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- Munir, S. (författare)
The Association of HLA Alleles and Haplotypes with Age of Disease Onset in Pakistani Psoriatic Patients
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
- 2022-11-16
- S. Karger AG,2023
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/322392
- https://gup.ub.gu.se/publication/322392URI
- https://doi.org/10.1159/000527359DOI
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- Språk:engelska
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- Introduction: The human leukocyte antigen (HLA) region on chromosome 6p21 is well known to carry the most important genetic factors in susceptibility to psoriasis. Different HLA alleles and haplotypes have been reported to be associated with psoriasis in different populations. Psoriasis has a variable age of onset and, based on this, it can be classified into two types; type I with age of onset before 40 years of age and type II with age of onset after 40 years of age. The objective of this study was to determine the association of HLA class I and class II alleles and haplotypes with disease and stratification using age of onset in Pakistani psoriatic patients. Methods: A group of 603 individuals (326 cases and 277 controls) were analyzed for HLA class I and II alleles and haplotype association by sequence specific PCR. The association was further analyzed according to the age of onset of the patients. Results: We found that HLA alleles B*57 and Cw*06:02, DQB1*03:03:02 are strongly associated with early onset psoriasis, while alleles B*15, DRB1*13:02 and DQB1*03:03:02 are associated with late-onset psoriasis. Cw*06:02 allele was not associated with late-onset psoriasis patients. Allele DQB1*03:03:02 had the highest odds ratio in all patients. We found a novel association specifically with late-onset psoriasis samples with the haplotype HLA-A*11; B*15; Cw*04; DRB1*15; DQB1*05 (Pc = 3.60 x 10(-7)). We also found strong association with previously reported extended haplotype EH-57.1: HLA-B*57; Cw*06:02; DRB1*07:01; DQB1*03:03:02 in all our patients (Pc = 8.34 x 10(-07)). Conclusion: Our results show that different HLA class I and II alleles and haplotypes are associated with psoriasis at different age of onset. In this study, we have reported novel alleles and haplotype association with late-onset psoriasis. Our data confirm the previous strong associations with HLA alleles and haplotypes and also reports novel alleles and haplotype association in Pakistani psoriasis patients.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- Psoriasis
- Autoimmunity
- HLA allele
- Haplotype
- major histocompatibility complex
- population
- antigens
- vulgaris
- genetics
- system
- Allergy
- Immunology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Rahman, S. B. (författare)
- Rehman, S. (författare)
- Saba, N. (författare)
- Mazhar, K. (författare)
- Torinsson Naluai, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xnalas (författare)
- Göteborgs universitetInstitutionen för biomedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:International Archives of Allergy and Immunology: S. Karger AG184:2, s. 202-2101018-24381423-0097
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- International Archives of Allergy and Immunology (Sök värdpublikationen i LIBRIS)
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