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A yeast living ance...
A yeast living ancestor reveals the origin of genomic introgressions
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- D'Angiolo, M. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- De Chiara, M. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Yue, J. X. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Irizar, A. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Stenberg, Simon (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU)
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- Persson, Karl, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Llored, A. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Barre, B. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Schacherer, J. (author)
- Université de Strasbourg,University of Strasbourg
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- Marangoni, R. (author)
- Universita di Pisa,University of Pisa
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- Gilson, E. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Warringer, Jonas, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Liti, G. (author)
- Université Côte d'Azur,University of Côte d'Azur
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(creator_code:org_t)
- 2020-11-11
- 2020
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 587, s. 420-425
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Abstract
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- A yeast clonal descendant of an ancient hybridization event is identified and sheds light on the early evolution of the Saccharomyces cerevisiae Alpechin lineage and its abundant Saccharomyces paradoxus introgressions. Genome introgressions drive evolution across the animal(1), plant(2) and fungal(3) kingdoms. Introgressions initiate from archaic admixtures followed by repeated backcrossing to one parental species. However, how introgressions arise in reproductively isolated species, such as yeast(4), has remained unclear. Here we identify a clonal descendant of the ancestral yeast hybrid that founded the extant Saccharomyces cerevisiae Alpechin lineage(5), which carries abundant Saccharomyces paradoxus introgressions. We show that this clonal descendant, hereafter defined as a 'living ancestor', retained the ancestral genome structure of the first-generation hybrid with contiguous S. cerevisiae and S. paradoxus subgenomes. The ancestral first-generation hybrid underwent catastrophic genomic instability through more than a hundred mitotic recombination events, mainly manifesting as homozygous genome blocks generated by loss of heterozygosity. These homozygous sequence blocks rescue hybrid fertility by restoring meiotic recombination and are the direct origins of the introgressions present in the Alpechin lineage. We suggest a plausible route for introgression evolution through the reconstruction of extinct stages and propose that genome instability allows hybrids to overcome reproductive isolation and enables introgressions to emerge.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Astronomi, astrofysik och kosmologi (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Astronomy, Astrophysics and Cosmology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Keyword
- saccharomyces-cerevisiae
- reproductive isolation
- mitotic recombination
- population genomics
- hybrid sterility
- hybridization
- sequence
- dynamics
- shape
- Science & Technology - Other Topics
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- ref (subject category)
- art (subject category)
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Nature
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D'Angiolo, M.
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De Chiara, M.
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Yue, J. X.
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Irizar, A.
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Stenberg, Simon
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Persson, Karl, 1 ...
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show more...
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Llored, A.
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Barre, B.
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Schacherer, J.
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Marangoni, R.
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Gilson, E.
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Warringer, Jonas ...
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Liti, G.
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show less...
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University of Gothenburg
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Chalmers University of Technology