Search: (WFRF:(Harbst Katja)) conttype:(refereed) srt2:(2020-2024) >
Tertiary lymphoid s...
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
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- Cabrita, Rita (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Lauss, Martin (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Sanna, Adriana (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Donia, Marco (author)
- Copenhagen University Hospital
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- Skaarup Larsen, Mathilde (author)
- Herlev Hospital
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- Mitra, Shamik (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Johansson, Iva (author)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Phung, Bengt (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Harbst, Katja (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Vallon-Christersson, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- van Schoiack, Alison (author)
- NanoString Technologies
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- Lövgren, Kristina (author)
- Lund University,Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,The Liquid Biopsy and Tumor Progression in Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Warren, Sarah (author)
- NanoString Technologies
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Olsson, Håkan (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Pietras, Kristian (author)
- Lund University,Lunds universitet,Experimentell onkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Experimental oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ingvar, Christian (author)
- Skåne University Hospital
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- Isaksson, Karolin (author)
- Skåne University Hospital
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- Schadendorf, Dirk (author)
- University Hospital Essen
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- Schmidt, Henrik (author)
- Aarhus University Hospital
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- Bastholt, Lars (author)
- Odense University Hospital
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- Carneiro, Ana (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Wargo, Jennifer A (author)
- Anderson Medical Center,University of Texas
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- Svane, Inge Marie (author)
- Copenhagen University Hospital
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- Jönsson, Göran (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Nature Publishing Group, 2020
- 2020
- English.
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In: Nature. - : Nature Publishing Group. - 1476-4687 .- 0028-0836. ; 577:7791, s. 561-565
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T cells in antitumour responses has thoroughly been studied, other immune cells remain insufficiently explored. Here we use clinical samples of metastatic melanomas to investigate the role of B cells in antitumour responses, and find that the co-occurrence of tumour-associated CD8+ T cells and CD20+ B cells is associated with improved survival, independently of other clinical variables. Immunofluorescence staining of CXCR5 and CXCL13 in combination with CD20 reveals the formation of tertiary lymphoid structures in these CD8+CD20+ tumours. We derived a gene signature associated with tertiary lymphoid structures, which predicted clinical outcomes in cohorts of patients treated with immune checkpoint blockade. Furthermore, B-cell-rich tumours were accompanied by increased levels of TCF7+ naive and/or memory T cells. This was corroborated by digital spatial-profiling data, in which T cells in tumours without tertiary lymphoid structures had a dysfunctional molecular phenotype. Our results indicate that tertiary lymphoid structures have a key role in the immune microenvironment in melanoma, by conferring distinct T cell phenotypes. Therapeutic strategies to induce the formation of tertiary lymphoid structures should be explored to improve responses to cancer immunotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Antigens
- CD20
- metabolism
- B-Lymphocytes
- immunology
- metabolism
- B7-H1 Antigen
- antagonists & inhibitors
- CD8-Positive T-Lymphocytes
- immunology
- metabolism
- Chemokine CXCL13
- metabolism
- Humans
- Immunologic Memory
- immunology
- Melanoma
- genetics
- immunology
- pathology
- therapy
- Neoplasm Metastasis
- genetics
- pathology
- Phenotype
- Prognosis
- Programmed Cell Death 1 Receptor
- antagonists & inhibitors
- Proteomics
- RNA-Seq
- Receptors
- CXCR5
- metabolism
- Single-Cell Analysis
- Survival Rate
- T Cell Transcription Factor 1
- metabolism
- T-Lymphocytes
- immunology
- metabolism
- Tertiary Lymphoid Structures
- genetics
- immunology
- Treatment Outcome
- Tumor Microenvironment
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Cabrita, Rita
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Lauss, Martin
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Sanna, Adriana
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Donia, Marco
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Skaarup Larsen, ...
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Mitra, Shamik
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show more...
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Johansson, Iva
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Phung, Bengt
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Harbst, Katja
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Vallon-Christers ...
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van Schoiack, Al ...
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Lövgren, Kristin ...
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Warren, Sarah
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Jirström, Karin
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Olsson, Håkan
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Pietras, Kristia ...
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Ingvar, Christia ...
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Isaksson, Karoli ...
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Schadendorf, Dir ...
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Schmidt, Henrik
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Bastholt, Lars
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Carneiro, Ana
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Wargo, Jennifer ...
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Svane, Inge Mari ...
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Jönsson, Göran
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature
- By the university
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University of Gothenburg
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Lund University