1 | a Kim, B.4 aut |
| 700 | 1 | a Koolhaas, C. M.4 aut |
| 700 | 1 | a Kutalik, Z.4 aut |
| 700 | 1 | a Lagou, V.4 aut |
| 700 | 1 | a Lind, P. A.4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Lyytikainen, L. P.u Karolinska Institutet4 aut |
| 700 | 1 | a Orho-Melander, M.u Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
| 700 | 1 | a Metzendorf, C.4 aut |
| 700 | 1 | a Monroe, K. R.4 aut |
| 700 | 1 | a Pacolet, A.4 aut |
| 700 | 1 | a Perusse, L.4 aut |
| 700 | 1 | a Pool, R.4 aut |
| 700 | 1 | a Richmond, R. C.4 aut |
| 700 | 1 | a Rivera, N. V.u Karolinska Institutet4 aut |
| 700 | 1 | a Robiou-Du-Pont, S.4 aut |
| 700 | 1 | a Schraut, K. E.4 aut |
| 700 | 1 | a Schulz, C. A.4 aut |
| 700 | 1 | a Stringham, H. M.u Uppsala University,Science for Life Laboratory (SciLifeLab)4 aut |
| 700 | 1 | a Tanaka, T.4 aut |
| 700 | 1 | a Teumer, A.4 aut |
| 700 | 1 | a Turman, C.4 aut |
| 700 | 1 | a Van der Most, P. J.4 aut |
| 700 | 1 | a Vanmunster, M.4 aut |
| 700 | 1 | a Van Rooij, F. J. A.4 aut |
| 700 | 1 | a Van Vliet-Ostaptchouk, J. V.4 aut |
| 700 | 1 | a Zhang, X. S.4 aut |
| 700 | 1 | a Zhao, J. H.4 aut |
| 700 | 1 | a Zhao, W.4 aut |
| 700 | 1 | a Balkhiyarova, Z.4 aut |
| 700 | 1 | a Balslev-Harder, M. N.4 aut |
| 700 | 1 | a Enroth, Stefan,d 1976-u Uppsala universitet,Genomik och neurobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stenr451 |
| 700 | 1 | a Beilby, J.4 aut |
| 700 | 1 | a Blangero, J.4 aut |
| 700 | 1 | a Boomsma, D. I.4 aut |
| 700 | 1 | a Brage, S.4 aut |
| 700 | 1 | a Braund, P. S.4 aut |
| 700 | 1 | a Brody, J. A.4 aut |
| 700 | 1 | a Bruinenberg, M.4 aut |
| 700 | 1 | a Ekelund, U.4 aut |
| 700 | 1 | a Liu, C. T.4 aut |
| 700 | 1 | a Cole, J. W.4 aut |
| 700 | 1 | a Collins, F. S.4 aut |
| 700 | 1 | a Cupples, L. A.4 aut |
| 700 | 1 | a Esko, T.4 aut |
| 700 | 1 | a Sonestedt, E.u Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso |
| 700 | 1 | a Faul, J. D.4 aut |
| 700 | 1 | a Fernandez-Rhodes, L.4 aut |
| 700 | 1 | a Fohner, A. E.4 aut |
| 700 | 1 | a Franco, O. H.4 aut |
| 700 | 1 | a Galesloot, T. E.4 aut |
| 700 | 1 | a Gordon, S. D.4 aut |
| 700 | 1 | a Grarup, N.4 aut |
| 700 | 1 | a Hartman, C. A.4 aut |
| 700 | 1 | a Heiss, G.4 aut |
| 700 | 1 | a Hui, J.4 aut |
| 700 | 1 | a Illig, T.4 aut |
| 700 | 1 | a Jago, R.u Karolinska Institutet4 aut |
| 700 | 1 | a James, A.4 aut |
| 700 | 1 | a Joshi, P. K.4 aut |
| 700 | 1 | a Jung, T.4 aut |
| 700 | 1 | a Kahonen, M.4 aut |
| 700 | 1 | a Kilpelainen, T. O.4 aut |
| 700 | 1 | a Koh, W. P.4 aut |
| 700 | 1 | a Kolcic, I.4 aut |
| 700 | 1 | a Kraft, P. P.4 aut |
| 700 | 1 | a Kuusisto, J.4 aut |
| 700 | 1 | a Launer, L. J.4 aut |
| 700 | 1 | a Li, A. H.4 aut |
| 700 | 1 | a Linneberg, A.4 aut |
| 700 | 1 | a Luan, J. A.4 aut |
| 700 | 1 | a Vidal, P. M.4 aut |
| 700 | 1 | a Medland, S. E.4 aut |
| 700 | 1 | a Milaneschi, Y.4 aut |
| 700 | 1 | a Moscati, A.4 aut |
| 700 | 1 | a Musk, B.4 aut |
| 700 | 1 | a Nelson, C. P.4 aut |
| 700 | 1 | a Nolte, I. M.4 aut |
| 700 | 1 | a Pedersen, N. L.4 aut |
| 700 | 1 | a Peters, A.4 aut |
| 700 | 1 | a Peyser, P. A.4 aut |
| 700 | 1 | a Power, C.4 aut |
| 700 | 1 | a Raitakari, O. T.4 aut |
| 700 | 1 | a Reedik, M.4 aut |
| 700 | 1 | a Reiner, A. P.4 aut |
| 700 | 1 | a Ridker, P. M.4 aut |
| 700 | 1 | a Rudan, I.4 aut |
| 700 | 1 | a Ryan, K.4 aut |
| 700 | 1 | a Sarzynski, M. A.4 aut |
| 700 | 1 | a Scott, L. J.4 aut |
| 700 | 1 | a Scott, R. A.4 aut |
| 700 | 1 | a Sidney, S.4 aut |
| 700 | 1 | a Siggeirsdottir, K.4 aut |
| 700 | 1 | a Smith, A. V.4 aut |
| 700 | 1 | a Smith, J. A.4 aut |
| 700 | 1 | a Sonestedt, E.4 aut |
| 700 | 1 | a Strom, M.4 aut |
| 700 | 1 | a Tai, E. S.4 aut |
| 700 | 1 | a Teo, K. K.4 aut |
| 700 | 1 | a Thorand, B.4 aut |
| 700 | 1 | a Tonjes, A.4 aut |
| 700 | 1 | a Tremblay, A.4 aut |
| 700 | 1 | a Uitterlinden, A. G.4 aut |
| 700 | 1 | a Vangipurapu, J.4 aut |
| 700 | 1 | a Van Schoor, N.4 aut |
| 700 | 1 | a Volker, U.4 aut |
| 700 | 1 | a Willemsen, G.4 aut |
| 700 | 1 | a Williams, K.4 aut |
| 700 | 1 | a Wong, Q.4 aut |
| 700 | 1 | a Xu, H. C.4 aut |
| 700 | 1 | a Young, K. L.4 aut |
| 700 | 1 | a Yuan, J. M.4 aut |
| 700 | 1 | a Zillikens, M. C.4 aut |
| 700 | 1 | a Zonderman, A. B.4 aut |
| 700 | 1 | a Ameur, A.4 aut |
| 700 | 1 | a Bandinelli, S.4 aut |
| 700 | 1 | a Bis, J. C.4 aut |
| 700 | 1 | a Boehnke, M.4 aut |
| 700 | 1 | a Bouchard, C.4 aut |
| 700 | 1 | a Chasman, D. I.4 aut |
| 700 | 1 | a Smith, G. D.4 aut |
| 700 | 1 | a De Geus, E. J. C.4 aut |
| 700 | 1 | a Deldicque, L.4 aut |
| 700 | 1 | a Dorr, M.4 aut |
| 700 | 1 | a Evans, M. K.4 aut |
| 700 | 1 | a Ferrucci, L.4 aut |
| 700 | 1 | a Fornage, M.4 aut |
| 700 | 1 | a Fox, C.4 aut |
| 700 | 1 | a Garland, T.4 aut |
| 700 | 1 | a Gudnason, V.4 aut |
| 700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Hansen, T.4 aut |
| 700 | 1 | a Hayward, C.4 aut |
| 700 | 1 | a Horta, B. L.4 aut |
| 700 | 1 | a Hypponen, E.4 aut |
| 700 | 1 | a Jarvelin, M. R.4 aut |
| 700 | 1 | a Johnson, W. C.4 aut |
| 700 | 1 | a Kardia, S. L. R.4 aut |
| 700 | 1 | a Kiemeney, L. A.4 aut |
| 700 | 1 | a Laakso, M.4 aut |
| 700 | 1 | a Langenberg, C.4 aut |
| 700 | 1 | a Lehtimaki, T.4 aut |
| 700 | 1 | a Le Marchand, L.4 aut |
| 700 | 1 | a Magnusson, P. K. E.4 aut |
| 700 | 1 | a Martin, N. G.4 aut |
| 700 | 1 | a Melbye, M.4 aut |
| 700 | 1 | a Metspalu, A.4 aut |
| 700 | 1 | a Meyre, D.4 aut |
| 700 | 1 | a North, K. E.4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Oldehinkel, A. J.4 aut |
| 700 | 1 | a Orho-Melander, M.4 aut |
| 700 | 1 | a Pare, G.4 aut |
| 700 | 1 | a Park, T.4 aut |
| 700 | 1 | a Pedersen, O.4 aut |
| 700 | 1 | a Penninx, Bwjh4 aut |
| 700 | 1 | a Pers, T. H.4 aut |
| 700 | 1 | a Polasek, O.4 aut |
| 700 | 1 | a Prokopenko, I.4 aut |
| 700 | 1 | a Rotimi, C. N.4 aut |
| 700 | 1 | a Samani, N. J.4 aut |
| 700 | 1 | a Sim, X.4 aut |
| 700 | 1 | a Snieder, H.4 aut |
| 700 | 1 | a Sorensen, T. I. A.4 aut |
| 700 | 1 | a Spector, T. D.4 aut |
| 700 | 1 | a Timpson, N. J.4 aut |
| 700 | 1 | a Van Dam, R. M.4 aut |
| 700 | 1 | a Van der Velde, N.4 aut |
| 700 | 1 | a Van Duijn, C. M.4 aut |
| 700 | 1 | a Vollenweider, P.4 aut |
| 700 | 1 | a Volzke, H.4 aut |
| 700 | 1 | a Voortman, T.4 aut |
| 700 | 1 | a Waeber, G.4 aut |
| 700 | 1 | a Wareham, N. J.4 aut |
| 700 | 1 | a Weir, D. R.4 aut |
| 700 | 1 | a Wichmann, H. E.4 aut |
| 700 | 1 | a Wilson, J. F.4 aut |
| 700 | 1 | a Hevener, A. L.4 aut |
| 700 | 1 | a Krook, A.4 aut |
| 700 | 1 | a Zierath, J. R.4 aut |
| 700 | 1 | a Thomis, M. A. I.4 aut |
| 700 | 1 | a Loos, R. J. F.4 aut |
| 700 | 1 | a den Hoed, Marcel,d 1980-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylära verktyg och funktionsgenomik4 aut0 (Swepub:uu)marde358 |
| 710 | 2 | a Icahn School of Medicine at Mount Sinaib Molekylärbiologi4 org |
| 710 | 2 | a Lifelines Cohort Study |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 54:9, s. 1332-1344q 54:9<1332-1344x 1061-4036x 1546-1718 |
| 856 | 4 | u https://doi.org/10.1038/s41588-022-01165-1y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1716861/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://dx.doi.org/10.1038/s41588-022-01165-1x freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/319001 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-022-01165-1 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489990 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150677600 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3ed8047d-6831-4b5c-acd0-5ca8bf379b56 |
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- Wang, Z.
- Emmerich, Andrew
- Pillon, N. J.
- Moore, T.
- Hemerich, D.
- Metzendorf, Chri ...
- show more...
- Mazzaferro, Euge ...
- Broos, S.
- Ahluwalia, T. S.
- Bartz, T. M.
- Ameur, Adam
- Bielak, L. F.
- Chong, M.
- Chu, A. Y.
- Berry, D.
- Dorajoo, R.
- Dueker, N. D.
- Kasbohm, E.
- Feenstra, B.
- Feitosa, M. F.
- Gieger, C.
- Graff, M.
- Lorentzon, Matti ...
- Haller, T.
- Hartwig, F. P.
- Hillis, D. A.
- Huikari, V.
- Heard-Costa, N.
- Holzapfel, C.
- Jackson, A. U.
- Johansson, Åsa
- Jorgensen, A. M.
- Kaakinen, M. A.
- Karlsson, R.
- Kerr, K. F.
- Kim, B.
- Koolhaas, C. M.
- Kutalik, Z.
- Lagou, V.
- Lind, P. A.
- Lyytikainen, L. ...
- Orho-Melander, M ...
- Metzendorf, C.
- Monroe, K. R.
- Pacolet, A.
- Perusse, L.
- Pool, R.
- Richmond, R. C.
- Rivera, N. V.
- Robiou-Du-Pont, ...
- Schraut, K. E.
- Schulz, C. A.
- Stringham, H. M.
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- Bruinenberg, M.
- Ekelund, U.
- Liu, C. T.
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- Galesloot, T. E.
- Gordon, S. D.
- Grarup, N.
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- Hui, J.
- Illig, T.
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- James, A.
- Joshi, P. K.
- Jung, T.
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- Koh, W. P.
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- Kraft, P. P.
- Kuusisto, J.
- Launer, L. J.
- Li, A. H.
- Linneberg, A.
- Luan, J. A.
- Vidal, P. M.
- Medland, S. E.
- Milaneschi, Y.
- Moscati, A.
- Musk, B.
- Nelson, C. P.
- Nolte, I. M.
- Pedersen, N. L.
- Peters, A.
- Peyser, P. A.
- Power, C.
- Raitakari, O. T.
- Reedik, M.
- Reiner, A. P.
- Ridker, P. M.
- Rudan, I.
- Ryan, K.
- Sarzynski, M. A.
- Scott, L. J.
- Scott, R. A.
- Sidney, S.
- Siggeirsdottir, ...
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- Uitterlinden, A. ...
- Vangipurapu, J.
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- Volker, U.
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- Yuan, J. M.
- Zillikens, M. C.
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- Ameur, A.
- Bandinelli, S.
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- Bouchard, C.
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- De Geus, E. J. C ...
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- Fornage, M.
- Fox, C.
- Garland, T.
- Gudnason, V.
- Gyllensten, Ulf
- Hansen, T.
- Hayward, C.
- Horta, B. L.
- Hypponen, E.
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- Johnson, W. C.
- Kardia, S. L. R.
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- Wareham, N. J.
- Weir, D. R.
- Wichmann, H. E.
- Wilson, J. F.
- Hevener, A. L.
- Krook, A.
- Zierath, J. R.
- Thomis, M. A. I.
- Loos, R. J. F.
- den Hoed, Marcel ...
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- and Genetics
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- Articles in the publication
- Nature Genetics
- By the university
- University of Gothenburg
- Uppsala University
- Karolinska Institutet
- Lund University
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