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  • Sjölin, Gabriel,1979-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Dept. of Surgery, University Hospital, Örebro, Sweden,Örebro Univ Hosp, Fac Med & Hlth, Örebro, Sweden.;Örebro Univ, Dept Surg, S-70185 Örebro, Sweden.;Univ Hosp, S-70185 Örebro, Sweden. (author)

Long term outcome after toxic nodular goitre

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-11-01
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/320592
  • https://gup.ub.gu.se/publication/320592URI
  • https://doi.org/10.1186/s13044-022-00138-0DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102140URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491697URI
  • https://lup.lub.lu.se/record/649a7d81-9b9c-4086-91e7-e5bd82009592URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:236316779URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:Swedish governmentSwedish county councils, the ALF-agreement ALFGBG-717311 + ALFGBG-790271Faculty of Medicine at Lund UniversitySkåne Research FoundationResearch Funds of Skåne University HospitalNyckelfondenResearch foundation in the Uppsala and Örebro Region
  • Background: The purpose of treating toxic nodular goitre (TNG) is to reverse hyperthyroidism, prevent recurrent disease, relieve symptoms and preserve thyroid function. Treatment efficacies and long-term outcomes of antithyroid drugs (ATD), radioactive iodine (RAI) or surgery vary in the literature. Symptoms often persist for a long time following euthyroidism, and previous studies have demonstrated long-term cognitive and quality of life (QoL) impairments. We report the outcome of treatment, rate of cure (euthyroidism and hypothyroidism), and QoL in an unselected TNG cohort. Methods: TNG patients (n = 638) de novo diagnosed between 2003-2005 were invited to engage in a 6-10-year follow-up study. 237 patients responded to questionnaires about therapies, demographics, comorbidities, and quality of life (ThyPRO). Patients received ATD, RAI, or surgery according clinical guidelines. Results: The fraction of patients cured with one RAI treatment was 89%, and 93% in patients treated with surgery. The rate of levothyroxine supplementation for RAI and surgery, at the end of the study period, was 58% respectively 64%. Approximately 5% of the patients needed three or more RAI treatments to be cured. The patients had worse thyroid-related QoL scores, in a broad spectrum, than the general population. Conclusion: One advantage of treating TNG with RAI over surgery might be lost due to the seemingly similar incidence of hypothyroidism. The need for up to five treatments is rarely described and indicates that the treatment of TNG can be more complex than expected. This circumstance and the long-term QoL impairments are reminders of the chronic nature of hyperthyroidism from TNG.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Watt, T.Department of Medical Endocrinology Rigshospitalet, Copenhagen, Denmark; Internal Medicine Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark,Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.;Copenhagen Univ Hosp, Internal Med Herlev Gentofte Hosp, Copenhagen, Denmark. (author)
  • Byström, Kristina,1961-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Medicine, University Hospital, Örebro, Sweden,Univ Hosp, S-70185 Örebro, Sweden.;Örebro Univ, Dept Med, Örebro, Sweden.(Swepub:oru)kbm (author)
  • Calissendorff, J.Karolinska Institute,Karolinska University Hospital (author)
  • Cramon, P. K.Department of Medical Endocrinology Rigshospitalet, Copenhagen, Denmark; Internal Medicine Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark,Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.;Copenhagen Univ Hosp, Internal Med Herlev Gentofte Hosp, Copenhagen, Denmark. (author)
  • Nyström, Helena Filipsson,1966University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Dept. of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Wallenberg Center for Molecular and Translational Medicine, Göteborg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden.;Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.(Swepub:gu)xfilih (author)
  • Hallengren, BengtLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-bha (author)
  • Holmberg, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; ANOVA, Karolinska University Hospital, Stockholm, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Karolinska Univ Hosp, ANOVA, Stockholm, Sweden.(Swepub:gu)xhmats (author)
  • Khamisi, SelwanUppsala University,Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University Hospital(Swepub:uu)selkh262 (author)
  • Lantz, MikaelLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-mla (author)
  • Planck, TerezaLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-tvo (author)
  • Torring, O.Karolinska Institute (author)
  • Wallin, Göran,1952-Karolinska Institutet,Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Surgery, University Hospital, Örebro, Sweden,Örebro Univ Hosp, Fac Med & Hlth, Örebro, Sweden.;Örebro Univ, Dept Surg, S-70185 Örebro, Sweden.;Univ Hosp, S-70185 Örebro, Sweden.(Swepub:oru)gwn (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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  • In:Thyroid Research: Springer Science and Business Media LLC15:11756-6614

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