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  • Razis, E. (author)

Assessment of the management of carcinomatous meningitis from breast cancer globally: a study by the Breast International Group Brain Metastasis Task Force

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/320912
  • https://gup.ub.gu.se/publication/320912URI
  • https://doi.org/10.1016/j.esmoop.2022.100483DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Carcinomatous meningitis (CM) is a severe complication of breast cancer. The Breast International Group (BIG) carried out a survey to describe the approach to CM internationally. Patients and methods: A questionnaire on the management of CM was developed by the Brain Metastases Task Force of BIG and distributed to its groups, requesting one answer per group site. Results: A total of 241 sites responded, 119 from Europe, 9 from North America, 39 from Central/South America, 58 from Asia, and 16 in Australia/New Zealand, with 24.5% being general hospitals with oncology units, 44.4% university hospitals, 22.4% oncology centers, and 8.7% private hospitals. About 56.0% of sites reported seeing <5 cases annually with 60.6% reporting no increase in the number of cases of CM recently. Nearly 63.1% of sites investigate for CM when a patient has symptoms or radiological evidence, while 33.2% investigate only for symptoms. For diagnosis, 71.8% of sites required a positive cerebrospinal fluid cytology, while magnetic resonance imaging findings were sufficient in 23.7% of sites. Roughly 97.1% of sites treat CM and 51.9% also refer patients to palliative care. Intrathecal therapy is used in 41.9% of sites, mainly with methotrexate (74.3%). As many as 20 centers have a national registry for patients with breast cancer with central nervous system metastases and of those 5 have one for CM. Most (90.9%) centers would be interested in participating in a registry as well as in studies for CM, the latter preferably (62.1%) breast cancer subtype specific. Conclusions: This is the first study to map out the approach to CM from breast cancer globally. Although guidelines with level 1 evidence are lacking, there is a high degree of homogeneity in the approach to CM globally and great interest for conducting studies in this area.

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  • Escudero, M. J. (author)
  • Palmieri, C. (author)
  • Mueller, V. (author)
  • Bartsch, R. (author)
  • Rossi, G. (author)
  • Gampenrieder, S. P. (author)
  • Kolberg, H. C. (author)
  • Zdenkowski, N. (author)
  • Pavic, M. (author)
  • Connolly, R. M. (author)
  • Rosset, L. (author)
  • Arcuri, J. (author)
  • Tesch, H. (author)
  • Vallejos, C. (author)
  • Retamales, J. (author)
  • Musolino, A. (author)
  • Del Mastro, L. (author)
  • Christodoulou, C. (author)
  • Aebi, S. (author)
  • Paluch-Shimon, S. (author)
  • Gupta, S. (author)
  • Ohno, S. (author)
  • Macpherson, I. (author)
  • Ekholm, MariaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xekhma (author)
  • Zaman, K. (author)
  • Vidal, M. (author)
  • Chakiba, C. (author)
  • Fumagalli, D. (author)
  • Thulin, A. (author)
  • Witzel, I. (author)
  • Kotecki, N. (author)
  • Gil-Gil, M. (author)
  • Linderholm, B. (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för laboratoriemedicin (creator_code:org_t)

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  • In:ESMO Open: Elsevier BV7:32059-7029

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