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NSAID-exacerbated r...
NSAID-exacerbated respiratory disease: a population study.
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- Andersén, Heidi (author)
- Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland; Thoracic Oncology Unit, Karolinska University Hospital, Tema Cancer, Stockholm, Sweden; Oncology Unit, Vaasa Keskussairaala, Vaasa, Finland
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- Ilmarinen, Pinja (author)
- Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland; Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland
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- Honkamäki, Jasmin (author)
- Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland
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- Tuomisto, Leena E (author)
- Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland
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- Hisinger-Mölkänen, Hanna (author)
- Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Backman, Helena (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Lundbäck, Bo, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Dept of Internal Medicine, Krefting Research Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Rönmark, Eva (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Haahtela, Tari (author)
- Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Sovijärvi, Anssi (author)
- Faculty of Medicine, University of Helsinki, Helsinki, Finland; Unit of Clinical Physiology, Dept of Clinical Physiology and Nuclear Medicine, HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
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- Lehtimäki, Lauri (author)
- Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland; Allergy Centre, Tampere University Hospital, Tampere, Finland
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- Piirilä, Päivi (author)
- Faculty of Medicine, University of Helsinki, Helsinki, Finland; Unit of Clinical Physiology, Dept of Clinical Physiology and Nuclear Medicine, HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
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- Kankaanranta, Hannu, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Krefting Research Centre,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland; Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; Dept of Internal Medicine, Krefting Research Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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(creator_code:org_t)
- 2022-01-13
- 2022
- English.
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In: ERJ open research. - : European Respiratory Society (ERS). - 2312-0541. ; 8:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Nonsteroidal anti-inflammatory drugs (NSAIDs) may exacerbate respiratory symptoms. A recent European Academy of Allergy and Clinical Immunology position paper recommended the use of an acronym, N-ERD (NSAID-exacerbated respiratory disease), for this hypersensitivity associated with asthma or chronic rhinosinusitis with or without nasal polyposis. Our aim was to estimate the prevalence of N-ERD and identify factors associated with N-ERD.In 2016, a cross-sectional questionnaire survey of a random adult population of 16000 subjects aged 20-69years was performed in Helsinki and Western Finland. The response rate was 51.5%.The prevalence was 1.4% for N-ERD, and 0.7% for aspirin-exacerbated respiratory disease (AERD). The prevalence of N-ERD was 6.9% among subjects with asthma and 2.7% among subjects with rhinitis. The risk factors for N-ERD were older age, family history of asthma or allergic rhinitis, long-term smoking and exposure to environmental pollutants. Asthmatic subjects with N-ERD had a higher risk of respiratory symptoms, severe hypersensitivity reactions and hospitalisations than asthmatic subjects without N-ERD. The subphenotype of N-ERD with asthma was most symptomatic. Subjects with rhinitis associated with N-ERD, which would not be included in AERD, had the fewest symptoms.We conclude that the prevalence of N-ERD was 1.4% in a representative Finnish adult population sample. Older age, family history of asthma or allergic rhinitis, cumulative exposure to tobacco smoke, secondhand smoke, and occupational exposures increased odds of N-ERD. N-ERD was associated with significant morbidity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andersén, Heidi
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Ilmarinen, Pinja
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Honkamäki, Jasmi ...
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Tuomisto, Leena ...
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Hisinger-Mölkäne ...
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Backman, Helena
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Lundbäck, Bo, 19 ...
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Rönmark, Eva
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Haahtela, Tari
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Sovijärvi, Anssi
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Lehtimäki, Lauri
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Piirilä, Päivi
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Kankaanranta, Ha ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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ERJ open researc ...
- By the university
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University of Gothenburg
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Umeå University