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Development and Val...
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Sjöström, MartinLund University,Lunds universitet,Bröstcancer Proteogenomik,Forskargrupper vid Lunds universitet,Individuell Bröstcancerbehandling,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast cancer Proteogenomics,Lund University Research Groups,Personalized Breast Cancer Treatment,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, San Francisco
(författare)
Development and Validation of a Genomic Profile for the Omission of Local Adjuvant Radiation in Breast Cancer.
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/323878
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https://gup.ub.gu.se/publication/323878URI
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https://doi.org/10.1200/JCO.22.00655DOI
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https://lup.lub.lu.se/record/e9f9e53f-69dc-4cd1-bbce-7a8e47498b47URI
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Adjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.We analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-conserving surgery: SweBCG91-RT (stage I-II, no adjuvant systemic therapy) and Princess Margaret (age 50 years or older, T1-T2, adjuvant tamoxifen). Transcriptome-wide profiling was performed (Affymetrix Human Exon 1.0 ST microarray). Patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors and with gene expression data were included. The SweBCG91-RT cohort was divided into training (N = 243) and validation (N = 354) cohorts. A 16-gene signature named Profile for the Omission of Local Adjuvant Radiation (POLAR) was trained to predict locoregional recurrence (LRR) using elastic net regression. POLAR was then validated in the SweBCG91-RT validation cohort and the Princess Margaret cohort (N = 132).Patients categorized as POLAR low-risk without RT had a 10-year LRR of 6% (95% CI, 2 to 16) and 7% (0 to 27) in SweBCG91-RT and Princess Margaret cohorts, respectively. There was no significant benefit from RT in POLAR low-risk patients (hazard ratio [HR], 1.1 [0.39 to 3.4], P = .81, and HR, 1.5 [0.14 to 16], P = .74, respectively). Patients categorized as POLAR high-risk had a significant decreased risk of LRR with RT (HR, 0.43 [0.24 to 0.78], P = .0055, and HR, 0.25 [0.07 to 0.92], P = .038, respectively). An exploratory analysis testing for interaction between RT and POLAR in the combined validation cohort was performed (P = .066).The novel POLAR genomic signature on the basis of LRR biology may identify patients with a low risk of LRR despite not receiving RT, and thus may be candidates for RT omission.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fyles, AnthonyUniversity of Toronto
(författare)
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Liu, Fei-FeiUniversity of Toronto
(författare)
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McCready, DavidUniversity of Toronto
(författare)
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Shi, WeiUniversity of Toronto
(författare)
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Rey-McIntyre, KatrinaUniversity of Toronto
(författare)
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Chang, S Laura
(författare)
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Feng, Felix YUniversity of California, San Francisco
(författare)
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Speers, Corey WUniversity of Michigan Health System
(författare)
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Pierce, Lori JUniversity of Michigan Health System
(författare)
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Holmberg, Erik,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrenska Academy(Swepub:gu)xholer
(författare)
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Fernö, MårtenLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Breast Cancer Treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-mfe
(författare)
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Malmström, PerLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)onk-pma
(författare)
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Karlsson, Per,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrenska Academy(Swepub:gu)xkperd
(författare)
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Bröstcancer ProteogenomikForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology41:8, s. 1533-15401527-7755
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Ingår i:Journal of Clinical Oncology41:8, s. 1533-15400732-183X
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Till lärosätets databas
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Sjöström, Martin
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Fyles, Anthony
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Liu, Fei-Fei
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McCready, David
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Shi, Wei
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Rey-McIntyre, Ka ...
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visa fler...
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Chang, S Laura
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Feng, Felix Y
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Speers, Corey W
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Pierce, Lori J
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Holmberg, Erik, ...
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Fernö, Mårten
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Malmström, Per
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Karlsson, Per, 1 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Journal of clini ...
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Journal of Clini ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet