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A genetically infor...
A genetically informed Registered Report on adverse childhood experiences and mental health
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- Baldwin, J. R. (author)
- Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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- Sallis, H. M. (author)
- MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; NIHR Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
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- Schoeler, T. (author)
- Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK
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- Taylor, M. J. (author)
- Karolinska Institutet
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- Kwong, A. S. F. (author)
- MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; Division of Psychiatry, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK
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- Tielbeek, J. J. (author)
- CNCR, Amsterdam Neuroscience Campus, VU University, Amsterdam, the Netherlands
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- Barkhuizen, W. (author)
- Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK
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- Warrier, V. (author)
- Department of Psychiatry, University of Cambridge, Cambridge, UK
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- Howe, L. D. (author)
- MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK
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- Danese, A. (author)
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National and Specialist CAMHS Trauma, Anxiety, and Depression Clinic, South London and Maudsley NHS Foundation Trust, London, UK
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- McCrory, E. (author)
- Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Anna Freud National Centre for Children and Families, London, UK
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- Rijsdijk, F. (author)
- Psychology Department, Faculty of Social Sciences, Anton de Kom University, Paramaribo, Suriname
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Lundström, Sebastian (author)
- Gothenburg University,Göteborgs universitet,Centrum för etik, juridik och mental hälsa,Gillbergcentrum,Centre for Ethics, Law, and Mental Health,Gillberg Neuropsychiatry Centre,Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Centre for Ethics, Law and Mental Health (CELAM), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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- Karlsson, R. (author)
- Karolinska Institutet
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- Lichtenstein, P. (author)
- Karolinska Institutet
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Munafo, M. (author)
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- Pingault, J. B. (author)
- Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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(creator_code:org_t)
- 2022-12-08
- 2023
- English.
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In: Nature Human Behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 7:2, s. 269-290
- Related links:
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Abstract
Subject headings
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- Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene-environment correlations and genetic confounding of the associations between ACEs and mental health. Regarding gene-environment correlations, children with higher polygenic scores for mental health problems had a small increase in odds of ACEs. Regarding genetic confounding, elevated risk of mental health problems in children exposed to ACEs was at least partially due to pre-existing genetic risk. However, some ACEs (such as childhood maltreatment and parental mental illness) remained associated with mental health problems independent of genetic confounding. These findings suggest that interventions addressing heritable psychiatric vulnerabilities in children exposed to ACEs may help reduce their risk of mental health problems.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- genotype-environment correlations
- genome-wide association
- affective-disorders
- behavioral-problems
- drug-abuse
- children
- risk
- maltreatment
- transmission
- psychopathology
- Psychology
- Science & Technology - Other Topics
- Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Baldwin, J. R.
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Sallis, H. M.
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Schoeler, T.
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Taylor, M. J.
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Kwong, A. S. F.
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Tielbeek, J. J.
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show more...
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Barkhuizen, W.
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Warrier, V.
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Howe, L. D.
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Danese, A.
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McCrory, E.
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Rijsdijk, F.
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Larsson, Henrik, ...
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Lundström, Sebas ...
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Karlsson, R.
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Lichtenstein, P.
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Munafo, M.
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Pingault, J. B.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Nature Human Beh ...
- By the university
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University of Gothenburg
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Örebro University
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Karolinska Institutet