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Virtual Ontogeny of...
Virtual Ontogeny of Cortical Growth Preceding Mental Illness
- Article/chapterEnglish2022
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LIBRIS-ID:oai:gup.ub.gu.se/320906
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https://gup.ub.gu.se/publication/320906URI
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https://doi.org/10.1016/j.biopsych.2022.02.959DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151236548URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life. Methods: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. Results: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. Conclusions: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
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Shin, J.
(author)
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Abé, C.Karolinska Institutet
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Agartz, I.Karolinska Institutet
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Alloza, C.
(author)
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Alnæs, D.
(author)
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Ambrogi, S.
(author)
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Antonucci, L. A.
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Arango, C.
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Arolt, V.
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Auzias, G.
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Ayesa-Arriola, R.
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Banaj, N.
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Banaschewski, T.
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Bandeira, C.
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Başgöze, Z.
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Cupertino, R. B.
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Bau, C. H. D.
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Bauer, J.
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Baumeister, S.
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Bernardoni, F.
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Bertolino, A.
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Bonnin, C. D. M.
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Brandeis, D.
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Brem, S.
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Bruggemann, J.
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Bülow, R.
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Bustillo, J. R.
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Calderoni, S.
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Calvo, R.
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Canales-Rodríguez, E. J.
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Cannon, D. M.
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Carmona, S.
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Carr, V. J.
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Catts, S. V.
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Chenji, S.
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Chew, Q. H.
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Coghill, D.
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Connolly, C. G.
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Conzelmann, A.
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Craven, A. R.
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Crespo-Facorro, B.
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Cullen, K.
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Dahl, A.
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Dannlowski, U.
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Davey, C. G.
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Deruelle, C.
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Díaz-Caneja, C. M.
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Dohm, K.
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Ehrlich, S.
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Epstein, J.
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Erwin-Grabner, T.
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Eyler, L. T.
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Fedor, J.
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Fitzgerald, J.
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Foran, W.
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Ford, J. M.
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Fortea, L.
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Fuentes-Claramonte, P.
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Fullerton, J.
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Furlong, L.
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Gallagher, L.
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Gao, B.
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Gao, S.
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Goikolea, J. M.
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Gotlib, I.
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Goya-Maldonado, R.
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Grabe, H. J.
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Green, M.
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Grevet, E. H.
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Groenewold, N. A.
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Grotegerd, D.
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Gruber, O.
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Haavik, J.
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Hahn, T.
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Harrison, B. J.
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Heindel, W.
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Henskens, F.
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Heslenfeld, D. J.
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Hilland, E.
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Hoekstra, P. J.
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Hohmann, S.
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Holz, N.
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Howells, F. M.
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Ipser, J. C.
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Jahanshad, N.
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Jakobi, B.
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Jansen, A.
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Janssen, J.
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Jonassen, R.
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Kaiser, A.
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Kaleda, V.
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Karantonis, J.
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King, J. A.
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Kircher, T.
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Kochunov, P.
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Koopowitz, S. M.
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Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt
(author)
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Landrø, N. I.
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Lawrie, S.
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Lebedeva, I.
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Luna, B.
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Lundervold, A. J.
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MacMaster, F. P.
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Maglanoc, L. A.
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Mathalon, D. H.
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McDonald, C.
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McIntosh, A.
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Meinert, S.
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Michie, P. T.
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Mitchell, P.
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Moreno-Alcázar, A.
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Mowry, B.
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Muratori, F.
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Nabulsi, L.
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Nenadić, I.
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O'Gorman Tuura, R.
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Oosterlaan, J.
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Overs, B.
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Pantelis, C.
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Parellada, M.
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Pariente, J. C.
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Pauli, P.
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Pergola, G.
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Piarulli, F. M.
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Picon, F.
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Piras, F.
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Pomarol-Clotet, E.
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Pretus, C.
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Quidé, Y.
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Radua, J.
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Ramos-Quiroga, J. A.
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Rasser, P. E.
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Reif, A.
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Retico, A.
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Roberts, G.
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Rossell, S.
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Rovaris, D. L.
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Rubia, K.
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Sacchet, M.
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Salavert, J.
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Salvador, R.
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Sarró, S.
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Sawa, A.
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Schall, U.
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Scott, R.
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Selvaggi, P.
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Silk, T.
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Sim, K.
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Skoch, A.
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Spalletta, G.
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Spaniel, F.
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Stein, D. J.
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Steinsträter, O.
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Stolicyn, A.
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Takayanagi, Y.
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Tamm, L.
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Tavares, M.
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Teumer, A.
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Thiel, K.
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Thomopoulos, S. I.
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Tomecek, D.
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Tomyshev, A. S.
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Tordesillas-Gutiérrez, D.
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Tosetti, M.
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Uhlmann, A.
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Van Rheenen, T.
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Vazquez-Bourgón, J.
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Vernooij, M. W.
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Vieta, E.
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Vilarroya, O.
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Weickert, C.
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Weickert, T.
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Westlye, L. T.
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Whalley, H.
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Willinger, D.
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Winter, A.
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Wittfeld, K.
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Yang, T. T.
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Yoncheva, Y.
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Zijlmans, J. L.
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Hoogman, M.
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Franke, B.
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van Rooij, D.
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Buitelaar, J.
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Ching, C. R. K.
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Andreassen, O. A.
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Pozzi, E.
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Veltman, D.
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Schmaal, L.
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van Erp, T. G. M.
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Turner, J.
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Castellanos, F. X.
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Pausova, Z.
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Thompson, P.
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Paus, T.
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Biological Psychiatry: Elsevier BV92:4, s. 299-3130006-32231873-2402
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Patel, Y.
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Shin, J.
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Abé, C.
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Agartz, I.
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Alloza, C.
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Alnæs, D.
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show more...
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Ambrogi, S.
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Antonucci, L. A.
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Arango, C.
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Arolt, V.
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Auzias, G.
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Ayesa-Arriola, R ...
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Banaj, N.
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Banaschewski, T.
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Bandeira, C.
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Başgöze, Z.
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Cupertino, R. B.
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Bau, C. H. D.
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Bauer, J.
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Baumeister, S.
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Bernardoni, F.
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Bertolino, A.
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Bonnin, C. D. M.
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Brandeis, D.
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Brem, S.
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Bruggemann, J.
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Bülow, R.
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Bustillo, J. R.
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Calderoni, S.
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Calvo, R.
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Canales-Rodrígue ...
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Cannon, D. M.
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Carmona, S.
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Carr, V. J.
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Catts, S. V.
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Chenji, S.
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Chew, Q. H.
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Coghill, D.
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Connolly, C. G.
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Conzelmann, A.
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Craven, A. R.
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Crespo-Facorro, ...
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Cullen, K.
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Dahl, A.
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Davey, C. G.
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Dohm, K.
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Ehrlich, S.
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Epstein, J.
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Ford, J. M.
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Fuentes-Claramon ...
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Fullerton, J.
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Furlong, L.
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Gallagher, L.
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Gao, B.
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Gao, S.
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Goikolea, J. M.
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Gotlib, I.
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Goya-Maldonado, ...
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Grabe, H. J.
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Green, M.
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Grevet, E. H.
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Groenewold, N. A ...
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Grotegerd, D.
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Gruber, O.
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Haavik, J.
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Hahn, T.
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Harrison, B. J.
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Heindel, W.
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Henskens, F.
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Heslenfeld, D. J ...
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Hilland, E.
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Hoekstra, P. J.
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Hohmann, S.
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Holz, N.
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Howells, F. M.
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Ipser, J. C.
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Jahanshad, N.
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Jakobi, B.
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Jansen, A.
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Janssen, J.
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Jonassen, R.
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Kaiser, A.
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Kaleda, V.
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Karantonis, J.
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King, J. A.
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Kircher, T.
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Kochunov, P.
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Koopowitz, S. M.
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Landén, Mikael, ...
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Landrø, N. I.
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Lawrie, S.
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Lebedeva, I.
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Luna, B.
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Lundervold, A. J ...
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MacMaster, F. P.
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Maglanoc, L. A.
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Mathalon, D. H.
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McDonald, C.
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McIntosh, A.
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Meinert, S.
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Michie, P. T.
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Mitchell, P.
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Moreno-Alcázar, ...
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Mowry, B.
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Muratori, F.
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Nabulsi, L.
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Nenadić, I.
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Oosterlaan, J.
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Overs, B.
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Pantelis, C.
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Parellada, M.
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Pariente, J. C.
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Pauli, P.
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Pergola, G.
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Piarulli, F. M.
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Picon, F.
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Piras, F.
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Pomarol-Clotet, ...
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Pretus, C.
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Quidé, Y.
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Radua, J.
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Ramos-Quiroga, J ...
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Rasser, P. E.
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Reif, A.
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Retico, A.
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Roberts, G.
-
Rossell, S.
-
Rovaris, D. L.
-
Rubia, K.
-
Sacchet, M.
-
Salavert, J.
-
Salvador, R.
-
Sarró, S.
-
Sawa, A.
-
Schall, U.
-
Scott, R.
-
Selvaggi, P.
-
Silk, T.
-
Sim, K.
-
Skoch, A.
-
Spalletta, G.
-
Spaniel, F.
-
Stein, D. J.
-
Steinsträter, O.
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Stolicyn, A.
-
Takayanagi, Y.
-
Tamm, L.
-
Tavares, M.
-
Teumer, A.
-
Thiel, K.
-
Thomopoulos, S. ...
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Tomecek, D.
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Tomyshev, A. S.
-
Tordesillas-Guti ...
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Tosetti, M.
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Uhlmann, A.
-
Van Rheenen, T.
-
Vazquez-Bourgón, ...
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Vernooij, M. W.
-
Vieta, E.
-
Vilarroya, O.
-
Weickert, C.
-
Weickert, T.
-
Westlye, L. T.
-
Whalley, H.
-
Willinger, D.
-
Winter, A.
-
Wittfeld, K.
-
Yang, T. T.
-
Yoncheva, Y.
-
Zijlmans, J. L.
-
Hoogman, M.
-
Franke, B.
-
van Rooij, D.
-
Buitelaar, J.
-
Ching, C. R. K.
-
Andreassen, O. A ...
-
Pozzi, E.
-
Veltman, D.
-
Schmaal, L.
-
van Erp, T. G. M ...
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Turner, J.
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Castellanos, F. ...
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Pausova, Z.
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Thompson, P.
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Paus, T.
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- MEDICAL AND HEALTH SCIENCES
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Biological Psych ...
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University of Gothenburg
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Karolinska Institutet