Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine

Svedmyr, Sven,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine (författare)

We recruited 5,970 patients with hypertension with obstructive sleep apnea (OSA) on current antihypertensive treatment from the European Sleep Apnea Database (ESADA) cohort. The group was subdivided into those receiving monotherapy (n = 3,594) and those receiving dual combined therapy (n = 2,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta-blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta-blocker was associated with lower systolic blood pressure, particularly in non-obese middle-aged males with hypertension. Conversely, the combination of a beta-blocker and a diuretic was associated with lower systolic and diastolic blood pressure in patients with hypertension with moderate-severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross-sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in patients with hypertension with OSA. Controlled trials are warranted.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
antihypertensive treatment
beta-blocker
blood pressure control
diuretic
hypertension
obstructive sleep apnea
heart-failure
Neurosciences & Neurology

Hedner, Jan A,1953Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xhedja (författare)
Bonsignore, M. R. (författare)
Lombardi, C. (författare)
Parati, G. (författare)
Ludka, O. (författare)
Zou, Ding,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xzoudi (författare)
Grote, Ludger,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xgrolu (författare)
Göteborgs universitetInstitutionen för medicin (creator_code:org_t)

Av författaren/redakt...: Svedmyr, Sven, 1 ...; Hedner, Jan A, 1 ...; Bonsignore, M. R ...; Lombardi, C.; Parati, G.; Ludka, O.; visa fler...; Zou, Ding, 1970; Grote, Ludger, 1 ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.