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Image-derived input...
Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction
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- Young, Peter N E (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, University of Gothenburg, Wallinsgatan 6, Mölndal, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Psychiat & Neurochem, Wallinsgatan 6, S-41341 Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
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- Appel, Lieuwe (författare)
- Uppsala universitet,Radiologi
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- Tolf, Andreas (författare)
- Uppsala universitet,Neurologi
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- Kosmidis, S. (författare)
- Uppsala universitet,Radiologi
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- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Neurologi
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- Rieckmann, Anna (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,Munich Center for the Economic of Aging, Max Planck Institute for Social Law and Social Policy, Munich, Germany,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.;Max Planck Inst Social Law & Social Policy, Munich Ctr Econ Aging, Munich, Germany.
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- Schöll, Michael, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, University of Gothenburg, Wallinsgatan 6, Mölndal, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom,Univ Gothenburg, Dept Psychiat & Neurochem, Wallinsgatan 6, S-41341 Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.;UCL, Queen Sq Inst Neurol, Dementia Res Ctr, London, England.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2023-03-07
- 2023
- Engelska.
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Ingår i: EJNMMI Physics. - : Springer Science and Business Media LLC. - 2197-7364. ; 10:1
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundQuantitative positron emission tomography (PET) scans of the brain typically require arterial blood sampling but this is complicated and logistically challenging. One solution to remove the need for arterial blood sampling is the use of image-derived input functions (IDIFs). Obtaining accurate IDIFs, however, has proved to be challenging, mainly due to the limited resolution of PET. Here, we employ penalised reconstruction alongside iterative thresholding methods and simple partial volume correction methods to produce IDIFs from a single PET scan, and subsequently, compare these to blood-sampled input curves (BSIFs) as ground truth. Retrospectively we used data from sixteen subjects with two dynamic O-15-labelled water PET scans and continuous arterial blood sampling: one baseline scan and another post-administration of acetazolamide.ResultsIDIFs and BSIFs agreed well in terms of the area under the curve of input curves when comparing peaks, tails and peak-to-tail ratios with R-2 values of 0.95, 0.70 and 0.76, respectively. Grey matter cerebral blood flow (CBF) values showed good agreement with an average difference between the BSIF and IDIF CBF values of 2% +/- and a coefficient of variation (CoV) of 7.3%.ConclusionOur results show promising results that a robust IDIF can be produced for dynamic O-15-water PET scans using only the dynamic PET scan images with no need for a corresponding MRI or complex analytical techniques and thereby making routine clinical use of quantitative CBF measurements with O-15-water feasible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- O-15-water PET
- Cerebral blood flow
- Image-derived input function
- Partial volume correction
- PET
- 15O–water PET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Young, Peter N E
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Appel, Lieuwe
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Tolf, Andreas
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Kosmidis, S.
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Burman, Joachim, ...
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Rieckmann, Anna
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visa fler...
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Schöll, Michael, ...
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Lubberink, Mark
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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EJNMMI Physics
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet