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  • Gils, Charlotte (author)

NT-proBNP on Cobas h 232 in point-of-care testing: Performance in the primary health care versus in the hospital laboratory

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-08-11
  • Informa UK Limited,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:7e43632c-1c3c-4c16-8c6a-acff7ef6482e
  • https://lup.lub.lu.se/record/8074253URI
  • https://doi.org/10.3109/00365513.2015.1066846DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a hospital laboratory (n = 107). NT-proBNP was measured on-site on Cobas h 232 instruments both in primary health care centres and at the hospital laboratory and all samples were also analyzed with a comparison method at the hospital. Precision, trueness, accuracy, and lot-variation were determined at different concentration levels and evaluated according to acceptance criteria. Furthermore user-friendliness was assessed by questionnaires. Results. For Cobas h 232 repeatability CV was 8.5-10.7% in the hospital setting and 5.3-10.0% in the primary health care and within the analytical quality specifications, but higher than with the comparison method (<4%). NT-proBNP results obtained in primary health care were significantly higher than by the hospital comparison method (bias ranged from 14.3-23.7%), whereas there was no significant bias when Cobas h 232 was used in the hospital setting (bias ranged from 4.9 to 7.0%). User-friendliness of Cobas h 232 was overall acceptable. Conclusion. Cobas h 232 point-of-care instrument for measurement of NT-proBNP performed satisfactorily with regard to precision, user-friendliness, and lot-variation. A decrease in NT-proBNP levels observed in samples transported to a central laboratory needs further attention and investigation.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ramanathan, Ramshanker (author)
  • Breindahl, Torben (author)
  • Brokner, Mette (author)
  • Christiansen, Anne L. (author)
  • Eng, Oyvin (author)
  • Hammer, Ida J. (author)
  • Herrera, Catherine B. (author)
  • Jansen, Aina (author)
  • Langsjoen, Eva C. (author)
  • Lokkebo, Elisabeth S. (author)
  • Osestad, Toril (author)
  • Schroder, Anne D. (author)
  • Walther, LisaLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klke-lm0 (author)
  • Avdelningen för klinisk kemi och farmakologiInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Clinical & Laboratory Investigation: Informa UK Limited75:7, s. 602-6091502-76860036-5513

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