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Early-Onset Type 2 ...
Early-Onset Type 2 Diabetes and Mood, Anxiety, and Stress-Related Disorders: A Genetically Informative Register-Based Cohort Study.
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- Liu, Shengxin (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Leone, Marica (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Janssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Gudbjörnsdottir, Soffia (författare)
- Swedish National Diabetes Register, Centre of Registers, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Landén, Mikael, 1966 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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- Bergen, Sarah E (författare)
- Karolinska Institutet
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- Taylor, Mark J (författare)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet
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- Butwicka, Agnieszka (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-10-17
- 2022
- Engelska.
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Ingår i: Diabetes care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 45:12, s. 2950-2956
- Relaterad länk:
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https://doi.org/10.2...
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- To assess the association and familial coaggregation between early-onset type 2 diabetes (diagnosed before age 45 years) and mood, anxiety, and stress-related disorders and estimate the contribution of genetic and environmental factors to their co-occurrence.This population-based cohort study included individuals born in Sweden during 1968-1998, from whom pairs of full siblings, half-siblings, and cousins were identified. Information on diagnoses of early-onset type 2 diabetes and mood (including unipolar depression and bipolar disorder), anxiety, and stress-related disorders was obtained from the National Patient Register. Logistic and Cox regression models were used to assess the phenotypic association and familial coaggregation between type 2 diabetes and psychiatric disorders. Quantitative genetic modeling was conducted in full and maternal half-sibling pairs to estimate the relative contributions of genetic and environmental factors to the association.Among a total of 3,061,192 individuals, 7,896 (0.3%) were diagnosed with early-onset type 2 diabetes. These individuals had higher risks of any diagnosis (odds ratio [OR] 3.62 [95% CI 3.44, 3.80]) and specific diagnosis of unipolar depression (3.97 [3.75, 4.22]), bipolar disorder (4.17 [3.68, 4.73]), anxiety (3.76 [3.54, 3.99]), and stress-related disorders (3.35 [3.11, 3.61]). Relatives of individuals with early-onset type 2 diabetes also had higher overall risks of the examined psychiatric disorders (ORs 1.03-1.57). These associations are largely explained by genetic factors (51-78%), with the rest explained by nonshared environmental factors.Our findings highlight the burden of mood, anxiety, and stress-related disorders in early-onset type 2 diabetes and demonstrate that shared familial liability may contribute to their co-occurrence, suggesting that in the future research investigators should aim to identify shared risk factors and ultimately refine preventive and intervention strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Humans
- Middle Aged
- Cohort Studies
- Diabetes Mellitus
- Type 2
- epidemiology
- genetics
- Registries
- Anxiety Disorders
- epidemiology
- genetics
- Risk Factors
- Anxiety
- epidemiology
- genetics
- Sweden
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liu, Shengxin
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Leone, Marica
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Ludvigsson, Jona ...
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Lichtenstein, Pa ...
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Gudbjörnsdottir, ...
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Landén, Mikael, ...
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Bergen, Sarah E
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Taylor, Mark J
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Larsson, Henrik, ...
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Kuja-Halkola, Ra ...
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Butwicka, Agnies ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes care
- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Karolinska Institutet