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  • Tate, A. E.Karolinska Institutet (författare)

A genetically informed prediction model for suicidal and aggressive behaviour in teens

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-11-21
  • Springer Science and Business Media LLC,2022

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/321767
  • https://gup.ub.gu.se/publication/321767URI
  • https://doi.org/10.1038/s41398-022-02245-wDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102428URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-322362URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151209833URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20221212
  • Suicidal and aggressive behaviours cause significant personal and societal burden. As risk factors associated with these behaviours frequently overlap, combined approaches in predicting the behaviours may be useful in identifying those at risk for either. The current study aimed to create a model that predicted if individuals will exhibit suicidal behaviour, aggressive behaviour, both, or neither in late adolescence. A sample of 5,974 twins from the Child and Adolescent Twin Study in Sweden (CATSS) was broken down into a training (80%), tune (10%) and test (10%) set. The Netherlands Twin Register (NTR; N = 2702) was used for external validation. Our longitudinal data featured genetic, environmental, and psychosocial predictors derived from parental and self-report data. A stacked ensemble model was created which contained a gradient boosted machine, random forest, elastic net, and neural network. Model performance was transferable between CATSS and NTR (macro area under the receiver operating characteristic curve (AUC) [95% CI] AUC(CATSS(test set)) = 0.709 (0.671-0.747); AUC(NTR) = 0.685 (0.656-0.715), suggesting model generalisability across Northern Europe. The notable exception is suicidal behaviours in the NTR, which was no better than chance. The 25 highest scoring variable importance scores for the gradient boosted machines and random forest models included self-reported psychiatric symptoms in mid-adolescence, sex, and polygenic scores for psychiatric traits. The model's performance is comparable to current prediction models that use clinical interviews and is not yet suitable for clinical use. Moreover, genetic variables may have a role to play in predictive models of adolescent psychopathology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Akingbuwa, W. A.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands,Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.;Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands. (författare)
  • Karlsson, R.Karolinska Institutet (författare)
  • Hottenga, J. J.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands,Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands. (författare)
  • Pool, R.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands,Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.;Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands. (författare)
  • Boman, MagnusKarolinska Institutet,KTH,Programvaruteknik och datorsystem, SCS,Karolinska Inst, Dept Learning Informat Management & Eth, Solna, Sweden.(Swepub:kth)u1tnstr8 (författare)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.;Örebro Univ, Sch Med Sci, Örebro, Sweden.(Swepub:oru)hiln (författare)
  • Lundström, SebastianGothenburg University,Göteborgs universitet,Gillbergcentrum,Centrum för etik, juridik och mental hälsa,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law, and Mental Health,Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden; Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, Gothenburg, Sweden.;Univ Gothenburg, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.(Swepub:gu)xluseb (författare)
  • Lichtenstein, P.Karolinska Institutet (författare)
  • Middeldorp, C. M.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Child Health Research Centre, the University of Queensland, Brisbane, QLD, Australia; Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Services, Brisbane, QLD, Australia,Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.;Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld, Australia.;Childrens Hlth Queensland Hosp & Hlth Serv, Child & Youth Mental Hlth Serv, Brisbane, Qld, Australia. (författare)
  • Bartels, M.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands,Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands. (författare)
  • Kuja-Halkola, R.Karolinska Institutet (författare)
  • Karolinska InstitutetDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Translational Psychiatry: Springer Science and Business Media LLC12:12158-3188

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