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Cohort profile: the...
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
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- Svanes, C. (författare)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
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- Johannessen, A. (författare)
- Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
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- Bertelsen, R. J. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Oral Helath Ctr Expertise Western Norway, Bergen, Norway.
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- Dharmage, S. (författare)
- Univ Melbourne, Sch Populat & Global Hlth, Allergy & Hlth Unit, Melbourne, Vic, Australia.
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- Benediktsdottir, B. (författare)
- Univ Iceland, Med Fac, Reykjavik, Iceland.;Landspitali Univ Hosp Reykjavik, Dept Sleep, Reykjavik, Iceland.
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- Bråbäck, Lennart (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, Umeå, Sweden.
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- Gislason, T. (författare)
- Landspitali Univ Hosp Reykjavik, Dept Sleep, Reykjavik, Iceland.
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- Holm, Mathias, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Inst Med,Occupat & Environm Med, Gothenburg, Sweden.
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- Jogi, O. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
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- Janson, Christer (författare)
- Uppsala universitet,Klinisk fysiologi,Lung- allergi- och sömnforskning
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi
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- Martinez-Moratalla, J. (författare)
- Complejo Hosp Univ Albacete, Serv Neumol, Albacete, Spain.;Univ Castilla La Mancha, Fac Med, Campus Albacete, Albacete, Spain.
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- Oudin, Anna (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, Umeå, Sweden.
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- Sanchez-Ramos, J. L. (författare)
- Univ Huelva, Dept Nursing, Huelva, Spain.
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- Timm, S. (författare)
- Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.;Univ Hosp Southern Denmark, Kolding Hosp, Res Unit, Kolding, Denmark.
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Janson, C. (författare)
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- Real, F. G. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway.
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- Schlunssen, V. (författare)
- Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth Work Environm & Hlth, Aarhus, Denmark.;Natl Res Ctr Working Environm, Copenhagen, Denmark.
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Rhinessa Int Collaboration, Rhinessa Int Collaboration (författare)
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Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway. Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway. (creator_code:org_t)
- 2022-06-02
- 2022
- Engelska.
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Ingår i: Bmj Open. - : BMJ. - 2044-6055. ; 12:6
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014-17 in a questionnaire study (N=8818, age 18-53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20-44 years old, at 8-10 years intervals. Study protocols are harmonised across generations. Findings to date Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father's exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father's exposures to offspring health and disease through impact on offspring DNA methylation. Future plans Follow-up is planned at 5-8 years intervals, first in 2021-2023. Linkage with health registries contributes to follow-up of the cohort.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- Allergy
- Chronic airways disease
- EPIDEMIOLOGY
- PUBLIC HEALTH
- transgenerational responses
- epigenetic inheritance
- 2 generations
- asthma
- symptoms
- exposure
- smoking
- impact
- General & Internal Medicine
- Allergy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Bmj Open
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Till lärosätets databas
- Av författaren/redakt...
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Svanes, C.
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Johannessen, A.
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Bertelsen, R. J.
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Dharmage, S.
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Benediktsdottir, ...
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Bråbäck, Lennart
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Gislason, T.
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Holm, Mathias, 1 ...
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Jogi, O.
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Janson, Christer
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Malinovschi, And ...
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Martinez-Moratal ...
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Oudin, Anna
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Sanchez-Ramos, J ...
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Timm, S.
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Janson, C.
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Real, F. G.
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Schlunssen, V.
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Rhinessa Int Col ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Bmj Open
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet