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The relevance of ri...
The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
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- Bonkhoff, Anna K (author)
- Harvard Medical School
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Schirmer, Markus D (author)
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Bretzner, Martin (author)
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Hong, Sungmin (author)
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Regenhardt, Robert W (author)
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Donahue, Kathleen L (author)
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Nardin, Marco J (author)
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Dalca, Adrian V (author)
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Giese, Anne-Katrin (author)
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Etherton, Mark R (author)
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Hancock, Brandon L (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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McIntosh, Elissa C (author)
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Attia, John (author)
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- Wasselius, J. (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital
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Donatti, Amanda (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Heitsch, Laura (author)
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- Holmegaard, Lukas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Jimenez-Conde, Jordi (author)
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Kittner, Steven J (author)
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Lemmens, Robin (author)
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Levi, Christopher R (author)
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McDonough, Caitrin W (author)
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Meschia, James F (author)
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Phuah, Chia-Ling (author)
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Ropele, Stefan (author)
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Rosand, Jonathan (author)
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Roquer, Jaume (author)
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Rundek, Tatjana (author)
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Sacco, Ralph L (author)
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Schmidt, Reinhold (author)
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Sharma, Pankaj (author)
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Slowik, Agnieszka (author)
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Sousa, Alessandro (author)
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- Stanne, Tara M, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Strbian, Daniel (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Thijs, Vincent (author)
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Vagal, Achala (author)
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Wasselius, Johan (author)
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Woo, Daniel (author)
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Zand, Ramin (author)
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McArdle, Patrick F (author)
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Worrall, Bradford B (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Lindgren, Arne G. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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Maguire, Jane (author)
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Wu, Ona (author)
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- Rost, Natalia S (author)
- Harvard Medical School
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(creator_code:org_t)
- 2022-11-28
- 2023
- English.
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In: Human brain mapping. - : Wiley. - 1097-0193 .- 1065-9471. ; 44:4, s. 1579-1592
- Related links:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolled in the multisite MRI-GENIE study. Spatially normalized structural stroke lesions were parcellated into 108 atlas-defined bilateral (sub)cortical brain regions. Unfavorable outcome (mRS>2) was modeled in a Bayesian logistic regression framework. Effects of individual brain regions were captured as two compound effects for (i) six bilateral rich club and (ii) all further non-rich club regions. In spatial specificity analyses, we randomized the split into "rich club" and "non-rich club" regions and compared the effect of the actual rich club regions to the distribution of effects from 1000 combinations of six random regions. In sex-specific analyses, we introduced an additional hierarchical level in our model structure to compare male and female-specific rich club effects. A total of 822 patients (age: 64.7[15.0], 39% women) were analyzed. Rich club regions had substantial relevance in explaining unfavorable functional outcome (mean of posterior distribution: 0.08, area under the curve: 0.8). In particular, the rich club-combination had a higher relevance than 98.4% of random constellations. Rich club regions were substantially more important in explaining long-term outcome in women than in men. All in all, lesions in rich club regions were associated with increased odds of unfavorable outcome. These effects were spatially specific and more pronounced in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Female
- Humans
- Male
- Middle Aged
- Bayes Theorem
- Brain
- Ischemic Stroke
- diagnostic imaging
- pathology
- Models
- Neurological
- Stroke
- Bayesian hierarchical modeling
- functional outcome
- lesion-symptom mapping
- rich club
- sex differences
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bonkhoff, Anna K
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Schirmer, Markus ...
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Bretzner, Martin
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Hong, Sungmin
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Regenhardt, Robe ...
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Donahue, Kathlee ...
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show more...
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Nardin, Marco J
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Dalca, Adrian V
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Giese, Anne-Katr ...
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Etherton, Mark R
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Hancock, Brandon ...
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Tatlisumak, Turg ...
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McIntosh, Elissa ...
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Attia, John
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Wasselius, J.
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Donatti, Amanda
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Jern, Christina, ...
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Heitsch, Laura
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Holmegaard, Luka ...
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Jood, Katarina, ...
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Jimenez-Conde, J ...
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Kittner, Steven ...
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Lemmens, Robin
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Levi, Christophe ...
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McDonough, Caitr ...
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Meschia, James F
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Phuah, Chia-Ling
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Ropele, Stefan
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Rosand, Jonathan
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Roquer, Jaume
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Rundek, Tatjana
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Sacco, Ralph L
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Schmidt, Reinhol ...
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Sharma, Pankaj
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Slowik, Agnieszk ...
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Sousa, Alessandr ...
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Stanne, Tara M, ...
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Strbian, Daniel
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Thijs, Vincent
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Vagal, Achala
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Wasselius, Johan
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Woo, Daniel
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Zand, Ramin
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McArdle, Patrick ...
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Worrall, Bradfor ...
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Lindgren, Arne G ...
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Maguire, Jane
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Wu, Ona
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Rost, Natalia S
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Human brain mapp ...
- By the university
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University of Gothenburg
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Lund University