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Cerebral Metabolic ...
Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Mary Ann Liebert Inc,2023
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/320400
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https://gup.ub.gu.se/publication/320400URI
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https://doi.org/10.1089/neu.2022.0161DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this association are not entirely established. In this pre-planned analysis of the BIOmarkers of AXonal injury after Traumatic Brain Injury (BIO-AX-TBI) prospective study, we investigated any associations of LP ratio with brain structure volume change rates at 1 year. Fourteen subjects underwent acute-phase (0-96 h post-TBI) CMD monitoring and had longitudinal magnetic resonance imaging (MRI) quantification of brain volume loss between the subacute phase (14 days to 6 weeks) and 1 year after TBI, recalculated as an annual rate. On average, CMD showed an elevated (>25) LP ratio (31 [interquartile range (IQR) 24-34]), indicating acute cerebral metabolic dysfunction. Annualized whole brain and total gray matter (GM) volume change rates were abnormally reduced (-3.2% [-9.3 to -2.2] and -1.9% [-4.4 to 1.7], respectively). Reduced annualized total GM volume correlated significantly with elevated CMD LP ratio (Spearman's rho = -0.68, p-value = 0.01) and low CMD glucose (rho = 0.66, p-value = 0.01). After adjusting for age, admission Glasgow Coma Scale (GCS) score and CT Marshall score, CMD LP ratio remained strongly associated with 1-year total GM volume change rate (p < 0.001; multi-variable analysis). No relationship was found between WM volume changes and CMD metabolites. We demonstrate a strong association between acute post-traumatic cerebral metabolic dysfunction and 1-year gray matter atrophy, reinforcing the role of CMD LP ratio as an early biomarker of poor long-term recovery after TBI.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Magnoni, S.
(författare)
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Miroz, J. P.
(författare)
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Corredor-Jerez, R.
(författare)
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Bertolini, G.
(författare)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(författare)
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Graham, N.
(författare)
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Sharp, D.
(författare)
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Oddo, M.
(författare)
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Dunet, V.
(författare)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Neurotrauma: Mary Ann Liebert Inc40:5-6, s. 472-4810897-71511557-9042
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Bernini, A.
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Magnoni, S.
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Miroz, J. P.
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Corredor-Jerez, ...
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Bertolini, G.
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Zetterberg, Henr ...
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visa fler...
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Graham, N.
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Sharp, D.
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Oddo, M.
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Dunet, V.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Neurovetenskaper
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Göteborgs universitet