Sökning: WFRF:(Bódizs Szabolcs 1996) >
Structural mechanis...
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Wahlgren, Weixiao Yuan,1970Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.
(författare)
Structural mechanism of signal transduction in a phytochrome histidine kinase
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-12-12
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Springer Science and Business Media LLC,2022
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/322124
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https://gup.ub.gu.se/publication/322124URI
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https://doi.org/10.1038/s41467-022-34893-3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-501959URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Phytochrome proteins detect red/far-red light to guide the growth, motion, development and reproduction in plants, fungi, and bacteria. Bacterial phytochromes commonly function as an entrance signal in two-component sensory systems. Despite the availability of three-dimensional structures of phytochromes and other two-component proteins, the conformational changes, which lead to activation of the protein, are not understood. We reveal cryo electron microscopy structures of the complete phytochrome from Deinoccocus radiodurans in its resting and photoactivated states at 3.6 Å and 3.5 Å resolution, respectively. Upon photoactivation, the photosensory core module hardly changes its tertiary domain arrangement, but the connector helices between the photosensory and the histidine kinase modules open up like a zipper, causing asymmetry and disorder in the effector domains. The structures provide a framework for atom-scale understanding of signaling in phytochromes, visualize allosteric communication over several nanometers, and suggest that disorder in the dimeric arrangement of the effector domains is important for phosphatase activity in a two-component system. The results have implications for the development of optogenetic applications.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Claesson, Elin,1989Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.(Swepub:gu)xclael
(författare)
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Tuure, IidaUniv Jyvaskyla, Nanosci Ctr, Dept Biol & Environm Sci, Jyvaskyla, Finland.
(författare)
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Trillo-Muyo, Sergio,1983Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Univ Gothenburg, Dept Med Biochem & Cell Biol, Gothenburg, Sweden.(Swepub:gu)xtrise
(författare)
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Bódizs, Szabolcs,1996Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.(Swepub:gu)xbodsz
(författare)
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Ihalainen, Janne A.Univ Jyvaskyla, Nanosci Ctr, Dept Biol & Environm Sci, Jyvaskyla, Finland.
(författare)
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Takala, HeikkiUniv Jyvaskyla, Nanosci Ctr, Dept Biol & Environm Sci, Jyvaskyla, Finland.;Univ Helsinki, Fac Med, Anat, Helsinki, Finland.
(författare)
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Westenhoff, Sebastian,1978Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Biokemi,Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden(Swepub:uu)sebwe861
(författare)
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Göteborgs universitetInstitutionen för kemi och molekylärbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Communications: Springer Science and Business Media LLC132041-1723
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