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Long-Term Outcomes After Atrial Switch Operation for Transposition of the Great Arteries

Broberg, C. S. (author)
van Dissel, A. (author)
Minnier, J. (author)
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Aboulhosn, J. (author)
Kauling, R. M. (author)
Ginde, S. (author)
Krieger, E. V. (author)
Rodriguez, III (author)
Gupta, T. (author)
Shah, S. (author)
John, A. S. (author)
Cotts, T. (author)
Kay, W. A. (author)
Kuo, M. (author)
Dwight, C. (author)
Woods, P. (author)
Nicolarsen, J. (author)
Sarubbi, B. (author)
Fusco, F. (author)
Antonova, P. (author)
Fernandes, S. (author)
Grewal, J. (author)
Cramer, J. (author)
Khairy, P. (author)
Gallego, P. (author)
O'Donnell, C. (author)
Hannah, J. (author)
Dellborg, Mikael, 1954 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Rodriguez-Monserrate, C. P. (author)
Muhll, I. V. (author)
Pylypchuk, S. (author)
Magalski, A. (author)
Han, F. (author)
Lubert, A. M. (author)
Kay, J. (author)
Yeung, E. (author)
Roos-Hesselink, J. (author)
Baker, D. (author)
Celermajer, D. S. (author)
Burchill, L. J. (author)
Wilson, W. M. (author)
Wong, J. (author)
Kutty, S. (author)
Opotowsky, A. R. (author)
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 (creator_code:org_t)
Elsevier BV, 2022
2022
English.
In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 80:10, s. 951-963
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: For patients with d-loop transposition of the great arteries (d-TGA) with a systemic right ventricle after an atrial switch operation, there is a need to identify risks for end-stage heart failure outcomes. Objectives: The authors aimed to determine factors associated with survival in a large cohort of such individuals. Methods: This multicenter, retrospective cohort study included adults with d-TGA and prior atrial switch surgery seen at a congenital heart center. Clinical data from initial and most recent visits were obtained. The composite primary outcome was death, transplantation, or mechanical circulatory support (MCS). Results: From 1,168 patients (38% female, age at first visit 29 ± 7.2 years) during a median 9.2 years of follow-up, 91 (8.8% per 10 person-years) met the outcome (66 deaths, 19 transplantations, 6 MCS). Patients experiencing sudden/arrhythmic death were younger than those dying of other causes (32.6 ± 6.4 years vs 42.4 ± 6.8 years; P < 0.001). There was a long duration between sentinel clinical events and end-stage heart failure. Age, atrial arrhythmia, pacemaker, biventricular enlargement, systolic dysfunction, and tricuspid regurgitation were all associated with the primary outcome. Independent 5-year predictors of primary outcome were prior ventricular arrhythmia, heart failure admission, complex anatomy, QRS duration >120 ms, and severe right ventricle dysfunction based on echocardiography. Conclusions: For most adults with d-TGA after atrial switch, progress to end-stage heart failure or death is slow. A simplified prediction score for 5-year adverse outcome is derived to help identify those at greatest risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

atrial arrhythmia
congenital heart disease
congestive heart failure
QRS duration
systemic right ventricle
transposition of the great arteries

Publication and Content Type

ref (subject category)
art (subject category)

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