Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer

• Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

NOX

reactive oxygen species

PI3K pathway

cancer

class-ia pi3k

nadph oxidase

respiratory burst

dependent activation

cell-proliferation

pathway

phosphorylation

p47(phox)

metastasis

inhibitor

Biochemistry & Molecular Biology

Pharmacology & Pharmacy

Food Science

& Technology

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ref (ämneskategori)

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