Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts

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Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts

Westbury, L. D. (författare): Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.,Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.,University of Southampton,University of Liège

Beaudart, C. (författare): Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.,University of Liège

Bruyere, O. (författare): Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.,University of Liège

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Cauley, J. A. (författare): Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.,University of Pittsburgh

Cawthon, P. (författare): Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.,University of California, San Francisco,California Pacific Medical Center

Cruz-Jentoft, A. J. (författare): Hosp Univ Ramon y Cajal IRYCIS, Serv Geriatr, Madrid, Spain.,Hospital Ramón Y Cajal

Curtis, E. M. (författare): Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Sheffield, Ctr Integrated Res Musculoskeletal Ageing CIMA, Mellanby Ctr Bone Res, Sheffield, S Yorkshire, England.,University of Southampton,Australian Catholic University,University of Sheffield

Ensrud, K. (författare): Univ Minnesota, Med & Epidemiol & Community Hlth, Minneapolis, MN USA.;Minneapolis VA Hlth Care Syst, Ctr Care Delivery & Outcomes Res, Minneapolis, MN USA.,University of Minnesota

Fielding, R. A. (författare): Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.,Jean Mayer USDA Human Nutrition Research Center on Aging

Johansson, Helena, 1981 (författare): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Gothenburg, Sahlgrenska Osteoporosis Ctr, Inst Med, Gothenburg, Sweden.,Australian Catholic University

Kanis, J. A. (författare): Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England.,Australian Catholic University,University of Sheffield

Karlsson, Magnus K. (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital

Lane, N. E. (författare): UC Davis Hlth, Div Rheumatol, Dept Internal Med, Sacramento, CA USA.

Lengele, L. (författare)

Lorentzon, M. (författare): Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Sahlgrens Acad, Sahlgrenska Univ Hosp, Inst Med, Geriatr Med, Mölndal, Sweden.,Australian Catholic University,Sahlgrenska University Hospital

McCloskey, E. (författare): Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.;Victoria Univ Wellington, Wellington, New Zealand.,University of Southampton,Te Herenga Waka / Victoria University of Wellington

Mellström, Dan, 1945 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res CBAR, Gothenburg, Sweden.,Sahlgrenska Academy

Newman, A. B. (författare): Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.,University of Pittsburgh

Ohlsson, Claes, 1965 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Osteoporosis Ctr, Dept Internal Med & Clin Nutr,Inst Med,Ctr Bone &, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, Gothenburg, Sweden.,Sahlgrenska Academy,Sahlgrenska University Hospital

Orwoll, E. (författare): Oregon Hlth & Sci Univ, Portland, OR 97201 USA.,Oregon Health & Science University

Reginster, J. Y. (författare): Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.,University of Liège

Ribom, Eva (författare): Uppsala University,Uppsala universitet,Ortopedi

Rosengren, Björn E. (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital

Schousboe, J. T. (författare): Pk Nicollet Clin, Bloomington, MN USA.;HealthPartners Inst, Bloomington, MN USA.;Univ Minnesota, Minneapolis, MN USA.,University of Minnesota

Shiroma, E. J. (författare): NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, Baltimore, MD 21224 USA.,National Institute on Aging, United States

Harvey, N. C. (författare): Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.;Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England.,University of Southampton,University of Oxford

Dennison, E. M. (författare)

Cooper, C. (författare)

Int Musculoskeletal Ageing, Network (författare)

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Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium. (creator_code:org_t)

2023-01-05
2023
Engelska.
Ingår i: Journal of Cachexia Sarcopenia and Muscle. - : Wiley. - 2190-5991 .- 2190-6009. ; 14:1, s. 565-575

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BackgroundThe 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health-related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes. MethodsWhite men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4-6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m(2)), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random-effects meta-analysis. ResultsMean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow-up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (kappa = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I-2: 0.0%]; SDOC [2.75 (2.28, 3.31), I-2: 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I-2: 58.3%]. ConclusionsThere was low prevalence and poor agreement among recent sarcopenia definitions in community-dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

Epidemiology
Sarcopenia
Ageing
Mortality
Prevalence
quality-of-life
gait speed
older
epidemiology
determinants
performance
fractures
mros
Geriatrics & Gerontology
General & Internal Medicine
Epidemiology

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