Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma

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Bermúdez Barón, NicolásUmeå universitet,Avdelningen för hållbar hälsa (author)

Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma

Article/chapterEnglish2022

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2022-08-04
European Respiratory Society (ERS),2022

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LIBRIS-ID:oai:gup.ub.gu.se/322267
https://gup.ub.gu.se/publication/322267URI
https://doi.org/10.1183/23120541.00110-2022DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200826URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background With increasing prevalence of overweight and obesity, it is important to study how body mass index (BMI) change may affect lung function among subjects with asthma. There are few prospective studies on this topic, especially with separate analyses of those with normal and high BMI. The aim of the present study was to prospectively study the association between annual BMI change and annual lung function decline, separately among those with normal initial BMI and overweight/obesity, in an adult asthma cohort. Methods A population-based adult asthma cohort was examined at study entry between 1986 and 2001 and at follow-up between 2012 and 2014 (n=945). Annual BMI change was analysed in association with annual decline in forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC separately in those with normal weight (BMI 18.5-24.9) and overweight/obese subjects (BMI >= 25) at study entry. Regression models were used to adjust for sex, age, smoking, inhaled corticosteroids use and occupational exposure to gas, dust or fumes. Results Overweight/obese subjects had lower FEV1 and FVC but slower annual FEV1 and FVC decline compared to those with normal weight. After adjustment through regression modelling, the association between BMI change with FEV1 and FVC decline remained significant for both BMI groups, but with stronger associations among the overweight/obese (FEV1 B-[Overweight/obese]=-25 mL versus B[ normal weight]= -15 mL). However, when including only those with BMI increase during follow-up, the associations remained significant among those with overweight/obesity, but not in the normal-weight group. No associations were seen for FEV1/FVC. Conclusions BMI increase is associated with faster FEV1 and FVC decline among overweight and obese adults with asthma in comparison with their normal-weight counterparts.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
pulmonary-function
cluster-analysis
lung-function
weight-loss
inflammation
smoking
people
Respiratory System

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Kankaanranta, Hannu,1967Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Dept of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Faculty of Medicine and Health Technology, Tampere University, Respiratory Research Group, Tampere University, Tampere, Finland; Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland(Swepub:gu)xkankh (author)
Hedman, Linnea,1979-Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)evli0029 (author)
Andersson, MartinUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)manann00 (author)
Stridsman, CarolineUmeå universitet,Avdelningen för medicin(Swepub:umu)cast0052 (author)
Lindberg, AnneUmeå universitet,Avdelningen för medicin(Swepub:umu)anelig02 (author)
Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)evra0004 (author)
Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)heaban01 (author)
Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

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In:European Respiratory Journal Open Research (ERJ Open Research): European Respiratory Society (ERS)8:42312-0541

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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