Stroke genetics informs drug discovery and risk prediction across ancestries

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MARC

Mishra, A.University of Bordeaux (author)

Stroke genetics informs drug discovery and risk prediction across ancestries

Article/chapterEnglish2022

Publisher, publication year, extent ...

2022-09-30
Springer Science and Business Media LLC,2022

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/322231
https://gup.ub.gu.se/publication/322231URI
https://doi.org/10.1038/s41586-022-05165-3DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200734URI
https://lup.lub.lu.se/record/5e54bbd2-c610-458b-81bb-15f6b27f8a9eURI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150831010URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Publisher correction: Mishra, A., Malik, R., Hachiya, T. et al. Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries. Nature 612, E7 (2022). DOI: 10.1038/s41586-022-05492-5
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

Subject headings and genre

NATURVETENSKAP Matematik Sannolikhetsteori och statistik hsv//swe
NATURAL SCIENCES Mathematics Probability Theory and Statistics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
genome-wide association
mendelian randomization
polygenic risk
heritability
statistics
expression
brain
atlas
regularization
metaanalysis
Science & Technology - Other Topics

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Malik, R. (author)
Hachiya, T. (author)
Jurgenson, T. (author)
Namba, S. (author)
Posner, D. C. (author)
Kamanu, F. K. (author)
Koido, M.Karolinska Institutet (author)
Le Grand, Q. (author)
Shi, M. Y. (author)
He, Y. Y. (author)
Georgakis, M. K. (author)
Caro, I. (author)
Krebs, K. (author)
Liaw, Y. C. (author)
Vaura, F. C. (author)
Lin, K. (author)
Winsvold, B. S. (author)
Srinivasasainagendra, V. (author)
Parodi, L. (author)
Bae, H. J. (author)
Chauhan, G. (author)
Chong, M. C. R. (author)
Tomppo, L. (author)
Akinyemi, R. (author)
Roshchupkin, G. V. (author)
Habib, N. (author)
Jee, Y. H. (author)
Thomassen, J. Q. (author)
Abedi, V. (author)
Carcel-Marquez, J. (author)
Nygaard, M. (author)
Leonard, H. L. (author)
Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjerch (author)
Yonova-Doing, E. (author)
Knol, M. J. (author)
Lewis, A. J. (author)
Judy, R. L.Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine (author)
Ago, T. (author)
Amouyel, P. (author)
Armstrong, N. D. (author)
Bakker, M. K. (author)
Bartz, T. M. (author)
Bennett, D. A. (author)
Bis, J. C. (author)
Bordes, C. (author)
Borte, S. (author)
Cain, A. (author)
Ridker, P. M. (author)
Cho, K. (author)
Chen, Z. M. (author)
Cruchaga, C. (author)
Cole, J. W. (author)
de Jager, P. L. (author)
de Cid, R. (author)
Endres, M. (author)
Ferreira, L. E. (author)
Geerlings, M. I. (author)
Gasca, N. C. (author)
Gudnason, V. (author)
Hata, J. (author)
He, J. (author)
Heath, A. K. (author)
Ho, Y. L. (author)
Havulinna, A. S. (author)
Hopewell, J. C. (author)
Hyacinth, H. I. (author)
Inouye, M. (author)
Jacob, M. A. (author)
Jeon, C. E. (author)
Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjerch (author)
Kamouchi, M. (author)
Keene, K. L. (author)
Kitazono, T. (author)
Kittner, S. J. (author)
Konuma, T. (author)
Kumar, A. (author)
Lacaze, P.Karolinska Institutet (author)
Launer, L. J. (author)
Lee, K. J. (author)
Lepik, K. (author)
Li, J. (author)
Li, L. M. (author)
Manichaikul, A. (author)
Markus, H. S. (author)
Marston, N. A. (author)
Meitinger, T. (author)
Mitchell, B. D. (author)
Montellano, F. A. (author)
Morisaki, T. (author)
Mosley, T. H. (author)
Nalls, M. A. (author)
Nordestgaard, B. G. (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Okada, Y. (author)
Onland-Moret, N. C. (author)
Ovbiagele, B. (author)
Peters, A. (author)
Psaty, B. M. (author)
Rich, S. S. (author)
Rosand, J. (author)
Sabatine, M. S. (author)
Sacco, R. L. (author)
Saleheen, D. (author)
Sandset, E. C. (author)
Salomaa, V. (author)
Sargurupremraj, M. (author)
Sasaki, M. (author)
Satizabal, C. L. (author)
Schmidt, C. O. (author)
Shimizu, A. (author)
Smith, N. L. (author)
Sloane, K. L. (author)
Sutoh, Y. (author)
Sun, Y. V. (author)
Tanno, K. (author)
Tiedt, S. (author)
Tatlisumak, T. (author)
Torres-Aguila, N. P. (author)
Tiwari, H. K. (author)
Tregouet, D. A. (author)
Trompet, S. (author)
Tuladhar, A. M. (author)
Tybjaerg-Hansen, A. (author)
van Vugt, M. (author)
Vibo, R. (author)
Verma, S. S. (author)
Wiggins, K. L. (author)
Wennberg, Patrik,1972-Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002 (author)
Woo, D. (author)
Wilson, P. W. F. (author)
Xu, H. C. (author)
Yang, Q. (author)
Yoon, K. (author)
Bis, J. C. (author)
Bis, J. C. (author)
Lee, J. M. (author)
Cheng, Y. C. (author)
Meschia, J. F. (author)
Chen, W. M. (author)
Sale, M. M. (author)
Zonderman, A. B. (author)
Evans, M. K. (author)
Wilson, J. G. (author)
Correa, A. (author)
Traylor, M. (author)
Lewis, C. M. (author)
Carty, C. L. (author)
Reiner, A. (author)
Haessler, J. (author)
Langefeld, C. D. (author)
Gottesman, R. F. (author)
Yaffe, K. (author)
Liu, Y. M. (author)
Kooperberg, C. (author)
Lange, L. A. (author)
Furie, K. L. (author)
Arnett, D. K. (author)
Benavente, O. R. (author)
Grewal, R. P. (author)
Peddareddygari, L. R. (author)
Kooperberg, C. (author)
Kooperberg, C. (author)
Hveem, K. (author)
Lindstrom, S. (author)
Wang, L. (author)
Smith, E. N. (author)
Gordon, W. (author)
Vlieg, A. V. (author)
de Andrade, M. (author)
Brody, J. A. (author)
Pattee, J. W. (author)
Haessler, J. (author)
Brumpton, B. M. (author)
Suchon, P. (author)
Chen, M. H. (author)
Frazer, K. A. (author)
Turman, C. (author)
Germain, M. (author)
MacDonald, J. (author)
Braekkan, S. K. (author)
Armasu, S. M. (author)
Pankratz, N. (author)
Jackson, R. D. (author)
Nielsen, J. B. (author)
Giulianini, F. (author)
Puurunen, M. K. (author)
Ibrahim, M. (author)
Heckbert, S. R. (author)
Bammler, T. K. (author)
McCauley, B. M. (author)
Taylor, K. D. (author)
Pankow, J. S. (author)
Reiner, A. P. (author)
Gabrielsen, M. E. (author)
Deleuze, J. F. (author)
O'Donnell, C. J. (author)
Kim, J. (author)
McKnight, B. (author)
Kraft, P. (author)
Hansen, J. B. (author)
Rosendaal, F. R. (author)
Heit, J. A. (author)
Tang, W. H. (author)
Morange, P. E. (author)
Johnson, A. D. (author)
Kabrhel, C. (author)
van Dijk, E. J. (author)
van Dijk, E. J. (author)
Koudstaal, P. J.Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine (author)
Luijckx, G. J. (author)
Nederkoorn, P. J. (author)
van Oostenbrugge, R. J. (author)
Visser, M. C. (author)
Wermer, M. J. H. (author)
Kappelle, L. J. (author)
Esko, T. (author)
Esko, T. (author)
Metspalu, A. (author)
Magi, R. (author)
Nelis, M. (author)
Irvin, M. R. (author)
Irvin, M. R. (author)
de Leeuw, F. E. (author)
Levi, C. R. (author)
Maguire, J. (author)
Jimenez-Conde, J. (author)
Sharma, P. (author)
Sudlow, C. L. M. (author)
Rannikmae, K. (author)
Schmidt, R. (author)
Slowik, A. (author)
Pera, J. (author)
Thijs, V. N. S. (author)
Lindgren, A. G. (author)
Ilinca, A. (author)
Melander, O. (author)
Engstrom, G. (author)
Rexrode, K. M. (author)
Rothwell, P. M. (author)
Stanne, T. M. (author)
Johnson, J. A. (author)
Danesh, J. (author)
Butterworth, A. S. (author)
Heitsch, L. (author)
Boncoraglio, G. B. (author)
Kubo, M. (author)
Pezzini, A. (author)
Rolfs, A. (author)
Giese, A. K. (author)
Weir, D. (author)
Jackson, R. D. (author)
Ross, O. A. (author)
Lemmons, R. (author)
Soderholm, M. (author)
Cushman, M. (author)
Jood, K. (author)
McDonough, C. W. (author)
Bell, S. (author)
Linkohr, B. (author)
Lee, T. H. (author)
Putaala, JukkaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine (author)
Anderson, C. D. (author)
Anderson, C. D. (author)
Lopez, O. L. (author)
Jian, X. Q. (author)
Schminke, U. (author)
Cullell, N. (author)
Delgado, P. (author)
Ibanez, L. (author)
Krupinski, J. (author)
Lioutas, V. (author)
Matsuda, K. (author)
Montaner, J. (author)
Muino, E. (author)
Roquer, J. (author)
Sarnowski, C. (author)
Sattar, N. (author)
Sibolt, G. (author)
Teumer, A. (author)
Rutten-Jacobs, L. (author)
Kanai, M. (author)
Giese, A. K. (author)
Gretarsdottir, S. (author)
Rost, N. S. (author)
Yusuf, S. (author)
Almgren, P. (author)
Ay, H. (author)
Bevan, S. (author)
Brown, R. D. (author)
Carrera, C. (author)
Buring, J. E. (author)
Chen, W. M. (author)
Cotlarciuc, I. (author)
de Bakker, P. I. W. (author)
DeStefano, A. L. (author)
den Hoed, M. (author)
Duan, Q. (author)
Engelter, S. T. (author)
Falcone, G. J. (author)
Gottesman, R. F. (author)
Gustafsson, S. (author)
Hassan, A. (author)
Holliday, E. G. (author)
Howard, G. (author)
Hsu, F. C. (author)
Ingelsson, E. (author)
Harris, T. B. (author)
Kissela, B. M. (author)
Kleindorfer, D. O. (author)
Langenberg, C. (author)
Lemmens, RobinGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine (author)
Leys, D. (author)
Lin, W. Y. (author)
Lorentzen, E. (author)
Magnusson, P. K. (author)
McArdle, P. F. (author)
Pulit, S. L. (author)
Rice, K. (author)
Sakaue, S. (author)
Sapkota, B. R. (author)
Tanislav, C. (author)
Thorleifsson, G. (author)
Thorsteinsdottir, U. (author)
Tzourio, C. (author)
van Duijn, C. M. (author)
Walters, M. (author)
Wareham, N. J. (author)
Amin, N. (author)
Aparicio, H. J. (author)
Attia, J. (author)
Beiser, A. S. (author)
Berr, C. (author)
Bustamante, M. (author)
Caso, V. (author)
Choi, S. H. (author)
Chowhan, A. (author)
Dartigues, J. F. (author)
Delavaran, H. (author)
Dorr, M. (author)
Ford, I. (author)
Gurpreet, W. S. (author)
Hamsten, A. (author)
Hozawa, A. (author)
Ingelsson, M. (author)
Iwasaki, M. (author)
Kaffashian, S. (author)
Kalra, L. (author)
Kjartansson, O. (author)
Kloss, M. (author)
Labovitz, D. L. (author)
Laurie, C. C. (author)
Li, L. N. (author)
Lind, L. (author)
Lindgren, C. M. (author)
Makoto, H. (author)
Minegishi, N. (author)
Morris, A. P. (author)
Muller-Nurasyid, M. (author)
Norrving, B. (author)
Ogishima, S. (author)
Parati, E. A. (author)
Pedersen, N. L. (author)
Perola, M. (author)
Jousilahti, P. (author)
Pileggi, S. (author)
Rabionet, R. (author)
Riba-Llena, I. (author)
Ribases, M. (author)
Romero, J. R. (author)
Rudd, A. G. (author)
Sarin, A. P. (author)
Sarju, R. (author)
Satoh, M. (author)
Sawada, N. (author)
Sigurdsson, A. (author)
Smith, A. (author)
Stine, O. C. (author)
Stott, D. J. (author)
Strauch, K. (author)
Takai, T. (author)
Tanaka, H. (author)
Touze, E. (author)
Tsugane, S. (author)
Uitterlinden, A. G. (author)
Valdimarsson, E. M. (author)
van der Lee, S. J. (author)
Wakai, K. (author)
Williams, S. R. (author)
Wolfe, C. D. A. (author)
Wong, Q. N. (author)
Yamaji, T. (author)
Sanghera, D. K. (author)
Stefansson, K. (author)
Taylor, K. D. (author)
Martinez-Majander, N. (author)
Sobue, K. (author)
Soriano-Tarraga, C. (author)
Volzke, H. (author)
Akpa, O. (author)
Akpa, O. (author)
Sarfo, F. S. (author)
Akpalu, A. (author)
Obiako, R. (author)
Wahab, K. (author)
Osaigbovo, G. (author)
Owolabi, L. (author)
Komolafe, M. (author)
Jenkins, C. (author)
Arulogun, O. (author)
Ogbole, G. (author)
Adeoye, A. M. (author)
Akinyemi, J. (author)
Agunloye, A. (author)
Fakunle, A. G. (author)
Uvere, E. (author)
Olalere, A. (author)
Adebajo, O. J. (author)
Chen, J. S. (author)
Chen, J. S. (author)
Clarke, R. (author)
Collins, R. (author)
Guo, Y. (author)
Wang, C. (author)
Lv, J. (author)
Peto, R. (author)
Chen, Y. P. (author)
Fairhurst-Hunter, Z. (author)
Hill, M. (author)
Pozarickij, A. (author)
Schmidt, D. (author)
Stevens, B. (author)
Turnbull, I. (author)
Yu, C. Q. (author)
Le Grand, Q. (author)
Le Grand, Q. (author)
Ferreira, L. E. (author)
Nagai, A. (author)
Nagai, A. (author)
Murakami, Y. (author)
Geerlings, M. I. (author)
Geerlings, M. I. (author)
Gasca, N. C. (author)
Gudnason, V. (author)
van Vugt, M. (author)
Gottesman, R. F. (author)
Shiroma, E. J. (author)
Sigurdsson, S. (author)
Ghanbari, M. (author)
Boerwinkle, E. (author)
Beiser, A. S. (author)
Fongang, B. (author)
Wang, R. Q. (author)
Ikram, M. K. (author)
Volker, U. (author)
de Jager, P. L. (author)
de Jager, P. L. (author)
de Cid, R. (author)
Nordestgaard, B. G. (author)
Sargurupremraj, M. (author)
Verma, S. S. (author)
de Laat, K. F. (author)
de Laat, K. F. (author)
van Norden, A. G. W. (author)
de Kort, P. L. (author)
Vermeer, S. E. (author)
Brouwers, Pjam (author)
Gons, R. A. R. (author)
Nederkoorn, P. J. (author)
den Heijer, T. (author)
van Dijk, G. W. (author)
van Rooij, F. G. W. (author)
Aamodt, A. H. (author)
Aamodt, A. H. (author)
Skogholt, A. H. (author)
Brumpton, B. M. (author)
Willer, C. J. (author)
Heuch, I. (author)
Hagen, K. (author)
Fritsche, L. G. (author)
Pedersen, L. M. (author)
Gabrielsen, M. E. (author)
Ellekjaer, H. (author)
Zhou, W. (author)
Martinsen, A. E. (author)
Kristoffersen, E. S. (author)
Nielsen, J. B. (author)
Hveem, K. (author)
Thomas, L. F. (author)
Kleinschnitz, C. (author)
Kleinschnitz, C. (author)
Frantz, S. (author)
Ungethum, K. (author)
Gallego-Fabrega, C. (author)
Gallego-Fabrega, C. (author)
Lledos, M. (author)
Llucia-Carol, L. (author)
Sobrino, T. (author)
Campos, F. (author)
Castillo, J. (author)
Freijo, M. (author)
Arenillas, J. F. (author)
Obach, V. (author)
Alvarez-Sabin, J. (author)
Molina, C. A. (author)
Ribo, M. (author)
Munoz-Narbona, L. (author)
Lopez-Cancio, E. (author)
Millan, M. (author)
Diaz-Navarro, R. (author)
Vives-Bauza, C. (author)
Serrano-Heras, G. (author)
Segura, T. (author)
Delgado, P. (author)
Dhar, R. (author)
Delgado-Mederos, R. (author)
Prats-Sanchez, L. (author)
Camps-Renom, P. (author)
Blay, N. (author)
Sumoy, L. (author)
Marti-Fabregas, J. (author)
Schnohr, P. (author)
Schnohr, P. (author)
Jensen, G. B. (author)
Benn, M. (author)
Afzal, S. (author)
Kamstrup, P. R. (author)
van Setten, J. (author)
van Setten, J. (author)
van der Laan, S. W. (author)
Vonk, J. M. J. (author)
Kim, B. J. (author)
Kim, B. J. (author)
Curtze, S. (author)
Curtze, S. (author)
Tiainen, M. (author)
Kinnunen, J. (author)
Menon, V. (author)
Menon, V. (author)
Sung, Y. J. (author)
Yang, C. R. (author)
Saillour-Glenisson, F. (author)
Gravel, S. (author)
Onland-Moret, N. C. (author)
Onland-Moret, N. C. (author)
Heath, A. K. (author)
Millwood, I. Y. (author)
Gieger, C. (author)
Ninomiya, T. (author)
Grabe, H. J. (author)
Jukema, J. W. (author)
Rissanen, I. L. (author)
Strbian, D. (author)
Kim, Y. J. (author)
Chen, P. H. (author)
Mayerhofer, E. (author)
Howson, J. M. M. (author)
Irvin, M. R. (author)
Adams, H. (author)
Wassertheil-Smoller, S. (author)
Christensen, K. (author)
Ikram, M. A. (author)
Rundek, T. (author)
Worrall, B. B. (author)
Lathrop, G. M. (author)
Riaz, M. (author)
Simonsick, E. M. (author)
Korv, J. (author)
Franca, P. H. C. (author)
Zand, R. (author)
Prasad, K. (author)
Frikke-Schmidt, R. (author)
de Leeuw, F. E. (author)
Liman, T. (author)
Haeusler, K. G. (author)
Ruigrok, Y. M. (author)
Heuschmann, P. U. (author)
Longstreth, W. T. (author)
Jung, K. J. (author)
Bastarache, L. (author)
Pare, G. (author)
Damrauer, S. M. (author)
Chasman, D. I. (author)
Rotter, J. I. (author)
Anderson, C. D. (author)
Zwart, J. A. (author)
Niiranen, T. J. (author)
Fornage, M. (author)
Liaw, Y. P. (author)
Seshadri, S. (author)
Fernandez-Cadenas, I. (author)
Walters, R. G. (author)
Ruff, C. T. (author)
Owolabi, M. O. (author)
Huffman, J. E. (author)
Milani, L. (author)
Kamatani, Y. (author)
Dichgans, M. (author)
Debette, S.University of Bordeaux (author)
Compass Consortium, Compass Consortium (author)
Invent Consortium, Invent Consortium (author)
Estonian, Biobank (author)
Preciseq Consortium, Preciseq Consortium (author)
FinnGen, Consortium (author)
Megastroke Consortium, Megastroke Consortium (author)
Siren Consortium, Siren Consortium (author)
Biobank, Japan (author)
Charge Consortium, Charge Consortium (author)
Gigastroke Consortium, Gigastroke Consortium (author)
Regeneron Genetics, Ctr (author)
Odyssey Study, Odyssey Study (author)
Sicfail Study, Sicfail Study (author)
Generacion, Study (author)
Smart Study, Smart Study (author)
Helsinki Stroke, Project (author)
Epic,, Epic, (author)
Karolinska InstitutetUniversity of Bordeaux (creator_code:org_t)

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By the author/editor: Mishra, A.; Malik, R.; Hachiya, T.; Jurgenson, T.; Namba, S.; Posner, D. C.; show more...; Kamanu, F. K.; Koido, M.; Le Grand, Q.; Shi, M. Y.; He, Y. Y.; Georgakis, M. K.; Caro, I.; Krebs, K.; Liaw, Y. C.; Vaura, F. C.; Lin, K.; Winsvold, B. S.; Srinivasasainage ...; Parodi, L.; Bae, H. J.; Chauhan, G.; Chong, M. C. R.; Tomppo, L.; Akinyemi, R.; Roshchupkin, G. ...; Habib, N.; Jee, Y. H.; Thomassen, J. Q.; Abedi, V.; Carcel-Marquez, ...; Nygaard, M.; Leonard, H. L.; Jern, Christina, ...; Yonova-Doing, E.; Knol, M. J.; Lewis, A. J.; Judy, R. L.; Ago, T.; Amouyel, P.; Armstrong, N. D.; Bakker, M. K.; Bartz, T. M.; Bennett, D. A.; Bis, J. C.; Bordes, C.; Borte, S.; Cain, A.; Ridker, P. M.; Cho, K.; Chen, Z. M.; Cruchaga, C.; Cole, J. W.; de Jager, P. L.; de Cid, R.; Endres, M.; Ferreira, L. E.; Geerlings, M. I.; Gasca, N. C.; Gudnason, V.; Hata, J.; He, J.; Heath, A. K.; Ho, Y. L.; Havulinna, A. S.; Hopewell, J. C.; Hyacinth, H. I.; Inouye, M.; Jacob, M. A.; Jeon, C. E.; Kamouchi, M.; Keene, K. L.; Kitazono, T.; Kittner, S. J.; Konuma, T.; Kumar, A.; Lacaze, P.; Launer, L. J.; Lee, K. J.; Lepik, K.; Li, J.; Li, L. M.; Manichaikul, A.; Markus, H. S.; Marston, N. A.; Meitinger, T.; Mitchell, B. D.; Montellano, F. A ...; Morisaki, T.; Mosley, T. H.; Nalls, M. A.; Nordestgaard, B. ...; Melander, Olle; Okada, Y.; Onland-Moret, N. ...; Ovbiagele, B.; Peters, A.; Psaty, B. M.; Rich, S. S.; Rosand, J.; Sabatine, M. S.; Sacco, R. L.; Saleheen, D.; Sandset, E. C.; Salomaa, V.; Sargurupremraj, ...; Sasaki, M.; Satizabal, C. L.; Schmidt, C. O.; Shimizu, A.; Smith, N. L.; Sloane, K. L.; Sutoh, Y.; Sun, Y. V.; Tanno, K.; Tiedt, S.; Tatlisumak, T.; Torres-Aguila, N ...; Tiwari, H. K.; Tregouet, D. A.; Trompet, S.; Tuladhar, A. M.; Tybjaerg-Hansen, ...; van Vugt, M.; Vibo, R.; Verma, S. S.; Wiggins, K. L.; Wennberg, Patrik ...; Woo, D.; Wilson, P. W. F.; Xu, H. C.; Yang, Q.; Yoon, K.; Lee, J. M.; Cheng, Y. C.; Meschia, J. F.; Chen, W. M.; Sale, M. M.; Zonderman, A. B.; Evans, M. K.; Wilson, J. G.; Correa, A.; Traylor, M.; Lewis, C. M.; Carty, C. L.; Reiner, A.; Haessler, J.; Langefeld, C. D.; Gottesman, R. F.; Yaffe, K.; Liu, Y. M.; Kooperberg, C.; Lange, L. A.; Furie, K. L.; Arnett, D. K.; Benavente, O. R.; Grewal, R. P.; Peddareddygari, ...; Hveem, K.; Lindstrom, S.; Wang, L.; Smith, E. N.; Gordon, W.; Vlieg, A. V.; de Andrade, M.; Brody, J. A.; Pattee, J. W.; Brumpton, B. M.; Suchon, P.; Chen, M. H.; Frazer, K. A.; Turman, C.; Germain, M.; MacDonald, J.; Braekkan, S. K.; Armasu, S. M.; Pankratz, N.; Jackson, R. D.; Nielsen, J. B.; Giulianini, F.; Puurunen, M. K.; Ibrahim, M.; Heckbert, S. R.; Bammler, T. K.; McCauley, B. M.; Taylor, K. D.; Pankow, J. S.; Reiner, A. P.; Gabrielsen, M. E ...; Deleuze, J. F.; O'Donnell, C. J.; Kim, J.; McKnight, B.; Kraft, P.; Hansen, J. B.; Rosendaal, F. R.; Heit, J. A.; Tang, W. H.; Morange, P. E.; Johnson, A. D.; Kabrhel, C.; van Dijk, E. J.; Koudstaal, P. J.; Luijckx, G. J.; Nederkoorn, P. 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P.; Fairhurst-Hunter ...; Hill, M.; Pozarickij, A.; Schmidt, D.; Stevens, B.; Turnbull, I.; Yu, C. Q.; Nagai, A.; Murakami, Y.; Shiroma, E. J.; Sigurdsson, S.; Ghanbari, M.; Boerwinkle, E.; Fongang, B.; Wang, R. Q.; Ikram, M. K.; Volker, U.; de Laat, K. F.; van Norden, A. G ...; de Kort, P. L.; Vermeer, S. E.; Brouwers, Pjam; Gons, R. A. R.; den Heijer, T.; van Dijk, G. W.; van Rooij, F. G. ...; Aamodt, A. H.; Skogholt, A. H.; Willer, C. J.; Heuch, I.; Hagen, K.; Fritsche, L. G.; Pedersen, L. M.; Ellekjaer, H.; Zhou, W.; Martinsen, A. E.; Kristoffersen, E ...; Thomas, L. F.; Kleinschnitz, C.; Frantz, S.; Ungethum, K.; Gallego-Fabrega, ...; Lledos, M.; Llucia-Carol, L.; Sobrino, T.; Campos, F.; Castillo, J.; Freijo, M.; Arenillas, J. F.; Obach, V.; Alvarez-Sabin, J ...; Molina, C. A.; Ribo, M.; Munoz-Narbona, L ...; Lopez-Cancio, E.; Millan, M.; Diaz-Navarro, R.; Vives-Bauza, C.; Serrano-Heras, G ...; Segura, T.; Dhar, R.; Delgado-Mederos, ...; Prats-Sanchez, L ...; Camps-Renom, P.; Blay, N.; Sumoy, L.; Marti-Fabregas, ...; Schnohr, P.; Jensen, G. B.; Benn, M.; Afzal, S.; Kamstrup, P. R.; van Setten, J.; van der Laan, S. ...; Vonk, J. M. J.; Kim, B. J.; Curtze, S.; Tiainen, M.; Kinnunen, J.; Menon, V.; Sung, Y. J.; Yang, C. R.; Saillour-Gleniss ...; Gravel, S.; Millwood, I. Y.; Gieger, C.; Ninomiya, T.; Grabe, H. J.; Jukema, J. W.; Rissanen, I. L.; Strbian, D.; Kim, Y. J.; Chen, P. H.; Mayerhofer, E.; Howson, J. M. M.; Adams, H.; Wassertheil-Smol ...; Christensen, K.; Ikram, M. A.; Rundek, T.; Worrall, B. B.; Lathrop, G. M.; Riaz, M.; Simonsick, E. M.; Korv, J.; Franca, P. H. C.; Zand, R.; Prasad, K.; Frikke-Schmidt, ...; Liman, T.; Haeusler, K. G.; Ruigrok, Y. M.; Heuschmann, P. U ...; Longstreth, W. T ...; Jung, K. J.; Bastarache, L.; Pare, G.; Damrauer, S. M.; Chasman, D. I.; Rotter, J. I.; Zwart, J. A.; Niiranen, T. J.; Fornage, M.; Liaw, Y. P.; Seshadri, S.; Fernandez-Cadena ...; Walters, R. G.; Ruff, C. T.; Owolabi, M. O.; Huffman, J. E.; Milani, L.; Kamatani, Y.; Dichgans, M.; Debette, S.; Compass Consorti ...; Invent Consortiu ...; Estonian, Bioban ...; Preciseq Consort ...; FinnGen, Consort ...; Megastroke Conso ...; Siren Consortium ...; Biobank, Japan; Charge Consortiu ...; Gigastroke Conso ...; Regeneron Geneti ...; Odyssey Study, O ...; Sicfail Study, S ...; Generacion, Stud ...; Smart Study, Sma ...; Helsinki Stroke, ...; Epic,, Epic; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Mathematics; and Probability Theo ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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