SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Rolfs Arndt)
 

Search: WFRF:(Rolfs Arndt) > (2020-2023) > Radiomics-Derived B...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Bretzner, MartinUniversity of Lille,Massachusetts General Hospital,Harvard Medical School (author)

Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/324801
  • https://gup.ub.gu.se/publication/324801URI
  • https://doi.org/10.1212/WNL.0000000000201596DOI
  • https://lup.lub.lu.se/record/eb6aa270-e523-4ae8-ad6a-57f93dd810c2URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • While chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age." We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors and worse functional outcomes.We extracted radiomics from T2-FLAIR images acquired during acute stroke clinical evaluation. Brain age was determined from brain parenchyma radiomics using an ElasticNet linear regression model. Subsequently, relative brain age (RBA), which expresses brain age in comparison with chronological age-matched peers, was estimated. Finally, we built a linear regression model of RBA using clinical cardiovascular characteristics as inputs and a logistic regression model of favorable functional outcomes taking RBA as input.We reviewed 4,163 patients from a large multisite ischemic stroke cohort (mean age = 62.8 years, 42.0% female patients). T2-FLAIR radiomics predicted chronological ages (mean absolute error = 6.9 years, r = 0.81). After adjustment for covariates, RBA was higher and therefore described older-appearing brains in patients with hypertension, diabetes mellitus, a history of smoking, and a history of a prior stroke. In multivariate analyses, age, RBA, NIHSS, and a history of prior stroke were all significantly associated with functional outcome (respective adjusted odds ratios: 0.58, 0.76, 0.48, 0.55; all p-values < 0.001). Moreover, the negative effect of RBA on outcome was especially pronounced in minor strokes.T2-FLAIR radiomics can be used to predict brain age and derive RBA. Older-appearing brains, characterized by a higher RBA, reflect cardiovascular risk factor accumulation and are linked to worse outcomes after stroke.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bonkhoff, Anna K (author)
  • Schirmer, Markus D (author)
  • Hong, Sungmin (author)
  • Dalca, Adrian (author)
  • Donahue, Kathleen (author)
  • Giese, Anne-Katrin (author)
  • Etherton, Mark R (author)
  • Rist, Pamela M (author)
  • Nardin, Marco (author)
  • Regenhardt, Robert W (author)
  • Leclerc, Xavier (author)
  • Lopes, Renaud (author)
  • Gautherot, Morgan (author)
  • Wang, Clinton (author)
  • Benavente, Oscar R (author)
  • Wasselius, JohanLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups(Swepub:lu)oft-jws (author)
  • Donatti, Amanda (author)
  • Griessenauer, Christoph (author)
  • Heitsch, Laura (author)
  • Holmegaard, Margareta,1942Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xholmm (author)
  • Jood, Katarina,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjooka (author)
  • Jimenez-Conde, Jordi (author)
  • Kittner, Steven J (author)
  • Lemmens, Robin (author)
  • Levi, Christopher R (author)
  • McArdle, Patrick F (author)
  • McDonough, Caitrin W (author)
  • Meschia, James F (author)
  • Phuah, Chia-Ling (author)
  • Rolfs, Arndt (author)
  • Ropele, Stefan (author)
  • Rosand, Jonathan (author)
  • Roquer, Jaume (author)
  • Rundek, Tatjana (author)
  • Sacco, Ralph L (author)
  • Schmidt, Reinhold (author)
  • Sharma, Pankaj (author)
  • Slowik, Agnieszka (author)
  • Sousa, Alessandro (author)
  • Stanne, Tara M,1979Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xmcdta (author)
  • Strbian, Daniel (author)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (author)
  • Thijs, Vincent (author)
  • Vagal, Achala (author)
  • Wasselius, Johan (author)
  • Woo, Daniel (author)
  • Wu, Ona (author)
  • Zand, Ramin (author)
  • Worrall, Bradford B (author)
  • Maguire, Jane (author)
  • Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)neur-ali (author)
  • Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjerch (author)
  • Golland, Polina (author)
  • Kuchcinski, Grégory (author)
  • Rost, Natalia SMassachusetts General Hospital,Harvard Medical School (author)
  • University of LilleMassachusetts General Hospital (creator_code:org_t)
  • International Stroke Genetics Consortium

Related titles

  • In:Neurology100:81526-632X0028-3878

Internet link

Find in a library

  • Neurology (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view