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Assessing the commu...
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Andreasson, Ulf,1968Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
Assessing the commutability of candidate reference materials for the harmonization of neurofilament light measurements in blood
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-01-31
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Walter de Gruyter GmbH,2023
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/324333
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https://gup.ub.gu.se/publication/324333URI
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https://doi.org/10.1515/cclm-2022-1181DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objectives Neurofilament light chain (NfL) concentration in blood is a biomarker of neuro-axonal injury in the nervous system and there now exist several assays with high enough sensitivity to measure NfL in serum and plasma. There is a need for harmonization with the goal of creating a certified reference material (CRM) for NfL and an early step in such an effort is to determine the best matrix for the CRM. This is done in a commutability study and here the results of the first one for NfL in blood is presented.Methods Forty paired individual serum and plasma samples were analyzed for NfL on four different analytical platforms. Neat and differently spiked serum and plasma were evaluated for their suitability as a CRM using the difference in bias approach.Results The correlation between the different platforms with regards to measured NfL concentrations were very high (Spearman's rho >= 0.96). Samples spiked with cerebrospinal fluid (CSF) showed higher commutability compared to samples spiked with recombinant human NfL protein and serum seems to be a better choice than plasma as the matrix for a CRM.Conclusions The results from this first commutability study on NfL in serum/plasma showed that it is feasible to create a CRM for NfL in blood and that spiking should be done using CSF rather than with recombinant human NfL protein.
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Gobom, JohanGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xgobjo
(author)
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Delatour, V.
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Auclair, G.
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Noam, Y.
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Lee, S. P.
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Wen, J. S.
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Jeromin, A.
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Arslan, Burak,1990Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xarsbu
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Maceski, A.
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Willemse, E.
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
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Kuhle, J.
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Clinical Chemistry and Laboratory Medicine: Walter de Gruyter GmbH61:7, s. 1245-12541434-66211437-4331
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Andreasson, Ulf, ...
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Gobom, Johan
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Delatour, V.
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Auclair, G.
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Noam, Y.
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Lee, S. P.
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Wen, J. S.
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Jeromin, A.
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Arslan, Burak, 1 ...
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Maceski, A.
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Willemse, E.
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Zetterberg, Henr ...
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Kuhle, J.
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Blennow, Kaj, 19 ...
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University of Gothenburg