Liver-on-a-chip devices: the pros and cons of complexity

Dalsbecker, Philip,1991Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU) (författare)

Physiologically relevant and broadly applicable liver cell culture platforms are of great importance in both drug development and disease modeling. Organ-on-a-chip systems offer a promising alternative to conventional, static two-dimensional (2-D) cultures, providing much-needed cues such as perfusion, shear stress, and three-dimensional (3-D) cell-cell communication. However, such devices cover a broad range of complexity both in manufacture and in implementation. In this review, we summarize the key features of the human liver that should be reflected in a physiologically relevant liver-on-a-chip model. We also discuss different material properties of importance in producing liver-on-a-chip devices and summarize recent and current progress in the field, highlighting different types of devices at different levels of complexity.

Adiels, Caroline B.,1976Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xbecca (författare)
Goksör, Mattias,1975Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xgokma (författare)
Göteborgs universitetInstitutionen för fysik (GU) (creator_code:org_t)

Ingår i:American journal of physiology. Gastrointestinal and liver physiology: American Physiological Society323:31522-15470193-1857

Av författaren/redakt...: Dalsbecker, Phil ...; Adiels, Caroline ...; Goksör, Mattias, ...

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