Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

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Coombes, Brandon J (author)

Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-11-18
S. Karger AG,2021

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LIBRIS-ID:oai:gup.ub.gu.se/322804
https://gup.ub.gu.se/publication/322804URI
https://doi.org/10.1159/000519707DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:236408127URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng

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Millischer, VincentKarolinska Institutet (author)
Batzler, Anthony (author)
Larrabee, Beth (author)
Hou, Liping (author)
Papiol, Sergi (author)
Heilbronner, Urs (author)
Adli, Mazda (author)
Akiyama, Kazufumi (author)
Akula, Nirmala (author)
Amare, Azmeraw T (author)
Ardau, Raffaella (author)
Arias, Barbara (author)
Aubry, Jean-Michel (author)
Backlund, LenaKarolinska Institutet (author)
Bauer, Michael (author)
Baune, Bernhard T (author)
Bellivier, Frank (author)
Benabarre, Antoni (author)
Bengesser, Susanne (author)
Bhattacharjee, Abesh Kumar (author)
Cervantes, Pablo (author)
Chen, Hsi-Chung (author)
Chillotti, CaterinaKarolinska Institutet (author)
Cichon, Sven (author)
Clark, Scott R (author)
Colom, Francesc (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M (author)
Dalkner, Nina (author)
Degenhardt, Franziska (author)
Del Zompo, Maria (author)
DePaulo, J Raymond (author)
Étain, Bruno (author)
Falkai, Peter (author)
Ferensztajn-Rochowiak, Ewa (author)
Forstner, Andreas J (author)
Frisen, LouiseKarolinska Institutet (author)
Gard, Sébastien (author)
Garnham, Julie S (author)
Goes, Fernando S (author)
Grigoroiu-Serbanescu, Maria (author)
Grof, Paul (author)
Hashimoto, Ryota (author)
Hauser, Joanna (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Jamain, Stephane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kato, Tadafumi (author)
Kelsoe, John R (author)
Kittel-Schneider, Sarah (author)
König, Barbara (author)
Kuo, Po-Hsiu (author)
Kusumi, Ichiro (author)
Laje, Gonzalo (author)
Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Maj, MarioKarolinska Institutet (author)
Manchia, Mirko (author)
Martinsson, LinaKarolinska Institutet (author)
McCarthy, Michael J (author)
McElroy, Susan L (author)
Mitchell, Philip B (author)
Mitjans, Marina (author)
Mondimore, Francis M (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline M (author)
Nöthen, Markus M (author)
Novák, Tomas (author)
O'Donovan, Claire (author)
Osby, Urban (author)
Ozaki, Norio (author)
Pfennig, Andrea (author)
Pisanu, Claudia (author)
Potash, James B (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rietschel, Marcella (author)
Rouleau, Guy A (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Schofield, Peter R (author)
Schubert, Klaus Oliver (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D (author)
Shimoda, Katzutaka (author)
Simhandl, Christian (author)
Slaney, Claire M (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Witt, Stephanie H (author)
Zandi, Peter P (author)
Fullerton, Janice M (author)
Alda, Martin (author)
Frye, Mark A (author)
Schulze, Thomas G (author)
McMahon, Francis J (author)
Biernacka, Joanna M (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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In:Complex psychiatry: S. Karger AG7:3-4, s. 80-892673-30052673-298X

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By the author/editor: Coombes, Brandon ...; Millischer, Vinc ...; Batzler, Anthony; Larrabee, Beth; Hou, Liping; Papiol, Sergi; show more...; Heilbronner, Urs; Adli, Mazda; Akiyama, Kazufum ...; Akula, Nirmala; Amare, Azmeraw T; Ardau, Raffaella; Arias, Barbara; Aubry, Jean-Mich ...; Backlund, Lena; Bauer, Michael; Baune, Bernhard ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Bhattacharjee, A ...; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Clark, Scott R; Colom, Francesc; Cruceanu, Cristi ...; Czerski, Piotr M; Dalkner, Nina; Degenhardt, Fran ...; Del Zompo, Maria; DePaulo, J Raymo ...; Étain, Bruno; Falkai, Peter; Ferensztajn-Roch ...; Forstner, Andrea ...; Frisen, Louise; Gard, Sébastien; Garnham, Julie S; Goes, Fernando S; Grigoroiu-Serban ...; Grof, Paul; Hashimoto, Ryota; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Jamain, Stephane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kato, Tadafumi; Kelsoe, John R; Kittel-Schneider ...; König, Barbara; Kuo, Po-Hsiu; Kusumi, Ichiro; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Maj, Mario; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; Mitchell, Philip ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; O'Donovan, Clair ...; Osby, Urban; Ozaki, Norio; Pfennig, Andrea; Pisanu, Claudia; Potash, James B; Reif, Andreas; Reininghaus, Eva; Rietschel, Marce ...; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter ...; Schubert, Klaus ...; Schweizer, Barba ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul D; Shimoda, Katzuta ...; Simhandl, Christ ...; Slaney, Claire M; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Witt, Stephanie ...; Zandi, Peter P; Fullerton, Janic ...; Alda, Martin; Frye, Mark A; Schulze, Thomas ...; McMahon, Francis ...; Biernacka, Joann ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

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