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Association of Epic...
Association of Epicardial Adipose Tissue with Proteomics, Coronary Flow Reserve, Cardiac Structure and Function, and Quality of Life in Heart Failure with Preserved Ejection Fraction: Insights from the PROMIS-HFpEF study.
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- Venkateshvaran, Ashwin (author)
- Karolinska Institutet
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- Faxen, Ulrika Ljung (author)
- Karolinska Institutet
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Hage, Camilla (author)
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Michaëlsson, Erik (author)
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- Svedlund, Sara (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Saraste, Antti (author)
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Beussink-Nelson, Lauren (author)
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Fermer, Maria Lagerstrom (author)
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- Gan, Li-Ming, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Tromp, Jasper (author)
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Lam, Carolyn S P (author)
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Shah, Sanjiv J (author)
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- Lund, Lars H (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-10-20
- 2022
- English.
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In: European journal of heart failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 24:12, s. 2251-2260
- Related links:
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Abstract
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- Epicardial Adipose Tissue (EAT) may play a role in the pathophysiology of Heart Failure with preserved Ejection Fraction (HFpEF). We investigated associations of EAT with proteomics, coronary flow reserve (CFR), cardiac structure and function, and quality of life (QoL) in the prospective multinational PROMIS-HFpEF cohort.EAT was measured by echocardiography in 182 patients and defined as increased if ≥9mm. Proteins were measured using high-throughput proximity extension assays. Microvascular dysfunction was evaluated with Doppler-based CFR, cardiac structural and functional indices with echocardiography and QoL by Kansas City Cardiomyopathy Questionnaire (KCCQ). Patients with increased EAT (n=54; 30%) had higher body mass index (BMI) [32 (28-40) vs. 27 (23-30) kg/m2; p <0.001], lower NT-proBNP [466 (193-1133) vs. 1120 (494-1990) pg/mL; p <0.001], smaller indexed left ventricular (LV) end-diastolic and left atrial (LA) volumes and tendency to lower KCCQ score. Non-indexed LV/LA volumes did not differ between groups. When adjusted for BMI, EAT remained associated with LV septal wall thickness [Coeff 1.02, 95% CI 1.00-1.04; p=0.018] and mitral E wave deceleration time [Coeff 1.03, 95% CI 1.01-1.05; p=0.005]. Increased EAT was associated with proteomic markers of adipose biology and inflammation, insulin resistance, endothelial dysfunction, and dyslipidemia but not significantly with CFR.Increased EAT was associated with cardiac structural alterations and proteins expressing adiposity, inflammation, lower insulin sensitivity and endothelial dysfunction related to HFpEF pathology, probably driven by general obesity. Potential local mechanical or paracrine effects mediated by EAT remain to be elucidated. This article is protected by copyright. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Echocardiography
- Heart failure
- Microvascular dysfunction
- Proteomics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Venkateshvaran, ...
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Faxen, Ulrika Lj ...
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Hage, Camilla
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Michaëlsson, Eri ...
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Svedlund, Sara
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Saraste, Antti
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show more...
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Beussink-Nelson, ...
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Fermer, Maria La ...
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Gan, Li-Ming, 19 ...
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Tromp, Jasper
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Lam, Carolyn S P
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Shah, Sanjiv J
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Lund, Lars H
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg
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Karolinska Institutet