Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.

• Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.

Nyckelord

Blood Pressure

physiology

Blood Pressure Monitoring

Ambulatory

trends

Congresses as Topic

trends

Denervation

methods

trends

Humans

Hypertension

diagnosis

physiopathology

surgery

Internationality

Kidney

innervation

physiology

Randomized Controlled Trials as Topic

methods

Review Literature as Topic

Sympathectomy

methods

trends

Sympathetic Nervous System

physiology

physiopathology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)