Search: WFRF:(Andersson Micael)
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Longitudinal Dopami...
Longitudinal Dopamine D2 Receptor Changes and Cerebrovascular Health in Aging
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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- Johansson, Jarkko (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Wåhlin, Anders (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för tillämpad fysik och elektronik,Radiofysik
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- Salami, Alireza (author)
- Karolinska Institutet,Stockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Aging Research Center, Karolinska Institutet & Stockholm University,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden
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- Köhncke, Ylva (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Germany
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- Brandmaier, Andreas M. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany;
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- Andersson, Micael (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Lövdén, Martin, 1972 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Department of Psychology, University of Gothenburg, Sweden.
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Neurology. - 1526-632X .- 0028-3878. ; 99
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
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- BACKGROUND AND OBJECTIVES: Cross-sectional studies suggest marked dopamine (DA) decline in aging, but longitudinal evidence is lacking. The aim of this study was to estimate within-person decline rates for DA D2-like receptors (DRD2) in aging and examine factors that may contribute to individual differences in DRD2 decline rates. METHODS: We investigated 5-year within-person changes in DRD2 availability in a sample of older adults. At both occasions, PET with 11C-raclopride and MRI were used to measure DRD2 availability in conjunction with structural and vascular brain integrity. RESULTS: Longitudinal analyses of the sample (baseline: n = 181, ages: 64-68 years, 100 men and 81 women; 5-year follow-up: n = 129, 69 men and 60 women) revealed aging-related striatal and extrastriatal DRD2 decline, along with marked individual differences in rates of change. Notably, the magnitude of striatal DRD2 decline was ∼50% of past cross-sectional estimates, suggesting that the DRD2 decline rate has been overestimated in past cross-sectional studies. Significant DRD2 reductions were also observed in select extrastriatal regions, including hippocampus, orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC). Distinct profiles of correlated DRD2 changes were found across several associative regions (ACC, dorsal striatum, and hippocampus) and in the reward circuit (nucleus accumbens and OFC). DRD2 losses in associative regions were associated with white matter lesion progression, whereas DRD2 losses in limbic regions were related to reduced cortical perfusion. DISCUSSION: These findings provide the first longitudinal evidence for individual and region-specific differences of DRD2 decline in older age and support the hypothesis that cerebrovascular factors are linked to age-related dopaminergic decline.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
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Neurology
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- By the author/editor
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Karalija, Nina, ...
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Johansson, Jarkk ...
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Papenberg, Goran
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Wåhlin, Anders
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Salami, Alireza
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Köhncke, Ylva
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Brandmaier, Andr ...
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Andersson, Micae ...
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Axelsson, Jan, 1 ...
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Riklund, Katrine ...
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Lövdén, Martin, ...
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Lindenberger, Ul ...
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Bäckman, Lars
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Nyberg, Lars, 19 ...
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg
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Umeå University
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Stockholm University
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Karolinska Institutet