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Genetic mechanisms of 184 neuro-related proteins in human plasma.

Repetto, Linda (author)
Chen, Jiantao (author)
Yang, Zhijian (author)
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Zhai, Ranran (author)
Timmers, Paul R H J (author)
Li, Ting (author)
Twait, Emma L (author)
May-Wilson, Sebastian (author)
Muckian, Marisa D (author)
Prins, Bram P (author)
Png, Grace (author)
Kooperberg, Charles (author)
Johansson, Åsa (author)
Hillary, Robert F (author)
Wheeler, Eleanor (author)
Pan, Lu (author)
Karolinska Institutet
He, Yazhou (author)
Klasson, Sofia (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Ahmad, Shahzad (author)
Peters, James E (author)
Gilly, Arthur (author)
Karaleftheri, Maria (author)
Tsafantakis, Emmanouil (author)
Haessler, Jeffrey (author)
Gyllensten, Ulf (author)
Harris, Sarah E (author)
Wareham, Nicholas J (author)
Göteson, Andreas (author)
Lagging, Cecilia (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Ikram, Mohammad Arfan (author)
van Duijn, Cornelia M (author)
Jern, Christina, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Landén, Mikael, 1966 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Extern,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,External,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Langenberg, Claudia (author)
Deary, Ian J (author)
Marioni, Riccardo E (author)
Enroth, Stefan (author)
Reiner, Alexander P (author)
Dedoussis, George (author)
Zeggini, Eleftheria (author)
Butterworth, Adam S (author)
Mälarstig, Anders (author)
Wilson, James F (author)
Navarro, Pau (author)
Shen, Xia (author)
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 (creator_code:org_t)
Cold Spring Harbor Laboratory, 2023
2023
English.
In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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  • Journal article (other academic/artistic)
Abstract Subject headings
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  • Understanding the genetic basis of neuro-related proteins is essential for dissecting the disease etiology of neuropsychiatric disorders and other complex traits and diseases. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits as well as complex diseases such as hypertension, high cholesterol, immune-related disorders, and psychiatric disorders. Integrating with established drug information, we validated 13 combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets for diseases and comorbidities. This consortium effort provides a large-scale proteogenomic resource for biomedical research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Publication and Content Type

vet (subject category)
art (subject category)

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