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  • Eberhard, AnnaLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Helsingborg Hospital (författare)

Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain-a 5-year follow-up study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-02-27
  • Springer Science and Business Media LLC,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/325012
  • https://gup.ub.gu.se/publication/325012URI
  • https://doi.org/10.1186/s13075-023-03015-9DOI
  • https://lup.lub.lu.se/record/450aca49-463b-44b5-b1cd-83d767398a3dURI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • ObjectivesTo evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early rheumatoid arthritis (RA).MethodsAn inception cohort of 233 patients with early RA, recruited in 1995-2005, was followed for 5 years. Disability was assessed with the Health Assessment Questionnaire (HAQ), and pain with a visual analogue scale (VAS; 0-100 mm). Radiographs of hands and feet were evaluated using the Sharp-van der Heijde score (SHS), including JSNS and ES. The relation for radiographic scores and other clinical parameters with pain and HAQ were evaluated cross-sectionally by multivariate linear regression analysis and over time using generalized estimating equations.ResultsES was significantly associated with HAQ cross-sectionally at inclusion, after 2 and after 5 years, and over time. Associations for HAQ with SHS and JSNS were weaker and less consistent compared with those for ES. There was no association between radiographic scores and pain at any visit. Both HAQ and pain were associated with parameters of disease activity. The strongest cross-sectional associations were found for the number of tender joints (adjusted p<0.001 at all visits).ConclusionJoint damage was associated with disability already in early RA. Erosions of hands and feet appear to have a greater influence on disability compared with joint space narrowing early in the disease. Pain was associated with other factors than joint destruction in early RA, in particular joint tenderness-suggesting an impact of pain sensitization.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rydell, EmilLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups(Swepub:lu)em5271ry (författare)
  • Forslind, KristinaLund University,Lunds universitet,Spenshults artrit grupp,Forskargrupper vid Lunds universitet,Spenshults arthritis group,Lund University Research Groups,Spenshult Research and Development Center(Swepub:lu)med-kfi (författare)
  • Bergman, StefanUniversity of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Spenshults artrit grupp,Forskargrupper vid Lunds universitet,Spenshults arthritis group,Lund University Research Groups,Spenshult Research and Development Center(Swepub:lu)med-seb (författare)
  • Mandl, ThomasLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups(Swepub:lu)medf-tma (författare)
  • Olofsson, TorLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)efor-tol (författare)
  • Jacobsson, Lennart T. H.,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:lu)orto-lja (författare)
  • Turesson, CarlLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ctn (författare)
  • ReumatologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Arthritis Research & Therapy: Springer Science and Business Media LLC25:11478-63541478-6362

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